Acute Coronary Syndrome CAST I 1991, Antiarrhythmics post-MI
ESSENCE 1997, Enoxaparin vs Unfractionated Heparin for UA/NSTEMI
CURE 2001, Effects of Clopidogrel plus Aspirin in Patients with NSTEMI
EPHESUS 2003, Eplerenone in patients with LV dysfunction after MI
COMMIT 2005, Metoprolol after acute MI
ACT 2011, Acetylcysteine in Coronary Angiography
ATLAS ACS-2 2012, Rivaroxaban in Acute Coronary Syndrome
CHAMPION PHOENIX 2013, Cangrelor vs Clopidogrel in PCI
CULPRIT-SHOCK 2018, Culprit lesion vs multivessel PCI in ACS with cardiogenic shock
SCOT-HEART 2018, CTA vs standard care in preventing MI
Anemia CHOIR 2006, Erythropoetin for anemia in non-dialysis CKD
Aortic Stenosis PARTNER A 2011, Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients
Arthritis BeSt 2005, DMARD with prednisone or infliximab in RA
EXTRA 2011, Omalizumab in Severe Allergic Asthma
METEOR 2013, Surgery vs Physical Therapy for a Meniscal Tear and Osteoarthritis
LESS 2014, Epidural Glucocorticoid Injections for Spinal Stenosis
ARDS PROSEVA 2013, Prone Positioning in Severe Acute Respiratory Distress Syndrome (ARDS)
ART 2017, Lung Recruitment and Titrated PEEP vs Low PEEP in ARDS
Atrial Fibrillation AFFIRM 2002, Rate control vs Rhythm control in Atrial Fibrillation
PROTECT-AF 2009, Percutaneous Closure of LAA in atrial fibrillation
RACE II 2010, Strict vs Lenient Control of Heart Rate in Atrial Fibrillation
ROCKET AF 2011, Rivaroxaban vs. warfarin in atrial fibrillation
ARISTOTLE 2011, Apixaban vs. warfarin in atrial fibrillation
ORBIT-AF 2013, Aspirin and OAC in Atrial Fibrillation
CABANA 2018, Catheter Ablation for Atrial Fibrillation
CASTLE-AF 2018, Catheter Ablation for Atrial Fibrillation with Heart Failure
Cardiac Arrest HACA 2002, Hypothermia in Cardiac Arrest
TTM 2014, 33 vs. 36°C body temperature after cardiac arrest
PARAMEDIC2 2018, Epinephrine in Out-of-Hospital Cardiac Arrest
Coronary Artery Disease LIPID 1998, Pravastatin in patients with coronary heart disease
HOPE 2000, ACE inhibitors, ramipril in high cardiovascular risk patients
CHARISMA 2006, Aspirin + clopidogrel vs. aspirin for CVD prevention
COURAGE 2007, PCI for stable CAD
JUPITER 2008, Rosuvastatin for prevention of CV events
POISE 2008, Metoprolol succinate in patients undergoing surgery
SYNTAX 2009, PCI vs CABG in severe CAD
FREEDOM 2012, Percutaneous Coronary Intervention (PCI) vs CABG in Patients with Diabetes and multivessel CAD
DAPT 2014, 12 or 30 months of dual antiplatelet therapy after drug-eluting stents PCI
EXCEL 2016, Everolimus-Eluting Stents or Bypass Surgery for Left Main CAD
COMPASS 2017, Rivaroxaban with or without ASA in stable CAD
MANAGE 2018, Dabigatran in myocardial injury after non-cardiac surgery
VITAL (Vitamin D) 2018, Vitamin D3 for prevention of CVD and cancer
VITAL (N3) 2018, N3 fatty acid supplements for prevention of CVD and cancer
REDUCE-IT 2018, Cardiovascular risk reduction with Icosapent ethyl for hypertriglyceridemia
ASPREE 2018, Aspirin for Primary Prevention in Healthy Adults
ARRIVE 2018, Aspirin for Primary Prevention in Adults at Moderate Cardiovascular Risk
COPD FLAME 2016, LABA + LAMA vs LABA + ICS for COPD
REDUCE 2013, Short term steroids in COPD exacerbation
Cirrhosis Albumin in SBP 1999, IV albumin in patients with cirrhosis and SBP
Rifaximin in HE 2013, Rifaxamin in hepatic encephalopathy
STOPAH 2015, Prednisolone in Alcoholic Hepatitis
Bezafibrate Trial 2018, Bezafibrate in Primary Biliary Cholangitis
Cancer Metachronous Gastric Trial 2018, H-Pylori treatment in Metachronous Gastric Cancer
Carotid artery stenosis CREST 2010, Stenting versus CEA in Carotid-Artery Stenosis
Depression SADHART 2002, Sertraline for depression after ACS
Diabetes Mellitus RABBIT2 2007, Basal-bolus insulin in inpatients with DM
EMPA-REG OUTCOMES 2015, Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes
CANVAS 2017, Canagliflozin in Type II DM
ASCEND ASA 2018, Aspirin for primary prevention of CVD in DM
ASCEND N3 2018, N3 fatty acid supplements for primary prevention in DM
Metformin in CKD Cohort 2018, Metformin in CKD
Closed Loop Insulin Trial 2018, Closed-loop Insulin Delivery in Non-ICU patients
Dialysis IDEAL 2010, Early versus Late Dialysis in Patients with ESRD
AKIKI 2016, Renal Replacement Therapy in ICU
Gastrointestinal Bleeding POP-UP 2016, Pantoprazole or Placebo for Stress Ulcer Prophylaxis
SUP-ICU 2018, Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU
Hypertension ALLHAT 2002, Antihypertensive drugs to prevent Heart Attack
SPYRAL HTN-ON MED 2018, Renal Denervation in Uncontrolled Hypertension
Barber Cluster Trial 2018, Barbershop Interventions in Controlling Blood Pressure
Ambulatory BP and Mortality 2018, Ambulatory BP measurements and mortality
Heart Failure DIG 1997, Digoxin in Heart failure with reduced ejection fraction
COMET 2003, Comparison of Carvedilol and Metoprolol in Chronic Heart Failure
Ancillary DIG 2006, Digoxin in Heart failure with preserved ejection fraction
DOSE 2011, Furosemide in Acute Decompensated Heart Failure
BLOCK HF 2013, Biventricular versus Right Ventricular Pacing in Heart Failure Patients with AV Block
TOPCAT 2014, Spironolactone in HFpEF
COAPT 2018, Mitral valve repair in Patients with Heart failure
PIONEER-HF 2018, Angiotensin-neprilysin inhibition in acute decompensated heart failure
Headache STRIVE 2017, Erenumab in Episodic Migraine
Infections PRORATA 2010, Procalcitonin guided antibiotic therapy in critically ill patients
Fidaxomicin in C. diff Infection 2011, Fidaxomicin versus vancomycin for Clostridium difficile infection
VALENCE 2014, Sofosbuvir and ribavirin in HCV
PROACT 2018, Procalcitonin in Lower Respiratory Tract Infections
POET 2018, IV vs PO Antibiotics in Infective Endocarditis
MERINO 2018, Piperacillin-Tazobactam vs Meropenem in Ceftriaxone resistant Infections
CAPSTONE-1 2018, Baloxavir Marboxil for Uncomplicated Influenza
Sepsis PROWESS-SHOCK 2012, Activated protein C (DrotAA) in Sepsis
TRISS 2014, Restrictive vs Liberal Transfusion in Septic Shock
ALBIOS 2014, Albumin in Severe Sepsis and Septic Shock
SALT-ED 2018, Balanced crystalloids versus saline in non-critically ill adults
ADRENAL 2018, Glucocorticoids in Septic Shock
APROCCHSS 2018, Hydrocortisone + Fludrocortisone in Septic Shock
BICAR-ICU 2018, Sodium Bicarbonate in Severe Metabolic Acidaemia
Stroke SPARCL 2006, High-dose atorvastatin after stroke or transient ischemic attack (TIA)
SOCRATES 2016, Ticagrelor versus aspirin in acute stroke or TIA
EXTEND-IA TNK 2018, Tenecteplase vs Alteplase in Ischemic Stroke
WAKE-UP 2018, MRI guided thrombolysis with alteplase in stroke with unknown time of onset
Screening AGE 2006, Mammographic screening from age 40 years
COLONPREV 2012, FIT vs. colonoscopy for colon cancer screening
NELSON 2018, CT scan for screening lung cancer
Smoking EAGLES 2018, Cardiovascular Safety of Smoking Cessation Medications
Thromboembolism WARFASA 2012, Aspirin for Recurrent VTE
EINSTEIN PE 2012, Rivaroxaban for Acute PE
AMPLIFY 2013, Apixaban for VTE
MOPETT 2013, Low-dose tPA for submassive PE
ADJUST PE 2014, Age Adjusted D Dimer for PE
ANNEXA 2015, Andexanet for reversal of Factor Xa Inhibitors
SOME 2015, Cancer screening in unprovoked VTE
AVERT 2018, Apixaban to Prevent Venous Thromboembolism in Patients with Cancer
Trauma PAMPer 2018, Prehospital Plasma in Trauma Patients