| Acute Coronary Syndrome | CAST I | 1991, Antiarrhythmics post-MI |
| ESSENCE | 1997, Enoxaparin vs Unfractionated Heparin for UA/NSTEMI | |
| CURE | 2001, Effects of Clopidogrel plus Aspirin in Patients with NSTEMI | |
| EPHESUS | 2003, Eplerenone in patients with LV dysfunction after MI | |
| COMMIT | 2005, Metoprolol after acute MI | |
| ACT | 2011, Acetylcysteine in Coronary Angiography | |
| ATLAS ACS-2 | 2012, Rivaroxaban in Acute Coronary Syndrome | |
| CHAMPION PHOENIX | 2013, Cangrelor vs Clopidogrel in PCI | |
| CULPRIT-SHOCK | 2018, Culprit lesion vs multivessel PCI in ACS with cardiogenic shock | |
| SCOT-HEART | 2018, CTA vs standard care in preventing MI | |
| Anemia | CHOIR | 2006, Erythropoetin for anemia in non-dialysis CKD |
| Aortic Stenosis | PARTNER A | 2011, Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients |
| Arthritis | BeSt | 2005, DMARD with prednisone or infliximab in RA |
| EXTRA | 2011, Omalizumab in Severe Allergic Asthma | |
| METEOR | 2013, Surgery vs Physical Therapy for a Meniscal Tear and Osteoarthritis | |
| LESS | 2014, Epidural Glucocorticoid Injections for Spinal Stenosis | |
| ARDS | PROSEVA | 2013, Prone Positioning in Severe Acute Respiratory Distress Syndrome (ARDS) |
| ART | 2017, Lung Recruitment and Titrated PEEP vs Low PEEP in ARDS | |
| Atrial Fibrillation | AFFIRM | 2002, Rate control vs Rhythm control in Atrial Fibrillation |
| PROTECT-AF | 2009, Percutaneous Closure of LAA in atrial fibrillation | |
| RACE II | 2010, Strict vs Lenient Control of Heart Rate in Atrial Fibrillation | |
| ROCKET AF | 2011, Rivaroxaban vs. warfarin in atrial fibrillation | |
| ARISTOTLE | 2011, Apixaban vs. warfarin in atrial fibrillation | |
| ORBIT-AF | 2013, Aspirin and OAC in Atrial Fibrillation | |
| CABANA | 2018, Catheter Ablation for Atrial Fibrillation | |
| CASTLE-AF | 2018, Catheter Ablation for Atrial Fibrillation with Heart Failure | |
| Cardiac Arrest | HACA | 2002, Hypothermia in Cardiac Arrest |
| TTM | 2014, 33 vs. 36°C body temperature after cardiac arrest | |
| PARAMEDIC2 | 2018, Epinephrine in Out-of-Hospital Cardiac Arrest | |
| Coronary Artery Disease | LIPID | 1998, Pravastatin in patients with coronary heart disease |
| HOPE | 2000, ACE inhibitors, ramipril in high cardiovascular risk patients | |
| CHARISMA | 2006, Aspirin + clopidogrel vs. aspirin for CVD prevention | |
| COURAGE | 2007, PCI for stable CAD | |
| JUPITER | 2008, Rosuvastatin for prevention of CV events | |
| POISE | 2008, Metoprolol succinate in patients undergoing surgery | |
| SYNTAX | 2009, PCI vs CABG in severe CAD | |
| FREEDOM | 2012, Percutaneous Coronary Intervention (PCI) vs CABG in Patients with Diabetes and multivessel CAD | |
| DAPT | 2014, 12 or 30 months of dual antiplatelet therapy after drug-eluting stents PCI | |
| EXCEL | 2016, Everolimus-Eluting Stents or Bypass Surgery for Left Main CAD | |
| COMPASS | 2017, Rivaroxaban with or without ASA in stable CAD | |
| MANAGE | 2018, Dabigatran in myocardial injury after non-cardiac surgery | |
| VITAL (Vitamin D) | 2018, Vitamin D3 for prevention of CVD and cancer | |
| VITAL (N3) | 2018, N3 fatty acid supplements for prevention of CVD and cancer | |
| REDUCE-IT | 2018, Cardiovascular risk reduction with Icosapent ethyl for hypertriglyceridemia | |
| ASPREE | 2018, Aspirin for Primary Prevention in Healthy Adults | |
| ARRIVE | 2018, Aspirin for Primary Prevention in Adults at Moderate Cardiovascular Risk | |
| COPD | FLAME | 2016, LABA + LAMA vs LABA + ICS for COPD |
| REDUCE | 2013, Short term steroids in COPD exacerbation | |
| Cirrhosis | Albumin in SBP | 1999, IV albumin in patients with cirrhosis and SBP |
| Rifaximin in HE | 2013, Rifaxamin in hepatic encephalopathy | |
| STOPAH | 2015, Prednisolone in Alcoholic Hepatitis | |
| Bezafibrate Trial | 2018, Bezafibrate in Primary Biliary Cholangitis | |
| Cancer | Metachronous Gastric Trial | 2018, H-Pylori treatment in Metachronous Gastric Cancer |
| Carotid artery stenosis | CREST | 2010, Stenting versus CEA in Carotid-Artery Stenosis |
| Depression | SADHART | 2002, Sertraline for depression after ACS |
| Diabetes Mellitus | RABBIT2 | 2007, Basal-bolus insulin in inpatients with DM |
| EMPA-REG OUTCOMES | 2015, Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes | |
| CANVAS | 2017, Canagliflozin in Type II DM | |
| ASCEND ASA | 2018, Aspirin for primary prevention of CVD in DM | |
| ASCEND N3 | 2018, N3 fatty acid supplements for primary prevention in DM | |
| Metformin in CKD Cohort | 2018, Metformin in CKD | |
| Closed Loop Insulin Trial | 2018, Closed-loop Insulin Delivery in Non-ICU patients | |
| Dialysis | IDEAL | 2010, Early versus Late Dialysis in Patients with ESRD |
| AKIKI | 2016, Renal Replacement Therapy in ICU | |
| Gastrointestinal Bleeding | POP-UP | 2016, Pantoprazole or Placebo for Stress Ulcer Prophylaxis |
| SUP-ICU | 2018, Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU | |
| Hypertension | ALLHAT | 2002, Antihypertensive drugs to prevent Heart Attack |
| SPYRAL HTN-ON MED | 2018, Renal Denervation in Uncontrolled Hypertension | |
| Barber Cluster Trial | 2018, Barbershop Interventions in Controlling Blood Pressure | |
| Ambulatory BP and Mortality | 2018, Ambulatory BP measurements and mortality | |
| Heart Failure | DIG | 1997, Digoxin in Heart failure with reduced ejection fraction |
| COMET | 2003, Comparison of Carvedilol and Metoprolol in Chronic Heart Failure | |
| Ancillary DIG | 2006, Digoxin in Heart failure with preserved ejection fraction | |
| DOSE | 2011, Furosemide in Acute Decompensated Heart Failure | |
| BLOCK HF | 2013, Biventricular versus Right Ventricular Pacing in Heart Failure Patients with AV Block | |
| TOPCAT | 2014, Spironolactone in HFpEF | |
| COAPT | 2018, Mitral valve repair in Patients with Heart failure | |
| PIONEER-HF | 2018, Angiotensin-neprilysin inhibition in acute decompensated heart failure | |
| Headache | STRIVE | 2017, Erenumab in Episodic Migraine |
| Infections | PRORATA | 2010, Procalcitonin guided antibiotic therapy in critically ill patients |
| Fidaxomicin in C. diff Infection | 2011, Fidaxomicin versus vancomycin for Clostridium difficile infection | |
| VALENCE | 2014, Sofosbuvir and ribavirin in HCV | |
| PROACT | 2018, Procalcitonin in Lower Respiratory Tract Infections | |
| POET | 2018, IV vs PO Antibiotics in Infective Endocarditis | |
| MERINO | 2018, Piperacillin-Tazobactam vs Meropenem in Ceftriaxone resistant Infections | |
| CAPSTONE-1 | 2018, Baloxavir Marboxil for Uncomplicated Influenza | |
| Sepsis | PROWESS-SHOCK | 2012, Activated protein C (DrotAA) in Sepsis |
| TRISS | 2014, Restrictive vs Liberal Transfusion in Septic Shock | |
| ALBIOS | 2014, Albumin in Severe Sepsis and Septic Shock | |
| SALT-ED | 2018, Balanced crystalloids versus saline in non-critically ill adults | |
| ADRENAL | 2018, Glucocorticoids in Septic Shock | |
| APROCCHSS | 2018, Hydrocortisone + Fludrocortisone in Septic Shock | |
| BICAR-ICU | 2018, Sodium Bicarbonate in Severe Metabolic Acidaemia | |
| Stroke | SPARCL | 2006, High-dose atorvastatin after stroke or transient ischemic attack (TIA) |
| SOCRATES | 2016, Ticagrelor versus aspirin in acute stroke or TIA | |
| EXTEND-IA TNK | 2018, Tenecteplase vs Alteplase in Ischemic Stroke | |
| WAKE-UP | 2018, MRI guided thrombolysis with alteplase in stroke with unknown time of onset | |
| Screening | AGE | 2006, Mammographic screening from age 40 years |
| COLONPREV | 2012, FIT vs. colonoscopy for colon cancer screening | |
| NELSON | 2018, CT scan for screening lung cancer | |
| Smoking | EAGLES | 2018, Cardiovascular Safety of Smoking Cessation Medications |
| Thromboembolism | WARFASA | 2012, Aspirin for Recurrent VTE |
| EINSTEIN PE | 2012, Rivaroxaban for Acute PE | |
| AMPLIFY | 2013, Apixaban for VTE | |
| MOPETT | 2013, Low-dose tPA for submassive PE | |
| ADJUST PE | 2014, Age Adjusted D Dimer for PE | |
| ANNEXA | 2015, Andexanet for reversal of Factor Xa Inhibitors | |
| SOME | 2015, Cancer screening in unprovoked VTE | |
| AVERT | 2018, Apixaban to Prevent Venous Thromboembolism in Patients with Cancer | |
| Trauma | PAMPer | 2018, Prehospital Plasma in Trauma Patients |