Topic
Year
Recent
Cardiology
Acute Coronary Syndrome (49)
ACT
2011, Acetylcysteine in Coronary Angiography
ATLAS ACS-2
2012, Rivaroxaban in Acute Coronary Syndrome
CADILLAC
2002, Angioplasty with Stenting, with or without Abciximab, in Acute Myocardial Infarction
CAPRICORN
2001, Effect of carvedilol on outcome after MI in patients with LV dysfunction
CAST I
1991, Antiarrhythmics post-MI
CHAMPION PHOENIX
2013, Cangrelor vs Clopidogrel in PCI
COMFORTABLE AMI
2012, Effect of Biolimus-Eluting Stents With Biodegradable Polymer vs Bare-Metal Stents on Cardiovascular Events Among Patients With STEMI
COMMIT
2005, Metoprolol after acute MI
COMPARE CRUSH
2020, Effect of Pre-Hospital Crushed Prasugrel Tablets in Patients with STEMI Planned for PCI
COMPARE-ACUTE
2017, Fractional Flow Reserve Guided-Multivessel Angioplasty in Myocardial Infarction
CONSENSUS II
1992, Effects of the Early Administration of Enalapril on Mortality in Patients with Acute MI
CULPRIT-SHOCK
2018, Culprit lesion vs multivessel PCI in ACS with cardiogenic shock
CURE
2001, Effects of Clopidogrel plus Aspirin in Patients with NSTEMI
CvLPRIT
2015. Complete versus lesion-only revascularization in patients undergoing primary PCI for STEMI and multivessel disease
DANAMI-3 PRIMULTI
2015, Complete revascularisation versus culprit lesion only PCI in STEMI and multivessel disease
EPHESUS
2003, Eplerenone in patients with LV dysfunction after MI
ESSENCE
1997, Enoxaparin vs Unfractionated Heparin for UA/NSTEMI
FAMOUS-NSTEMI
2014, Fractional flow reserve vs. angiography in guiding management to optimize outcomes in NSTEMI
FRISC II
2006, Invasive compared with non-invasive treatment in unstable coronary artery disease
IABP-SHOCK II
2012, Intraaortic Balloon Pump for Myocardial Infarction with Cardiogenic Shock
IMPROVE-IT
2015, Ezetimibe + statin in acute coronary syndrome (ACS)
ISAR-REACT 5
2019, Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes
MADIT-II
2002, Prophylactic Implantation of a Defibrillator in Patients with Myocardial Infarction and Reduced Ejection Fraction
MATRIX
2015, Bivalirudin or Unfractionated Heparin in Acute Coronary Syndromes
2015, Radial versus femoral access in patients with acute coronary syndromes
MIRACL
2001, Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes
OASIS-5
2006, Comparison of fondaparinux and enoxaparin in acute coronary syndromes
OAT
2006, Coronary Intervention for Persistent Occlusion after Myocardial Infarction
ODYSSEY OUTCOMES
2018, Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome
PEGASUS-TIMI 54
2015, Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarction
PLATO
2009, Ticagrelor versus clopidogrel in patients with acute coronary syndromes
PRAMI
2013, Randomized trial of preventative angioplasty in myocardial infarction
PROVE IT
2004, Intensive versus Moderate Lipid Lowering with Statins after Acute Coronary Syndromes
RAPID-TnT
2019, Rapid Assessment of Possible ACS in the Emergency Department With High-Sensitivity Troponin T
REALITY
2020, Transfusion Strategies in Patients With Myocardial Infarction and Anemia
RIVAL
2011, Radial versus femoral access for coronary angiography and intervention in patients with ACS
SADHART
2002, Sertraline for depression after ACS
SCOT-HEART
2018, CTA vs standard care in preventing MI
SHOCK
1999, Early Revascularization in Acute Myocardial Infarction Complicated by Cardiogenic Shock
SMART-DATE
2018, 6-month versus 12-month or longer DAPT after PCI in ACS
SYNERGY
2004, Enoxaparin vs unfractionated heparin in high-risk patients with UA/NSTEMI
TACTICS TIMI 18
2001, Early Invasive and Conservative Strategies in Patients with Unstable Coronary Syndromes Treated with Tirofiban
TIMACS
2009, Early versus Delayed Invasive Intervention in Acute Coronary Syndromes
TRANSIENT
2019, Timing of revascularization in patients with transient STEMI
TREAT
2019, Ticagrelor Versus Clopidogrel in Patients With STEMI Treated With Fibrinolysis
TRITON-TIMI 38
2007, Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndromes
TROPICAL-ACS
2017, Guided de-escalation of antiplatelet treatment in patients with ACS undergoing PCI
ULTIMATE
2018, 2018, IVUS vs angiography guided implantation of DES
VALIANT
2003, Valsartan vs. captopril in patients with acute MI and HF
VEST
2018, Wearable cardioverter-defibrillator after myocardial infarction
Amyloidosis (1)
ATTR-ACT
2018, Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy
Atrial Fibrillation (29)
AATAC
2016, Ablation vs. amiodarone for persistent atrial fibrillation in patients with CHF
ACTIVE A
2009, Effect of Clopidogrel Added to Aspirin in Patients with Atrial Fibrillation
ACTIVE W
2006, Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation
AF-CHF
2008, Rhythm Control versus Rate Control for Atrial Fibrillation and Heart Failure
AFFIRM
2002, Rate control vs Rhythm control in Atrial Fibrillation
AFIRE
2019, Antithrombotic Therapy for Atrial Fibrillation with Stable Coronary Disease
ALCOHOL-AF
2019, Impact of Alcohol Abstinence in Moderate Drinkers With Atrial Fibrillation
ARISTOTLE
2011, Apixaban vs. warfarin in atrial fibrillation
AUGUSTUS
2019, Antithrombotic Therapy or PCI in Atrial Fibrillation
AVERROES
2011, Apixaban in Patients with Atrial Fibrillation
Alcohol Abstinence
2020, Alcohol Abstinence in Drinkers with Atrial Fibrillation
BRIDGE
2015, Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation
CABANA
2018, Catheter Ablation for Atrial Fibrillation
CASTLE-AF
2018, Catheter Ablation for Atrial Fibrillation with Heart Failure
CRYSTAL AF
2014, Cryptogenic Stroke and Underlying Atrial Fibrillation
EARLY-AF
2021, Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation
EAST-AFNET 4
2020, Early Rhythm-Control Therapy in Patients with Atrial Fibrillation
ELDERCARE-AF
2020, Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
EMBRACE
2014, Atrial fibrillation in patients with cryptogenic stroke
ENGAGE AF-TIMI 48
2013, Edoxaban versus warfarin in patients with atrial fibrillation
FIRE AND ICE
2016, Cryoballoon or Radiofrequency Ablation for Paroxysmal Atrial Fibrillation
ORBIT-AF Registry
2013, Aspirin and OAC in Atrial Fibrillation
PRAGUE-17
2020, LAA Closure vs DOAC in High-Risk Patients With AF
PROTECT-AF
2009, Percutaneous Closure of LAA in atrial fibrillation
RACE 7 ACWAS
2019, Early or Delayed Cardioversion in Recent-Onset Atrial Fibrillation
RACE II
2010, Strict vs Lenient Control of Heart Rate in Atrial Fibrillation
RAFF2
2020, Electrical vs. Pharmacological Cardioversion for ED Patients With Acute AF
RIVER
2020, Rivaroxaban in Patients with Atrial Fibrillation and a Bioprosthetic Mitral Valve
ROCKET AF
2011, Rivaroxaban vs. warfarin in atrial fibrillation
CABG (3)
NOBLE
2016, Percutaneous coronary angioplasty versus coronary artery bypass grafting in treatment of unprotected left main stenosis
STICH
2011, Coronary-Artery Bypass Surgery in Patients with Left Ventricular Dysfunction
TiCAB
2019, Ticagrelor vs. aspirin in patients after coronary artery bypass grafting
Carotid artery stenosis (3)
CREST
2010, Stenting versus CEA in Carotid-Artery Stenosis
NASCET
1998, Carotid Endarterectomy in Patients with Symptomatic Moderate or Severe Stenosis
NASCET (severe stenosis)
1991, Carotid Endarterectomy in Symptomatic Patients with High-Grade Carotid Stenosis
Coronary Artery Disease (51)
AIDA
2017, Bioresorbable Scaffolds versus Metallic Stents in Routine PCI
ARRIVE
2018, Aspirin for Primary Prevention in Adults at Moderate Cardiovascular Risk
ART - CABG
2019, Bilateral versus Single Internal-Thoracic-Artery Grafts at 10 Years
ASPREE
2018, Aspirin for Primary Prevention in Healthy Adults
CANTOS
2017, Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
CAPRIE
1996, Clopidogrel versus aspirin in patients at risk of ischaemic events
CARP
2004, Coronary-Artery Revascularization before Elective Major Vascular Surgery
CHARISMA
2006, Aspirin + clopidogrel vs. aspirin for CVD prevention
CIRT
2018, Low-dose methotrexate for the prevention of atherosclerotic events
COGENT
2010, Clopidogrel with or without Omeprazole in Coronary Artery Disease
COLCOT
2019, Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction
COMPASS
2017, Rivaroxaban with or without ASA in stable CAD
CONSERVE
2019, Selective Referral Using CCTA Versus Direct Referral for Individuals Referred to Invasive Coronary Angiography for Suspected CAD
COURAGE
2007, PCI for stable CAD
DAPT
2014, 12 or 30 months of dual antiplatelet therapy after drug-eluting stents PCI
DECISION-CTO
2019, Percutaneous Coronary Intervention for the Treatment of Chronic Total Occlusion
DEFINE-FLAIR
2017, Use of the Instantaneous Wave-free Ratio or Fractional Flow Reserve in PCI
DIVA
2018, Drug-eluting stents versus bare-metal stents in saphenous vein grafts
EAGLES
2018, Cardiovascular Safety of Smoking Cessation Medications
EUROPA
2003, Efficacy of perindopril in reduction of CV events among patients with stable CAD
EXCEL
2016, Everolimus-eluting stents or bypass surgery for left main coronary artery disease
EXCEL (5 Years)
2019, Five-Year Outcomes after PCI or CABG for Left Main Coronary Disease
FAME
2009, Fractional Flow Reserve versus Angiography for Guiding Percutaneous Coronary Intervention
FAME 2
2012, Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease
FOURIER
2017, Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease
FREEDOM
2012, Percutaneous Coronary Intervention (PCI) vs CABG in Patients with Diabetes and multivessel CAD
HOPE
2000, ACE inhibitors, ramipril in high cardiovascular risk patients
HPS2-THRIVE
2014, Effects of Extended-Release Niacin with Laropiprant in High-Risk Patients
HPS3/TIMI55-REVEAL
2017, Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
ISAR-TRIPLE
2015, Duration of Triple Therapy in Patients Requiring OAC After DES
ISCHEMIA
2019, International Study of Comparative Health Effectiveness With Medical and Invasive Approaches
JUPITER
2008, Rosuvastatin for prevention of CV events
MANAGE
2018, Dabigatran in myocardial injury after non-cardiac surgery
MET-REMODEL
2019, Effect of metformin on left ventricular hypertrophy in patients with CAD without diabetes
MR-INFORM
2019, Magnetic Resonance Perfusion or Fractional Flow Reserve in Coronary Disease
NOBLE
2016, Percutaneous coronary angioplasty versus coronary artery bypass grafting in treatment of unprotected left main stenosis
NORSTENT
2016, Drug-Eluting (DES) or Bare-Metal Stents (BMS) for Coronary Artery Disease
ORBITA
2017, Percutaneous coronary intervention in stable angina
PIONEER AF-PCI
2016, Prevention of bleeding in patients with Atrial fibrillation undergoing PCI
POISE
2008, Metoprolol succinate in patients undergoing surgery
PROMISE
2015, Outcomes of Anatomical versus Functional Testing for Coronary Artery Disease
RE-DUAL PCI
2017, Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation
SYNTAX
2009, PCI vs CABG in severe CAD
THEMIS
2019, Ticagrelor in Patients with Stable Coronary Disease and Diabetes
THEMIS-PCI
2019, Ticagrelor in patients with diabetes and stable CAD with a history of previous PCI
TWILIGHT
2019, Ticagrelor with or without Aspirin in High-Risk Patients after PCI
ULTIMATE- 3 Years
2020, Intravascular Ultrasound Versus Angiography-Guided Drug-Eluting Stent Implantation: Three-year outcomes
VITAL (N3)
2018, N3 fatty acid supplements for prevention of CVD and cancer
VITAL (Vitamin D)
2018, Vitamin D3 for prevention of CVD and cancer
WOEST
2013, Clopidogrel with or without aspirin in patients taking OAC and undergoing PCI
iFR-SWEDEHEART
2017, Instantaneous Wave-free Ratio versus Fractional Flow Reserve to Guide PCI
Heart Failure (43)
A-HeFT
2004, Combination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure
ASCEND-HF
2011, Effect of Nesiritide in Patients with Acute Decompensated Heart Failure
Ancillary DIG
2006, Digoxin in Heart failure with preserved ejection fraction
BLOCK HF
2013, Biventricular versus Right Ventricular Pacing in Heart Failure Patients with Atrioventricular Block
CAPRICORN
2001, Effect of carvedilol on outcome after MI in patients with LV dysfunction
CARE-HF
2005, The Effect of Cardiac Resynchronization on Morbidity and Mortality in Heart Failure
CECCY
2018, Carvedilol for Prevention of Chemotherapy-Related Cardiotoxicity
COAPT
2018, Mitral valve repair in Patients with Heart failure
COAPT-QoL
2019, Health Status After TMVR in Patients With Heart Failure and Secondary Mitral Regurgitation
COMET
2003, Comparison of Carvedilol and Metoprolol in Chronic Heart Failure
COMMANDER HF
2018, Rivaroxaban in Patients with Heart Failure, Sinus Rhythm, and Coronary Disease
CONSENSUS
1987, Effects of Enalapril on Mortality in Severe Congestive Heart Failure
COPERNICUS
2002, Effect of Carvedilol on the Morbidity of Patients With Severe Chronic Heart Failure
CORONA
2007, Rosuvastatin in Older Patients with Systolic Heart Failure
DAPA-HF
2019, Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction
DEFINITE
2004, Prophylactic Defibrillator Implantation in Patients with Nonischemic Dilated Cardiomyopathy
DIG
1997, Digoxin in Heart failure with reduced ejection fraction
DOSE
2011, Furosemide in Acute Decompensated Heart Failure
EMPEROR-Reduced
2020, Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure
EMPHASIS-HF
2011, Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms
ESCAPE
2005, Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness
EVALUATE-HF
2019, Sacubitril-Valsartan vs Enalapril on Aortic Stiffness in Patients with HFrEF
EVEREST Outcome
2007, Tolvaptan in Patients Hospitalized for Worsening Heart Failure
FAIR-HF
2009, Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency
GALACTIC-HF
2020, Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure
HEARTMATE II
2009, Advanced Heart Failure Treated with Continuous-Flow Left Ventricular Assist Device
MERIT-HF
1999, Effect of metoprolol CR/XL in chronic heart failure
MIRACLE
2002, Cardiac Resynchronization in Chronic Heart Failure
MITRA-FR
2018, Percutaneous Repair or Medical Treatment for Secondary Mitral Regurgitation
MOMENTUM 3
2018, Magnetically Levitated Cardiac Pump in Heart Failure
PARADIGM-HF
2014, Angiotensin-neprilysin inhibition versus enalapril in heart failure
PARAGON-HF
2019, Angiotensin–Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction
PIONEER-HF
2018, Angiotensin-neprilysin inhibition in acute decompensated heart failure
RALES
1999, The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
RED-HF
2013, Treatment of Anemia with Darbepoetin Alfa in Systolic Heart Failure
RELAX
2013, Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in HFpEF
RELAX-AHF-2
2019, Effects of Serelaxin in Patients with Acute Heart Failure
REMATCH
2001, Long-Term Use of a Left Ventricular Assist Device for End-Stage Heart Failure
SOLVD
1991, Enalapril for Survival in Patients with Congestive Heart Failure
SURVIVE
2007, Levosimendan in acute decompensated heart failure
TOPCAT
2014, Spironolactone in HFpEF
TRED-HF
2019, Withdrawal of treatment for HF in patients with recovered DCM
VICTORIA
2020, Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction
Hypertension (12)
ACCOMPLISH
2008, Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension in High-Risk Patients
ACCORD BP
2010, Effects of Intensive Blood-Pressure Control in Type 2 Diabetes Mellitus
ALLHAT
2002, Antihypertensive drugs to prevent Heart Attack
Ambulatory BP and Mortality
2018, Ambulatory BP measurements and mortality
Barber Cluster Trial
2018, Barbershop Interventions in Controlling Blood Pressure
CREOLE
2019, Comparison of Dual Therapies for Lowering Blood Pressure in Black Africans
DASH
1997, Effects of Dietary Patterns on Blood Pressure
HYVET
2008, Treatment of Hypertension in Patients 80 Years of Age or Older
OCTAVE
2004, Omapatrilat and enalapril in patients with hypertension
SPRINT
2015, Intensive Versus Standard Blood Pressure Control
SPRINT MIND
2019, Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia
SPYRAL HTN-ON MED
2018, Renal Denervation in Uncontrolled Hypertension
Hypertrophic Cardiomyopathy (1)
EXPLORER-HCM
2020, Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy
Implantable Devices (8)
DANISH
2016, Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure
DAVID
2002, Dual-Chamber Pacing or Ventricular Backup Pacing in Patients With an Implantable Defibrillator
DINAMIT
2004, Prophylactic Use of an Implantable Cardioverter–Defibrillator after Acute Myocardial Infarction
PADIT
2018, Prevention of Arrhythmia Device Infection Trial
PRAETORIAN
2020, Subcutaneous or Transvenous Defibrillator Therapy
RAFT
2010, Cardiac-Resynchronization Therapy for Mild-to-Moderate Heart Failure
RM-ALONE
2019, Protocol for Pacemaker and Defibrillator Surveillance Based on Remote Monitoring Only
WRAP-IT
2019, Antibacterial Envelope to Prevent Cardiac Implantable Device Infection
Lipids (15)
AIM HIGH
2011, Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy
CLEAR Harmony
2019, Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol
CLEAR Wisdom
2019, Efficacy and Safety of Bempedoic Acid Added to Statins in Patients With Hypercholesterolemia and High CV Risk
ENHANCE
2008, Simvastatin with or without ezetimibe in familial hypercholesterolemia
EVAPORATE
2020, Effect of icosapent ethyl on progression of coronary atherosclerosis
LIPID
1998, Pravastatin in patients with coronary heart disease
ORIGIN
2012, n–3 Fatty Acids and Cardiovascular Outcomes in Patients with Dysglycemia
ORION-9
2019, Inclisiran for Heterozygous Familial Hypercholesterolemia
REDUCE-IT
2018, Cardiovascular risk reduction with Icosapent ethyl for hypertriglyceridemia
REDUCE-IT USA
2019, Reduction of Cardiovascular Events With Icosapent Ethyl in USA cohort
SHARP
2011, Lowering LDL cholesterol with simvastatin plus ezetimibe in patients with CKD
SPIRE 1
2017, Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients
SPIRE 2
2017, Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients
TNT
2005, Intensive lipid lowering with atorvastatin in patients with Stable CAD
WOSCOPS
1995, Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia
Marfan Syndrome (1)
AIMS
2019, Irbesartan in Marfan syndrome
Percutaneous Coronary Intervention (11)
COMPLETE
2019, Complete Revascularization with Multivessel PCI for Myocardial Infarction
DANAMI-3 PRIMULTI
2015, Complete revascularisation versus culprit lesion only PCI in STEMI and multivessel disease
DECISION-CTO
2019, Percutaneous Coronary Intervention for the Treatment of Chronic Total Occlusion
GLOBAL LEADERS
2018, Ticagrelor plus aspirin for 1 month, followed by ticagrelor monotherapy for 23 months vs standard DAPT after PCI with DES
NOBLE
2016, Percutaneous coronary angioplasty versus coronary artery bypass grafting in treatment of unprotected left main stenosis
PROTECT II
2012, Impella 2.5 Versus Intra-Aortic Balloon Pump (IABP) in Patients Undergoing High-Risk PCI
RESET
2012, 3-Month Dual Antiplatelet Therapy Following Zotarolimus-Eluting Stent Implantation
SAFARI-STEMI
2019, Safety and Efficacy of Femoral Access vs Radial Access in Patients with STEMI
SMART-CHOICE
2019, P2Y12 Inhibitor Monotherapy vs. Dual Antiplatelet Therapy in Patients Undergoing PCI
STOPDAPT-2
2019, One-Month vs. Standard 12-Month DAPT After Drug-Eluting Stent Implantation
TWILIGHT
2019, Ticagrelor with or without Aspirin in High-Risk Patients after PCI
Pericarditis (1)
ICAP
2013, Colchicine for Acute Pericarditis
Peripheral Arterial Disease (2)
EUCLID
2017, Ticagrelor versus Clopidogrel in Symptomatic Peripheral Artery Disease
VOYAGER PAD
2020, Rivaroxaban in Peripheral Artery Disease After Revascularization
Supraventricular tachycardia (1)
REVERT
2015, Postural modification to the standard Valsalva manoeuvre for emergency treatment of supraventricular tachycardias
Valvular disease (11)
Evolut Low Risk
2019, TAVR with self-expanding valve in low risk patients
GALILEO
2019, Rivaroxaban after Transcatheter Aortic-Valve Replacement
PARTNER 2
2016, Transcatheter or Surgical Aortic Valve Replacement in Intermediate-Risk Patients
PARTNER 3
2019, Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients
PARTNER A
2011, Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients
PARTNER B
2020, Transcatheter Aortic-Valve Implantation (TAVR/TAVI) for Aortic Stenosis in Patients Who Cannot Undergo Surgery
POPular TAVI
2020, Anticoagulation with or without Clopidogrel after Transcatheter Aortic-Valve Implantation
POPular TAVI EU
2020, Aspirin with or without Clopidogrel after Transcatheter Aortic-Valve Implantation
RE-ALIGN
2013, Dabigatran versus warfarin in patients with mechanical heart valves
RECOVERY
2019, Early Surgery or Conservative Care for Asymptomatic Aortic Stenosis
SURTAVI
2017, Surgical AVR or TAVR in intermediate-risk patients
Ventricular Fibrillation (2)
ALIVE
2002, Amiodarone as Compared with Lidocaine for Shock-Resistant Ventricular Fibrillation
ARREST
1999, Amiodarone for Resuscitation after Out-of-Hospital Cardiac Arrest Due to Ventricular Fibrillation
Ventricular Tachycardia (1)
VANISH
2016, Ventricular Tachycardia Ablation versus Escalation of Antiarrhythmic Drugs
Dermatology
Actinic Keratosis (1)
Colchicine cream in AK Trial
2018, 0·5% colchicine cream vs. photodynamic therapy in actinic keratosis
Melanoma (1)
COMBI-V
2015, Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib
Emergency Medicine
Cardiac Arrest (8)
ALIVE
2002, Amiodarone as Compared with Lidocaine for Shock-Resistant Ventricular Fibrillation
ARREST
1999, Amiodarone for Resuscitation after Out-of-Hospital Cardiac Arrest Due to Ventricular Fibrillation
COACT
2019, Coronary Angiography after Cardiac Arrest without ST-Segment Elevation
HACA
2002, Hypothermia in Cardiac Arrest
HYPERION
2019, Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm
Hypothermia in Cardiac Arrest
2002, Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia
PARAMEDIC2
2018, Epinephrine in Out-of-Hospital Cardiac Arrest
TTM
2014, 33 vs. 36°C body temperature after cardiac arrest
ED Testing (1)
RAPID-TnT
2019, Rapid Assessment of Possible ACS in the Emergency Department With High-Sensitivity Troponin T
Trauma (4)
CRASH-2
2010, Effects of tranexamic acid in trauma patients with significant haemorrhage
PAMPer
2018, Prehospital Plasma in Trauma Patients
PROPPR
2015, Transfusion of Plasma, Platelets, and Red Blood Cells in Severe Trauma
RESCUEicp
2016, Decompressive Craniectomy for Traumatic Intracranial Hypertension
Endocrinology
Diabetes Mellitus (26)
ACCORD
2008, Effects of Intensive Glucose Lowering in Type 2 Diabetes
ADVANCE
2008, Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes
ASCEND ASA
2018, Aspirin for primary prevention of CVD in DM
ASCEND N3
2018, N3 fatty acid supplements for primary prevention in DM
CANVAS
2017, Canagliflozin in Type II DM
CREDENCE
2019, Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
Closed Loop Insulin Trial
2018, Closed-loop Insulin Delivery in Non-ICU patients
DECLARE-TIMI 58
2019, Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes
DPP
2002, Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin
EMPA-REG OUTCOMES
2015, Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes
EXSCEL
2017, Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes
LEADER
2016, Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes
Look AHEAD
2013, Cardiovascular Effects of Intensive Lifestyle Intervention in Type 2 Diabetes
Metformin in CKD Cohort
2018, Metformin in CKD
NICE-SUGAR
2009, Intensive versus Conventional Glucose Control in Critically Ill Patients
PIONEER 6
2019, Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes
RABBIT2
2007, Basal-bolus insulin in inpatients with DM
RECORD
2009, Rosiglitazone for CV outcomes in oral agent combination therapy for type 2 diabetes
REWIND
2019, Dulaglutide and cardiovascular outcomes in type 2 diabetes
SAVOR-TIMI
2013, Saxagliptin and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus
SCORED
2021, Sotagliflozin in Patients with Diabetes and Chronic Kidney Disease
STAMPEDE
2012, Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes
SUSTAIN 4
2017, once-weekly semaglutide versus once-daily insulin glargine in type 2 diabetes
TECOS
2015, Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes
VADT
2009, Glucose Control and Vascular Complications in Veterans with Type 2 Diabetes
VERTIS CV
2020, Cardiovascular Outcomes with Ertugliflozin in Type 2 Diabetes
Thyroid Disorder (1)
TABLET
2019, Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception
Gastroenterology
Cirrhosis (6)
ATTIRE
2021, Albumin Infusions in Hospitalized Patients with Cirrhosis
Albumin in SBP
1999, IV albumin in patients with cirrhosis and SBP
Bezafibrate Trial
2018, Bezafibrate in Primary Biliary Cholangitis
Rifaxamin in HE
2013, Rifaxamin in hepatic encephalopathy
Rifaximin after TIPS
2021, Use of Rifaximin in the Prevention of Overt Hepatic Encephalopathy After TIPS
STOPAH
2015, Prednisolone in Alcoholic Hepatitis
Colorectal Cancer (1)
CRCPilotNorway
2020, Colorectal Cancer Screening With Repeated Fecal Immunochemical Test Versus Sigmoidoscopy
Gastrointestinal Bleeding (4)
COGENT
2010, Clopidogrel with or without Omeprazole in Coronary Artery Disease
POP-UP
2016, Pantoprazole or Placebo for Stress Ulcer Prophylaxis
SUP-ICU
2018, Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU
Transfusion in UGIB
2013, Transfusion Strategies for Acute Upper Gastrointestinal Bleeding
Nutrition (2)
EFFORT
2019, Individualised nutritional support in medical inpatients at nutritional risk
TARGET
2018, Energy-Dense versus Routine Enteral Nutrition in the Critically Ill
Obesity (1)
CAMELLIA-TIMI 61
2019, Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients
Pancreatitis (1)
PANTER
2010, A Step-up Approach or Open Necrosectomy for Necrotizing Pancreatitis
Geriatric Medicine
Delirium (1)
MIND-USA
2018, Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness
Gynaecology
Bacterial Vaginosis (1)
LACTIN-V
2020, Lactin-V to Prevent Recurrence of Bacterial Vaginosis
Hematology/Oncology
Anemia (5)
CHOIR
2006, Erythropoetin for anemia in non-dialysis CKD
FAIR-HF
2009, Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency
RED-HF
2013, Treatment of Anemia with Darbepoetin Alfa in Systolic Heart Failure
TREAT
2009, Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney Disease
TRICC
1999, Transfusion requirements in critical care
Cancer (14)
AGE
2006, Mammographic screening from age 40 years
ATLAS
2013, 10 years vs. 5 years of tamoxifen in breast cancer
COLONPREV
2012, FIT vs. colonoscopy for colon cancer screening
CROWN
2020, Lorlatinib or Crizotinib in Advanced ALK-Positive Lung Cancer
EMILIA
2012, Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer
ERSPC
2009, Screening and Prostate-Cancer Mortality
FREGAT
2019, Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer
IALT
2004, Cisplatin-based adjuvant chemotherapy in patients with completely resected NSCLC
Metachronous Gastric Trial
2018, H-Pylori treatment in Metachronous Gastric Cancer
NELSON
2018, CT scan for screening lung cancer
NLST
2011, Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening
NSABP P-1
1998, Tamoxifen for Prevention of Breast Cancer
PACIFIC
2018, Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC
STAR
2006, Effects of Tamoxifen vs Raloxifene on the Risk of Developing Invasive Breast Cancer
GVHD (1)
REACH2
2020, Ruxolitinib for Glucocorticoid-Refractory Acute Graft-versus-Host Disease
Sickle Cell Disease (1)
MSH
1995, Effect of Hydroxyurea on the Frequency of Painful Crises in Sickle Cell Anemia
TTP (2)
HERCULES
2019, Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura
TITAN
2016, Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura
Venous Thromboembolism (24)
ADJUST PE
2014, Age Adjusted D Dimer for PE
AMPLIFY
2013, Apixaban for VTE
ANNEXA
2015, Andexanet for reversal of Factor Xa Inhibitors
ATTRACT
2017, Pharmacomechanical Catheter-Directed Thrombolysis for Deep-Vein Thrombosis
AVERT
2018, Apixaban to Prevent Venous Thromboembolism (VTE) in Patients with Cancer
CASSINI
2019, Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer
CLOT
2003, LMWH vs a coumarin for the prevention of recurrent VTE in patients with cancer
Caravaggio
2020, Apixaban for the Treatment of Venous Thromboembolism Associated with Cancer
EINSTEIN PE
2012, Rivaroxaban for Acute PE
EPCAT I
2013, Aspirin Versus LMWH for Extended VTE Prophylaxis After Total Hip Arthroplasty
EPCAT II
2018, Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty
Hokusai VTE Cancer
2018, Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism
MAGELLAN
2013, Rivaroxaban for Thromboprophylaxis in Acutely Ill Medical Patients
MARINER
2018, Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness
MEDENOX
1999, Enoxaparin for Prevention of VTE in Acutely Ill Medical Patients
MOPETT
2013, Low-dose tPA for submassive PE
PEITHO
2014, Fibrinolysis for Patients with Intermediate-Risk Pulmonary Embolism
PREPIC
1998, Vena Caval Filters in Prevention of Pulmonary Embolism in Patients with Proximal Deep-Vein Thrombosis
PREPIC 2
2015, Effect of a Retrievable IVC Filter + Anticoagulation vs Anticoagulation Alone on Risk of Recurrent Pulmonary Embolism
PREVENT
2019, Adjunctive Intermittent Pneumatic Compression for Venous Thromboprophylaxis
RE-COVER
2009, Dabigatran versus Warfarin in the Treatment of Acute Venous Thromboembolism
SELECT-D
2018, Rivaroxaban vs LMWH (Dalteparin) in Patients With Cancer With VTE
SOME
2015, Cancer screening in unprovoked VTE
WARFASA
2012, Aspirin for Recurrent VTE
Infectious disease
COVID-19 (12)
ACTIV-3
2020, Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19
ACTT-1
2020, Remdesivir for the Treatment of Covid-19
ACTT-2
2020, Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19
BACC bay
2020, Efficacy of Tocilizumab in Patients Hospitalized with Covid-19
BCN-PEP-CoV2
2021, A Cluster-Randomized Trial of Hydroxychloroquine for Prevention of Covid-19
COVE
2020, Efficacy and Safety of the mRNA-1273 (Moderna) SARS-CoV-2 Vaccine
COVID-19 PEP
2020, Hydroxychloroquine as Postexposure Prophylaxis for Covid-19
EMPACTA
2020, Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia
PFIZER COVID-19
2020, Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
PlasmAr
2020, Convalescent Plasma in Covid-19 Severe Pneumonia
RECOVERY
2020, Dexamethasone in Hospitalized Patients with Covid-19
REGN-COV2
2020, REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19
Cellulitis (1)
ICTOC
2020, Compression Therapy to Prevent Recurrent Cellulitis of the Leg
Endocarditis (1)
EASE
2012, Early Surgery versus Conventional Treatment for Infective Endocarditis
HIV (4)
ANRS IPERGAY
2015, On-demand preexposure prophylaxis in men at high risk for HIV-1 infection
AZT
1987, Azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex
HPTN 052
2011, Prevention of HIV-1 Infection with Early Antiretroviral Therapy
INSIGHT START
2015, INSIGHT START: Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection
Hepatitis C (2)
DAHHS2
2019, Treatment of acute hepatitis C with 8 weeks of grazoprevir plus elbasvir
VALENCE
2014, Sofosbuvir and ribavirin in HCV
Infections (14)
CAPSTONE-1
2018, Baloxavir Marboxil for Uncomplicated Influenza
EPIC
2019, Once-Daily Plazomicin for Complicated Urinary Tract Infections
Fidaxomicin in C. diff Infection
2011, Fidaxomicin versus vancomycin for Clostridium difficile infection
HEAT
2015, Acetaminophen for Fever in Critically Ill Patients with Suspected Infection
INHALE
2019, Inhaled amikacin in mechanically ventilated patients with Gram-negative pneumonia
MERINO
2018, Piperacillin-Tazobactam vs Meropenem in Ceftriaxone resistant Infections
OPTIC
2019, Omadacycline for Community-Acquired Bacterial Pneumonia
PLACIDE
2013, Lactobacilli and bifidobacteria in preventing antibiotic-associated and C.diff diarrhea
POET
2018, IV vs PO Antibiotics in Infective Endocarditis
PREVENT TB
2011, Three Months of Rifapentine and Isoniazid for Latent Tuberculosis Infection
PROACT
2018, Procalcitonin in Lower Respiratory Tract Infections
PRORATA
2010, Procalcitonin guided antibiotic therapy in critically ill patients
Project CLEAR
2019, Decolonization to Reduce Postdischarge Infection Risk among MRSA Carriers
STOP-IT
2015, Short-Course Antimicrobial Therapy for Intraabdominal Infection
Osteomyelitis (1)
OVIVA
2019, Oral versus Intravenous Antibiotics for Bone and Joint Infection
Sepsis (13)
ADRENAL
2018, Glucocorticoids in Septic Shock
ALBIOS
2014, Albumin in Severe Sepsis and Septic Shock
APROCCHSS
2018, Hydrocortisone + Fludrocortisone in Septic Shock
BICAR-ICU
2018, Sodium Bicarbonate in Severe Metabolic Acidaemia
CITRIS-ALI
2019, Effect of Vitamin C Infusion in Patients With Sepsis and ARDS
CORTICUS
2008, Hydrocortisone Therapy for Patients with Septic Shock
HYPRESS
2016, Effect of Hydrocortisone on Development of Shock Among Patients With Severe Sepsis
PROWESS-SHOCK
2012, Activated protein C (DrotAA) in Sepsis
ProCESS
2014, A Randomized Trial of Protocol-Based Care for Early Septic Shock
Rivers Trial
2001, Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock
SALT-ED
2018, Balanced crystalloids versus saline in non-critically ill adults
SEPSISPAM
2014, High versus low blood-pressure target in patients with septic shock
TRISS
2014, Restrictive vs Liberal Transfusion in Septic Shock
Nephrology
Cardiorenal Syndrome (1)
CARRESS HF
2012, Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome
Dialysis (8)
AKIKI
2016, Renal Replacement Therapy in ICU
ATN
2008, Intensity of renal support in critically ill patients with acute kidney injury
AURORA
2009, Rosuvastatin and Cardiovascular Events in Patients Undergoing Hemodialysis
EVOLVE
2012, Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing Dialysis
IDEAL
2010, Early versus Late Dialysis in Patients with ESRD
IDEAL-ICU
2018, Timing of renal-replacement therapy in patients with acute kidney injury and sepsis
PIVOTAL
2019, Intravenous Iron in Patients Undergoing Maintenance Hemodialysis
RENAL
2009, Intensity of Continuous Renal-Replacement Therapy in Critically Ill Patients
Lupus Nephritis (1)
BLISS-LN
2020, Belimumab in Lupus Nephritis
2020, Belimumab in Lupus Nephritis
Nephropathy (9)
DAPA-CKD
2020, Dapagliflozin in Patients with Chronic Kidney Disease
IDNT
2001, Irbesartan in diabetic nephropathy
PERL
2020, Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes
PRESERVE
2018, Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine
RENAAL
2001, Losartan in diabetic nephropathy
SONAR
2019, Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease
STOP-IgAN
2015, Intensive Supportive Care plus Immunosuppression in IgA Nephropathy
TREAT
2009, Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney Disease
VA NEPHRON-D
2013, Combined angiotensin inhibition for the treatment of diabetic nephropathy
Renal Artery Stenosis (2)
ASTRAL
2009, Revascularization versus Medical Therapy for Renal-Artery Stenosis
CORAL
2014, Stenting and Medical Therapy for Atherosclerotic Renal-Artery Stenosis
Neurology
Cerebral Venous Thrombosis (1)
RE-SPECT CVT
2019, Dabigatran Etexilate vs Dose-Adjusted Warfarin in Patients With Cerebral Venous Thrombosis
Headache (1)
STRIVE
2017, Erenumab in Episodic Migraine
Myasthenia Gravis (1)
MGTX
2016, Thymectomy in Myasthenia Gravis
Parkinson's Disease (1)
LEAP
2019, Early vs Delayed Levodopa in Parkinson’s Disease
Status Epilepticus (1)
RAMPART
2012, Intramuscular versus Intravenous Therapy for Prehospital Status Epilepticus
Stroke (27)
ACTIVE A
2009, Effect of Clopidogrel Added to Aspirin in Patients with Atrial Fibrillation
ACTIVE W
2006, Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation
ASSORT
2017, Early Versus Delayed Statin Therapy in Patients With Acute Ischemic Stroke
BRIDGE
2015, Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation
CHANCE
2013, Clopidogrel with aspirin in acute minor stroke or transient ischemic attack
CLOSE
2017, Patent Foramen Ovale Closure or Anticoagulation vs. Antiplatelets after Stroke
CLOSURE I
2012, Closure or Medical Therapy for Cryptogenic Stroke with Patent Foramen Ovale
DAWN
2018, Mechanical Thrombectomy 6 to 24 Hours after Stroke
DEFUSE-3
2018, Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging
ECASS III
2008, Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke
ESPIRIT
2006, Aspirin plus dipyridamole versus aspirin alone after ischemic stroke
EXTEND
2019, Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke
EXTEND-IA TNK
2018, Tenecteplase vs Alteplase in Ischemic Stroke
Gore REDUCE
2017, Patent Foramen Ovale Closure or Antiplatelet Therapy for Cryptogenic Stroke
MATCH
2004, Aspirin and clopidogrel compared with clopidogrel alone after stroke
MR CLEAN
2015, Intraarterial Treatment for Acute Ischemic Stroke
MR RESCUE
2013, A Trial of Imaging Selection and Endovascular Treatment for Ischemic Stroke
NAVIGATE ESUS
2018, Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source
POINT
2018, Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA
PRoFESS
2008, Aspirin and Extended-Release Dipyridamole versus Clopidogrel for Recurrent Stroke
RE-SPECT ESUS
2019, Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source
RESPECT
2013, Closure of Patent Foramen Ovale versus Medical Therapy after Cryptogenic Stroke
SOCRATES
2016, Ticagrelor versus aspirin in acute stroke or TIA
SPARCL
2006, High-dose atorvastatin after stroke or transient ischemic attack (TIA)
THALES
2020, Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA
Treat Stroke to Target
2019, A Comparison of Two LDL Cholesterol Targets after Ischemic Stroke
WAKE-UP
2018, MRI guided thrombolysis with alteplase in stroke with unknown time of onset
Orthopedics
Total Hip Arthroplasty (3)
EPCAT I
2013, Aspirin Versus LMWH for Extended VTE Prophylaxis After Total Hip Arthroplasty
EPCAT II
2018, Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty
PANSAID
2019, Paracetamol and Ibuprofen on Morphine Consumption in the Total Hip Arthroplasty
Psychiatry
Alcohol Dependence (1)
COMBINE
2006, Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence
Bipolar Disorder (2)
BALANCE
2010, Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder
STEP-BD
2007, Adjunctive Antidepressant Treatment for Bipolar Depression
Panic Disorder (1)
CBT, Imipramine in Panic Disorder
2000, Cognitive-Behavioral Therapy, Imipramine, or Their Combination for Panic Disorder
Pulmonary/Critical care
ARDS (4)
ACURASYS
2010, Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome
ART
2017, Lung Recruitment and Titrated PEEP vs Low PEEP in ARDS
PROSEVA
2013, Prone Positioning in Severe Acute Respiratory Distress Syndrome (ARDS)
ROSE
2019, Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome
Asthma (4)
AMAZES
2017, Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma
EXTRA
2011, Omalizumab in Severe Allergic Asthma
Novel START
2019, Controlled Trial of Budesonide–Formoterol as Needed for Mild Asthma
SMART
2006, Usual pharmacotherapy for asthma versus usual pharmacotherapy plus salmeterol
COPD (8)
ASCENT-COPD
2019, Effect of Aclidinium Bromide on Major CV Events and Exacerbations in Patients With COPD
BLOCK COPD
2019, Metoprolol for the Prevention of Acute Exacerbations of COPD
FLAME
2016, LABA + LAMA vs LABA + ICS for COPD
LOTT
2016, Long-Term Oxygen for COPD with Moderate Desaturation
NETT
2003, Lung-volume-reduction surgery versus medical therapy for severe emphysema
REDUCE
2013, Short term steroids in COPD exacerbation
TORCH
2007, Salmeterol and Fluticasone Propionate in Chronic Obstructive Pulmonary Disease
UPLIFT
2008, Tiotropium in Chronic Obstructive Pulmonary Disease
Endotracheal Intubation (1)
CHECK-UP
2018, Checklist for Endotracheal Intubation of Critically Ill Adults
ICU (5)
CENSER
2019. Early Use of Norepinephrine in Septic Shock Resuscitation
CLASSIC
2016, Restricting volumes of resuscitation fluid in adults with septic shock after initial management
HEAT
2015, Acetaminophen for Fever in Critically Ill Patients with Suspected Infection
REFRESH
2018, Restricted fluid resuscitation in suspected sepsis associated hypotension
VIOLET
2019, Early High-Dose Vitamin D3 for Critically Ill, Vitamin D Deficient Patients
Interstitial Lung Disease (2)
INBUILD
2019, Nintedanib in Progressive Fibrosing Interstitial Lung Diseases
INPULSIS
2014, Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis
Mechanical Ventilation (4)
HIGH-WEAN
2019, Postextubation High-Flow Nasal Oxygen + Noninvasive Ventilation vs High-Flow Nasal Oxygen Alone
PReVENT
2018, Low vs Intermediate Tidal Volume Strategy in ICU Patients Without ARDS
PreVent
2019, Bag-Mask Ventilation during Tracheal Intubation of Critically Ill Adults
SPICE III
2019, Early Sedation with Dexmedetomidine in Critically Ill Patients
Obstructive Sleep Apnea (1)
SAVE
2016, CPAP for Prevention of Cardiovascular Events in Obstructive Sleep Apnea
Pulmonary Arterial Hypertension (1)
BREATHE-1
2002, Bosentan Therapy for Pulmonary Arterial Hypertension
Pulmonary Edema (1)
3CPO
2008, Noninvasive Ventilation in Acute Cardiogenic Pulmonary Edema
Sepsis (3)
CENSER
2019. Early Use of Norepinephrine in Septic Shock Resuscitation
CLASSIC
2016, Restricting volumes of resuscitation fluid in adults with septic shock after initial management
REFRESH
2018, Restricted fluid resuscitation in suspected sepsis associated hypotension
Shock (10)
ANDROMEDA-SHOCK
2019, Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on Mortality in Septic Shock
ATHOS-3
2017, Angiotensin II for the Treatment of Vasodilatory Shock
CENSER
2019. Early Use of Norepinephrine in Septic Shock Resuscitation
CITRIS-ALI
2019, Effect of Vitamin C Infusion in Patients With Sepsis and ARDS
CLASSIC
2016, Restricting volumes of resuscitation fluid in adults with septic shock after initial management
CRISTAL
2013, Effects of fluid resuscitation with colloids vs. crystalloids on mortality in hypovolemic shock
ProCESS
2014, A Randomized Trial of Protocol-Based Care for Early Septic Shock
REFRESH
2018, Restricted fluid resuscitation in suspected sepsis associated hypotension
Rivers Trial
2001, Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock
65
2020, Effect of Reduced Exposure to Vasopressors on Mortality in Critically ill Patients
Rheumatology
Antiphospholipid Syndrome (1)
TRAPS
2018, Rivaroxaban vs. warfarin in high-risk patients with antiphospholipid syndrome
Arthritis (4)
BeSt
2005, DMARD with prednisone or infliximab in RA
LESS
2014, Epidural Glucocorticoid Injections for Spinal Stenosis
METEOR
2013, Surgery vs Physical Therapy for a Meniscal Tear and Osteoarthritis
PT vs Steroids in OA
2020, Physical Therapy versus Glucocorticoid Injection for Osteoarthritis of the Knee
Vasculitis (2)
CYCLOPS
2009, Pulse vs daily oral cyclophosphamide for induction of remission in ANCA vasculitis
RAVE
2010, Rituximab versus cyclophosphamide for ANCA-associated vasculitis
Surgery
Abdominal Aortic Aneurysm (2)
EVAR-1
2010, Endovascular versus Open Repair of Abdominal Aortic Aneurysm
OVER
2019, Open versus Endovascular Repair of Abdominal Aortic Aneurysm
Appendicitis (1)
CODA
2020, Antibiotics vs. Appendectomy for Appendicitis
Arthroplasty (1)
HEALTH
2019, Total Hip Arthroplasty or Hemiarthroplasty for Hip Fracture
CABG (1)
MYRIAD
2019, Volatile Anesthetics versus Total Intravenous Anesthesia for Cardiac Surgery
Gastric Bypass Surgery (1)
STAMPEDE
2012, Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes
Lung Volume Reduction Surgery (1)
NETT
2003, Lung-volume-reduction surgery versus medical therapy for severe emphysema
Lymphadenectomy (1)
LION
2019, Lymphadenectomy in Patients with Advanced Ovarian Neoplasms
Meniscal Tear (1)
FIDELITY
2013, Arthroscopic Partial Meniscectomy versus Sham Surgery for a Degenerative Meniscal Tear
Necrosectomy (1)
PANTER
2010, A Step-up Approach or Open Necrosectomy for Necrotizing Pancreatitis
Pre-op (1)
POISE-2
2014, Aspirin in Patients Undergoing Noncardiac Surgery
Transfusion (1)
TRICS III
2018, Six-Month Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery
Venous Thromboembolism (1)
PRONOMOS
2020, Rivaroxaban or Enoxaparin in Nonmajor Orthopedic Surgery