Cardiovascular Trials
Cardiovascular- REWIND Trial: Dulaglutide and cardiovascular outcomes in type 2 diabetes
- MET-REMODEL Trial: Metformin on LVH in patients with CAD without diabetes
- VADT Trial: Glucose Control and Vascular Complications in Veterans with Type 2 Diabetes
- CAPRICORN Trial: Effect of carvedilol on outcome after MI in patients with LV dysfunction
- ALIVE Trial: Amiodarone as Compared with Lidocaine for Shock-Resistant Ventricular Fibrillation
Critical Care Trials
Critical Care- CENSER Trial: Early Use of Norepinephrine in Septic Shock Resuscitation
- PreVent Trial (2019): Bag-Mask Ventilation during Tracheal Intubation of Critically Ill Adults
- HYPRESS Trial (2016): Effect of Hydrocortisone on Development of Shock Among Patients With Severe Sepsis
- SEPSISPAM Trial (2014): High versus low blood-pressure target in patients with septic shock
- TRICC Trial (1999): Transfusion requirements in critical care
Emergency Medicine Trials
Emergency Medicine- ALIVE Trial: Amiodarone as Compared with Lidocaine for Shock-Resistant Ventricular Fibrillation
- ARREST Trial: Amiodarone for Resuscitation after Out-of-Hospital Cardiac Arrest Due to Ventricular Fibrillation
- CRISTAL Trial (2013): Fluid Resuscitation with Colloids vs. Crystalloids in Hypovolemic Shock
- PARAMEDIC2 Trial: Epinephrine in Out-of-Hospital Cardiac Arrest
- PAMPer Trial: Prehospital Plasma in Trauma Patients
Endocrinology Trials
Endocrinology- REWIND Trial: Dulaglutide and cardiovascular outcomes in type 2 diabetes
- VADT Trial: Glucose Control and Vascular Complications in Veterans with Type 2 Diabetes
- CREDENCE Trial: Canagliflozin and renal outcomes in type II diabetes and nephropathy
- TABLET Trial (2019): Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception
- IDNT Trial (2001): Irbesartan in diabetic nephropathy
Gastroenterology Trials
Gastroenterology- Transfusion Strategies for Acute Upper Gastrointestinal Bleeding Trial (2013)
- COLONPREV: FIT vs. colonoscopy for colon cancer screening
- SUP-ICU: PPI prophylaxis in ICU patients at risk of GI bleed
- POP-UP: Pantoprazole or Placebo for Stress Ulcer Prophylaxis
- Albumin in Spontaneous Bacterial Peritonitis
Hematology Trials
Hematology- MSH Trial: Effect of Hydroxyurea on the Frequency of Painful Crises in Sickle Cell Anemia
- HERCULES Trial (2019): Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura
- TITAN Trial (2016): Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura
- TRAPS Trial (2018): Rivaroxaban vs. warfarin in antiphospholipid syndrome
- AVERT Trial: Apixaban to Prevent VTE in Patients with Cancer
Infectious Disease Trials
Infectious Disease- HYPRESS Trial (2016): Effect of Hydrocortisone on Development of Shock Among Patients With Severe Sepsis
- SEPSISPAM Trial (2014): High versus low blood-pressure target in patients with septic shock
- Project CLEAR Trial (2019): Decolonization to Reduce Postdischarge Infection Risk among MRSA Carriers
- PLACIDE Trial (2013): Lactobacilli and bifidobacteria in preventing antibiotic-associated and C.diff diarrhea
- OPTIC Trial (2019): Omadacycline for Community-Acquired Bacterial Pneumonia
Nephrology Trials
Nephrology- VA NEPHRON-D Trial: Combined Angiotensin Inhibition for the Treatment of Diabetic Nephropathy
- CREDENCE Trial: Canagliflozin and renal outcomes in type II diabetes and nephropathy
- PIVOTAL Trial (2019): Intravenous Iron in Patients Undergoing Maintenance Hemodialysis
- CARRESS-HF Trial (2012): Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome
- IDNT Trial (2001): Irbesartan in diabetic nephropathy
Neurology Trials
Neurology- RE-SPECT ESUS Trial: Dabigatran for Prevention of Recurrent Stroke after Cryptogenic Stroke
- LEAP trial (2019): Early vs Delayed Levodopa in Parkinson’s Disease
- CHANCE Trial (2013): Clopidogrel with aspirin in acute minor stroke or transient ischemic attack
- BRIDGE Trial (2015): Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation
- POINT Trial (2018): Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA
General Medicine Trials
General Medicine- NLST Trial: Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening
- OCTAVE Trial: Omapatrilat and enalapril in patients with hypertension
- PANSAID Trial (2019): Paracetamol and Ibuprofen on Morphine Consumption in the Total Hip Arthroplasty
- SPRINT MIND Trial (2019): Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia
- VITAL: N3 fatty acid supplements for prevention of CVD and cancer
Oncology Trials
Oncology- ATLAS Trial: 10 years vs. 5 years of tamoxifen in patients with breast cancer
- NLST Trial: Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening
- FREGAT Trial (2019): Minimally Invasive Esophagectomy for Esophageal Cancer
- PACIFIC Trial (2017): Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC
- AVERT Trial: Apixaban to Prevent VTE in Patients with Cancer
Pulmonology Trials
Pulmonology- ASCENT COPD Trial: Effect of Aclidinium Bromide on Major Cardiovascular Events and Exacerbations in High-Risk Patients With COPD
- PReVENT Trial (2018): Low vs Intermediate Tidal Volume Strategy in ICU Patients
- MOPETT: Low-dose tPA for submassive PE
- EINSTEIN PE: Rivaroxaban for Acute PE
- FLAME: LABA + LAMA vs LABA + ICS for COPD
Surgery Trials
Surgery- FIDELITY Trial: Arthroscopic Partial Meniscectomy versus Sham Surgery for a Degenerative Meniscal Tear
- POISE: Metoprolol succinate in patients undergoing non-cardiac surgery
- METEOR: Surgery vs Physical Therapy for a Meniscal Tear and Osteoarthritis
- STAMPEDE Trial: Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes
Rheumatology Trials
Rheumatology- RAVE Trial (2010): Rituximab versus cyclophosphamide for ANCA-associated vasculitis
- METEOR: Surgery vs Physical Therapy for a Meniscal Tear and Osteoarthritis
- BeSt trial: DMARD ± prednisone or infliximab in RA
- PRECISION Trial: Cardiovascular safety of celecoxib, naproxen, or ibuprofen for arthritis
