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Transfusion Strategies for Acute Upper Gastrointestinal Bleeding Trial (2013)

In 2013, Dr. Villanueva et al. randomly assigned over 921 patients with upper gastrointestinal bleed who presented with either hematemesis or melena to either low transfusion goal of >7 threshold or greater transfusion goal of >9 threshold. Their goal was to assess all-cause mortality in these patients. Patients who received restrictive transfusion showed an almost double..

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RE-DUAL PCI Trial (2017): Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation

RE-DUAL PCI Trial Summary RE-DUAL PCI trial was a multi-center, randomized trial that compared the outcomes of triple and dual therapy as well as warfarin and dabigatran. Patients with AF who have undergone PCI (N=2,725) were randomly assigned to either triple therapy (aspirin, warfarin and a P2Y12 inhibitor) or dual therapy (dabigatran 150mg BD or 110mg..

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WOEST Trial (2013): Clopidogrel with or without aspirin in patients taking OAC and undergoing PCI

WOEST Trial Summary WOEST trial was an open-label randomized controlled trial in patients who were on oral anticoagulants and underwent PCI with coronary stenting. Patients who were on oral anticoagulants and underwent PCI with coronary artery stenting (N=573) were randomly assigned to 2 groups: Dual therapy (Clopidogrel and OAC) or triple therapy (Aspirin, clopidogrel, and..

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