FIDELITY Trial: Arthroscopic Partial Meniscectomy versus Sham Surgery for a Degenerative Meniscal Tear

2013, Arthroscopic Partial Meniscectomy versus Sham Surgery for a Degenerative Meniscal Te

MSH Trial: Effect of Hydroxyurea on the Frequency of Painful Crises in Sickle Cell Anemia

MSH Trial: 1995, Effect of Hydroxyurea on the Frequency of Painful Crises in Sickle Cell A

MET-REMODEL Trial: Metformin on LVH in patients with CAD without diabetes

2019, MET-REMODEL Trial: Metformin on left ventricular hypertrophy in patients with corona

ASCENT COPD Trial: Effect of Aclidinium Bromide on Major Cardiovascular Events and Exacerbations in High-Risk Patients With COPD

2019, ASCENT-COPD Trial: Effect of Aclidinium Bromide on Major Cardiovascular Events and E

VADT Trial: Glucose Control and Vascular Complications in Veterans with Type 2 Diabetes

2009, VADT Trial: Glucose Control and Vascular Complications in Veterans with Type 2 Diabe

CAPRICORN Trial: Effect of carvedilol on outcome after MI in patients with LV dysfunction

2001, Effect of carvedilol on outcome after MI in patients with LV dysfunction. Source

CENSER Trial: Early Use of Norepinephrine in Septic Shock Resuscitation

CENSER Trial 2019. Early Use of Norepinephrine in Septic Shock Resuscitation. Source: AJRC

ALIVE Trial: Amiodarone as Compared with Lidocaine for Shock-Resistant Ventricular Fibrillation

2002, ALIVE Trial Visual Summary: Amiodarone as Compared with Lidocaine for Shock-Resistan

ARREST Trial: Amiodarone for Resuscitation after Out-of-Hospital Cardiac Arrest Due to Ventricular Fibrillation

ARREST Trial: 1999, Amiodarone for Resuscitation after Out-of-Hospital Cardiac Arrest Due

RE-SPECT ESUS Trial: Dabigatran for Prevention of Recurrent Stroke after Cryptogenic Stroke

2019, RE-SPECT ESUS Trial Summary: Dabigatran for Prevention of Stroke after Embolic Strok

NLST Trial: Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening

Source: NEJM

OCTAVE Trial: Omapatrilat and enalapril in patients with hypertension

Source: American journal of hypertension

CREDENCE Trial: Canagliflozin and renal outcomes in type II diabetes and nephropathy

CREDENCE Trial Visual Abstract In CREDENCE trial, the authors objective was to assess the

ALCOHOL-AF Trial: Impact of Alcohol Abstinence in Moderate Drinkers With Atrial Fibrillation

The goal of ALCOHOL-AF trial was to assess effect of alcohol abstinence on recurrence of A

TABLET Trial (2019): Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception

TABLET Trial Summary: Dhillon-Smith R et al. randomized 952 women with positive testing fo

LEAP trial (2019): Early vs Delayed Levodopa in Parkinson’s Disease

LEAP Trial Summary: The LEAP trial was a Multicenter, randomized, double-blind, placebo-co

PARTNER 3 Trial (2019): Transcatheter Aortic-Valve Replacement With a Balloon-Expandable Valve in Low-Risk Patients

PARTNER 3 Trial Summary: Mack MJ et al. randomized 1000 patients (mean age, 73 years), mal

PIVOTAL Trial (2019): Intravenous Iron in Patients Undergoing Maintenance Hemodialysis

PIVOTAL Trial Summary: Macdougall et al. randomized 2141 adults undergoing maintenance HD

CARRESS-HF Trial (2012): Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome

CARRESS HF Trial Summary: Bart et al. randomized 188 patients with decompensated acute hea

Effectiveness and safety of 0·5% colchicine cream vs. photodynamic therapy in the treatment of actinic keratosis

Trial Summary: Effectiveness and safety of 0•5% colchicine cream vs. photodynamic therap

PreVent Trial (2019): Bag-Mask Ventilation during Tracheal Intubation of Critically Ill Adults

PreVent Trial Summary: Casey et al. randomized 401 adults (age, ≥18 years) undergoing in

CHANCE Trial (2013): Clopidogrel with aspirin in acute minor stroke or transient ischemic attack

CHANCE Trial Summary: Wang et al. randomized 5,170 patients (≥40 years) with either mino

HYPRESS Trial (2016): Effect of Hydrocortisone on Development of Shock Among Patients With Severe Sepsis

HYPRESS Trial Summary: Keh D, et al. randomized 380 patients with sepsis defined by ≥2 S

SEPSISPAM Trial (2014): High versus low blood-pressure target in patients with septic shock

SEPSISPAM Trial Summary: Asfar P et al. randomized 776 patients ≥18 years with septic sh

BRIDGE Trial (2015): Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation

BRIDGE Trial Summary: Douketis JD et al. randomized 1,884 patients on warfarin (INR 2-3 fo

VALIANT Trial (2003): Valsartan, Captopril, or Both in Myocardial Infarction

VALIANT Trial Summary: Pfeffer et al. randomized 14,703 patients with acute MI within pri

Project CLEAR Trial (2019): Decolonization to Reduce Postdischarge Infection Risk among MRSA Carriers

Project CLEAR trial summary: Huang et al. randomized 2,141 patients colonized with MRSA to

POINT Trial (2018): Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA

POINT Trial Summary: Johnston et al. randomized 4,881 patients who presented with low risk

PLACIDE Trial (2013): Lactobacilli and bifidobacteria in preventing antibiotic-associated and C.diff diarrhea

PLACIDE trial summary: Allen SJ et al. conducted a multicenter, randomized, double blind,

PANSAID Trial (2019): Paracetamol and Ibuprofen on Morphine Consumption in the Total Hip Arthroplasty

PANSAID Trial Summary: Hojgaard et al. randomized 556 patients who were schedule

COMMANDER HF Trial (2018): Rivaroxaban in Patients with Heart Failure, Sinus Rhythm, and Coronary Disease

COMMANDER HF Trial Summary: Zannand F et al. randomized 5,022 patients with coronary arte

TRED-HF Trial (2019): Withdrawal of treatment for HF in patients with recovered DCM

TRED-HF Trial Summary: Halliday et al. randomized 51 patients with dilated cardiomyopa

DECLARE TIMI 58 Trial (2019): Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes

DECLARE TIMI 58 Trial Summary: Wiviott et al. randomized 17,160 patients with DMII (HbA1c

OPTIC Trial (2019): Omadacycline for Community-Acquired Bacterial Pneumonia

OPTIC Trial Summary: Stets et al. randomized 774 patients with community-ac

MOMENTUM 3 Trial (2018): Magnetically Levitated Cardiac Pump in Heart Failure

MOMENTUM 3 Trial Summary: Mehra et al. randomized 366 patients with advanced HF (NYHA clas

TRICC Trial (1999): Transfusion requirements in critical care

TRICC trial Summary: Hebert PC et al. randomized 838 critically ill patients with anemia H

TNT Trial (2005): Intensive lipid lowering with atorvastatin in patients with Stable CAD

TNT Trial Summary: LaRosa et al. randomized 10,001 patients with CAD defined by prior MI,

Transfusion Strategies for Acute Upper Gastrointestinal Bleeding Trial (2013)

In 2013, Dr. Villanueva et al. randomly assigned over 921 patients with upper gastrointest

RE-DUAL PCI Trial (2017): Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation

RE-DUAL PCI Trial Summary RE-DUAL PCI trial was a multi-center, randomized trial that

WOEST Trial (2013): Clopidogrel with or without aspirin in patients taking OAC and undergoing PCI

WOEST Trial Summary WOEST trial was an open-label randomized controlled trial in patients

AF-CHF Trial (2008): Rhythm Control versus Rate Control for Atrial Fibrillation and Heart Failure

  AF-CHF Trial Summary: Roy D et al. randomized 1,376 patients with nonvalvular atria

SPRINT MIND Trial (2019): Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia

SPRINT-MIND Trial Summary: Authors of this trial randomized 9,361 adults aged 50 years or

HERCULES Trial (2019): Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura

Source: NEJM

TITAN Trial (2016): Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura

Source: NEJM

FAME 2 Trial (2012): FFR-Guided PCI vs Medical Therapy in Stable CAD

Source: NEJM

FAME Trial (2009): FFR vs Angiography for Guiding PCI

Source: NEJM

IDNT Trial (2001): Irbesartan in diabetic nephropathy

Source: NEJM

LEADER Trial (2016): Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes

Source: NEJM

PReVENT Trial (2018): Low vs Intermediate Tidal Volume Strategy in ICU Patients

Source: JAMA

CRISTAL Trial (2013): Fluid Resuscitation with Colloids vs. Crystalloids in Hypovolemic Shock

Source: JAMA

MADIT-II (2002): Prophylactic ICD in Patients with Myocardial Infarction and Reduced Ejection Fraction

Source: NEJM

IMPROVE IT (2015): Ezetimibe + statin in acute coronary syndrome (ACS)

Source: NEJM

RAVE Trial (2010): Rituximab versus cyclophosphamide for ANCA-associated vasculitis

Source: NEJM

PROVE IT Trial (2004): Intensive vs Moderate Lipid Lowering with Statins after ACS

PROVE IT Trial Summary In 2004, Dr. Cannon et al. randomly assigned over 4,162 patients wi

TRAPS Trial (2018): Rivaroxaban vs. warfarin in antiphospholipid syndrome

Source: Blood

FREGAT Trial (2019): Minimally Invasive Esophagectomy for Esophageal Cancer

Source: NEJM FREGAT Trial Key Points Minimally invasive esophagectomy (MIE) was found t

Algorithm: Diagnostic Workup of Primary Aldosteronism

Primary Aldosteronism Diagnosis Algorithm Primary aldosteronism is characterized by elevat

SMART-DATE Trial (2018): 6 vs 12 months of DAPT after PCI with DES in ACS

The SMART-DATE trial tested the hypothesis as to whether 6 months of dual antiplatelet the

MIRACL Trial (2001): Atorvastatin use for early recurrent ischemic events in ACS

2001, Effects of atorvastatin on early recurrent ischemic events in acute coronary syndrom

VANISH Trial (2016): VT Ablation vs Escalation of Antiarrhytmic drugs

2016, VANISH Trial – Ventricular Tachycardia Ablation versus Escalation of Antiarrhy

CANTOS Trial (2017): Canakinumab for Atherosclerotic Disease

2017, CANTOS Trial: Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease,

FOURIER Trial (2017): Evolocumab and Clinical Outcomes in Patients with CVD

FOURIER Trial Key Points: FOURIER trial established the role of PCSK9 inihibitor therap

STOP-IT Trial (2015): Short Course of Antibiotics for Intraabdominal Infections

2015, Short-Course Antimicrobial Therapy for Intraabdominal Infection, NEJM STOP-IT Trial

FRISC II Trial (2006): Invasive vs non-invasive treatment in unstable CAD

1999, Invasive compared with non-invasive treatment in unstable coronary-artery disease, T

RENAL Trial (2009): Intensity of CRRT in Critically Ill Patients

2009, Intensity of Continuous Renal-Replacement Therapy in Critically Ill Patients (RENAL)

TIMACS Trial (2009): Early versus Delayed Invasive Intervention in ACS

2009, TIMACS trial: Early vs delayed invasive intervention in acute coronary syndrome, NEJ

IABP-SHOCK II Trial (2012): Intraaortic Balloon Support for Myocardial Infarction with Cardiogenic Shock

2012, Intraaortic Balloon Support for Myocardial Infarction with Cardiogenic Shock, NEJM

RESPECT Trial (2013): Closure of PFO versus Medical Therapy after Cryptogenic Stroke

2013, Closure of Patent Foramen Ovale versus Medical Therapy after Cryptogenic Stroke, NEJ

ACCORD Trial (2008): Effects of Intensive Glucose Lowering in Type 2 Diabetes

ACCORD Trial Summary: Gerstein et al randomized 10,251 patients with type 2 diabetes melli

PACIFIC Trial (2017): Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC

PACIFIC Trial Summary (NEJM 2018): Scott J et al. randomized 713 patients with stage III u

DEFUSE-3 Trial (2018): Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging

DEFUSE-3 Trial Summary: Gregory W et al. randomized 182 patients with proximal middle-cere

SURVIVE Trial (2007): Levosimendan vs dobutamine for patients with acute decompensated heart failure

2007, Levosimendan in acute decompensated heart failure, JAMA

ATHOS-3: Angiotensin II for the Treatment of Vasodilatory Shock

ATHOS-3 Trial Summary: A total of 321 patients with vasodila

ULTIMATE Trial: IVUS vs Angiography-Guided Implantation of DES

ULTIMATE Trial Key Points: At 12 months, patients undergoing IVUS guided PCI had lower

AVERT Trial: Apixaban to Prevent VTE in Patients with Cancer

2018, Apixaban to Prevent Venous Thromboembolism in Patients with Cancer, NEJM The AVERT

BLOCK HF: Biventricular versus Right Ventricular Pacing in Heart Failure Patients with AV Block

  2013, Biventricular versus Right Ventricular Pacing in Heart Failure Patients with

EXCEL: Everolimus-Eluting Stents or Bypass Surgery for Left Main CAD

2016, Everolimus-Eluting Stents or Bypass Surgery for Left Main Coronary Artery Disease, N

LIPID: Pravastatin in patients with coronary heart disease

1998, Pravastatin in patients with coronary heart disease, NEJM

MOPETT: Low-dose tPA for submassive PE

2013, Low-dose tPA for submassive PE, AJC

EINSTEIN PE: Rivaroxaban for Acute PE

2012, Rivaroxaban for Acute Pulmonary embolism, NEJM

COLONPREV: FIT vs. colonoscopy for colon cancer screening

2012, FIT vs. colonoscopy for colon cancer screening, NEJM

WAKE-UP: MRI guided thrombolysis with alteplase in stroke

2018, MRI guided thrombolysis with alteplase in stroke with unknown time of onset, NEJM

EXTEND-IA TNK: Tenecteplase vs Alteplase in Ischemic Stroke

2018, Tenecteplase vs Alteplase in Ischemic Stroke, NEJM

SOCRATES: Ticagrelor versus aspirin in acute stroke or TIA

2016, Ticagrelor versus aspirin in acute stroke or TIA, NEJM

SPARCL: High-dose atorvastatin after stroke or TIA

2006, High-dose atorvastatin after stroke or transient ischemic attack (TIA), NEJM

ADRENAL: Glucocorticoids in Septic Shock

2018, Glucocorticoids in Septic Shock, NEJM

PROWESS-SHOCK: Activated protein C (DrotAA) in Sepsis

2012, Activated protein C (DrotAA) in Sepsis, NEJM

PRORATA: Procalcitonin guided antibiotic therapy in critically ill patients

2010, Procalcitonin guided antibiotic therapy in critically ill patients, The Lancet

PIONEER-HF: Angiotensin-neprilysin inhibition in acute decompensated heart failure

2018, Angiotensin-neprilysin inhibition in acute decompensated heart failure, NEJM

Ancillary DIG: Digoxin in HFpEF

2006, Digoxin in Heart failure with preserved ejection fraction, Circulation

DIG: Digoxin in HFrEF

1997, Digoxin in Heart failure with reduced ejection fraction, NEJM

EMPA-REG OUTCOMES: Empagliflozin, CV, and Mortality in Type 2 Diabetes

2015, Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes, NEJM

REDUCE-IT: CV risk reduction with Icosapent ethyl for hypertriglyceridemia

2018, Cardiovascular risk reduction with Icosapent ethyl for hypertriglyceridemia, NEJM

VITAL: N3 fatty acid supplements for prevention of CVD and cancer

2018, N3 fatty acid supplements for prevention of CVD and cancer, NEJM

VITAL: Vitamin D3 for prevention of CVD and cancer

2018, Vitamin D3 for prevention of CVD and cancer, NEJM

DAPT: 12 or 30 months of DAPT after DES-PCI

2014, 12 or 30 months of dual antiplatelet therapy after drug-eluting stents PCI, NEJM

FREEDOM: PCI vs CABG in Patients with Diabetes and multivessel CAD

2012, Percutaneous Coronary Intervention (PCI) vs CABG in Patients with Diabetes and multi

CASTLE-AF: Catheter Ablation for Atrial Fibrillation with Heart Failure

2018, Catheter Ablation for AF with Heart Failure, NEJM

ARISTOTLE: Apixaban vs. warfarin in atrial fibrillation

2011, Apixaban vs. warfarin in atrial fibrillation, NEJM

ROCKET-AF: Rivaroxaban vs. warfarin in atrial fibrillation

2011, Rivaroxaban vs. warfarin in atrial fibrillation, NEJM

ART: Lung Recruitment and Titrated PEEP vs Low PEEP in ARDS

2017, Lung Recruitment and Titrated PEEP vs Low PEEP in ARDS, JAMA

PROSEVA: Prone Positioning in Severe Acute Respiratory Distress Syndrome

2013, Prone Positioning in ARDS, NEJM

PARTNER A: Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients

2011, TAVR vs SAVR in High-Risk Patients, NEJM

CULPRIT-SHOCK: Culprit lesion vs multivessel PCI in ACS with cardiogenic shock

2018, Culprit lesion vs multivessel PCI in ACS with cardiogenic shock, NEJM

ESSENCE: Enoxaparin vs Unfractionated Heparin for UA/NSTEMI

1997, Enoxaparin vs Unfractionated Heparin for UA/NSTEMI, NEJM

SUP-ICU: PPI prophylaxis in ICU patients at risk of GI bleed

2018, Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU, NEJM

CAPSTONE-1: Baloxavir Marboxil for Uncomplicated Influenza

2018, Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents, NEJM

BICAR-ICU: Sodium Bicarbonate in Severe Metabolic Acidaemia

  2018, Sodium bicarbonate therapy for patients with severe metabolic acidaemia in t

FLAME: LABA + LAMA vs LABA + ICS for COPD

  2016, Indacaterol-Glycopyrronium versus Salmeterol-Fluticasone for COPD, NEJM

AGE: Mammographic screening from age 40 years

  2006, Effect of mammographic screening from age 40 years on breast cancer mortalit

IDEAL: Early versus Late Dialysis in Patients with ESRD

  2010, Does early initiation of dialysis in CKD improves survival, NEJM

EPHESUS: Eplerenone in patients with LV dysfunction after MI

2003, Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysf

CURE: Effects of Clopidogrel plus Aspirin in Patients with NSTEMI

2001, Effects of Clopidogrel in Addition to Aspirin in Patients with Acute Coronary Syndr

CAST I: Use of Antiarrhythmics post-MI for Cardiac Arrhythmia Suppression

1991, Mortality and morbidity in patients receiving encainide, flecainide, or placebo, NE

CHARISMA: Aspirin/clopidogrel vs. aspirin for CV prevention

2006, Clopidogrel and aspirin versus aspirin alone for prevention of atherothrombosis, NE

CHAMPION PHOENIX: Cangrelor in PCI

2013, Effect of Platelet Inhibition with Cangrelor during PCI on Ischemic Events, NEJ

ASCEND: Effects of n−3 Fatty Acid Supplements in Diabetes Mellitus

2018, N3 fatty acid supplements for primary prevention in DM2, NEJM

ASCEND: Aspirin for primary prevention in patients with Diabetes

2018, Aspirin for primary prevention in patients with Diabetes mellitus, NEJM

LESS: Epidural Glucocorticoid Injections for Spinal Stenosis

  2014, epidural glucocorticoid + lidocaine vs lidocaine only injections for spinal

POISE: Metoprolol succinate in patients undergoing non-cardiac surgery

    2008, Extended-release metoprolol succinate in patients undergoing non-cardi

SALT-ED: Balanced crystalloids versus saline in non-critically ill adults

2018, Lactated Ringer’s or Plasma-Lyte vs normal saline in non-critically ill patie

COMET: Comparison of Carvedilol and Metoprolol in Chronic Heart Failure

2003, Carvedilol vs Metoprolol in Heart Failure, The Lancet The COMET trial randomized 302

POP-UP: Pantoprazole or Placebo for Stress Ulcer Prophylaxis

2016, Pantoprazole for reducing GI bleeding in intubated patients, Critical Care Medicine

RACE II: Strict vs Lenient Control of Heart Rate in Atrial Fibrillation

  2010, Heart Rate Control in patients with Atrial Fibrillation in Preventing CV even

METEOR: Surgery vs Physical Therapy for a Meniscal Tear and Osteoarthritis

2013, Surgery vs Physical Therapy for a Meniscal Tear and Osteoarthritis, NEJM

HOPE: ACE inhibitors, ramipril in high risk CV patients

2000, Effect of ACE inhibitors, ramipril on cardiovascular morbidity and mortality, NEJM H

CRYSTAL-AF: Cryptogenic Stroke and Underlying Atrial Fibrillation

2014, 30 Days AF monitoring in patients with Cryptogenic Stroke, NEJM CRYSTAL AF Trial Sum

SYNTAX: PCI vs CABG in Severe CAD

  2009, Percutaneous Coronary Intervention versus CABG for Severe Coronary Artery Di

CHOIR: Correction of Anemia with Epoetin Alfa in Chronic Kidney Disease

2006, CHOIR trial: anemia correction in patients with CKD, NEJM

HACA: Hypothermia in Cardiac Arrest

2002, Mild Therapeutic Hypothermia to Improve the Neurologic Outcome after Cardiac Arrest

REDUCE: Short-term vs Conventional Glucocorticoid Therapy in Acute Exacerbations of COPD

    2013, 5 days vs 14 days Glucocorticoid Therapy in Acute Exacerbations of CO

COURAGE: PCI vs Medical Therapy in Stable CAD

2007, PCI + medical therapy vs medical therapy only in stable coronary artery disease, NEJ

NELSON: CT Screening For Lung Cancer in High Risk Population

  Full trial results to follow the publication. This abstract format was presented at

Albumin in Spontaneous Bacterial Peritonitis

1999, Effect of IV Albumin on Renal Impairment in Patients with Cirrhosis and SBP, NEJM

COAPT Trial: Mitral Valve Repair in Heart Failure Patients with Functional Mitral Regurgitation

2018, Transcatheter mitral valve repair in patients with Heart failure, NEJM, ACC COAPT Tr

COMMIT Trial: Metoprolol in Acute Myocardial Infarction

2005, Early intravenous then oral metoprolol after acute MI, The LANCET

ARRIVE Trial: Aspirin for Primary Prevention in Adults at Moderate Cardiovascular Risk

  2018, Effect of Aspirin in elderly at moderate CVD risk | LANCET

ASPREE Trial: Aspirin for Primary Prevention in Healthy Adults

2018, Effect of Aspirin on CV Events and Bleeding in the Healthy Elderly | NEJM

Fidaxomicin in C. difficile Diarrhea

2011, Fidaxomicin versus vancomycin for Clostridium difficile infection | NEJM

MERINO Trial: Piperacillin-Tazobactam vs Meropenem in ESBL infections

MERINO Trial: 2018, Pip-Tazo vs Meropenem in patients with E-coli or Klebsiella infection

POET Trial: IV vs PO Antibiotics in Left Heart Endocarditis

2018, POET Trial: Partial Oral vs Intravenous Antibiotic Treatment of Endocarditis | NEJM

SCOT-HEART Trial: Coronary CT Angiography and Risk of Myocardial Infarction

2018, CTA vs standard care in preventing MI, SCOT-HEART Visual Abstract | NEJM

CREST Trial: Stenting versus CEA for Treatment of Carotid-Artery Stenosis

2010, Carotid artery stenting vs carotid endarterectomy visual abstract, NEJM

VALENCE Trial: Sofosbuvir and ribavirin in HCV genotypes 2 and 3

  2014, Sofosbuvir + ribavirin for HCV, NEJM

AFFIRM Trial: Rate control vs Rhythm control in Atrial Fibrillation

2002, Rate-control and Rhythm-Control in Patients in patients with AF, NEJM

SOME Trial: Screening for Occult Cancer in Unprovoked Venous Thromboembolism

  2015, Cancer screening in unprovoked venous thromboembolism, NEJM

Rifaximin and Lactulose for HE trial

  2013, Rifaximin plus Lactulose in Treatment of Hepatic Encephalopathy, The America

RABBIT 2 Trial: Basal-bolus insulin in inpatients with DM

2007, Basal insulin for DM2, Diabetes Care

Safety of Discharging Patients Directly Home From the ICU

2018, Discharging from ICU vs from medicine wards, JAMA Internal Medicine

SADHART Trial: Sertraline Use in Depression after ACS

2002, Safety of Sertraline after ACS, JAMA

BeSt trial: DMARD ± prednisone or infliximab in RA

2005, BeSt trial Visual Abstract: DMARD ± prednisone or infliximab in RA, Arthritis Rh

MANAGE Trial: Dabigatran in myocardial injury after non-cardiac surgery

2018, MANAGE Trial Visual Abstract: Dabigatran in myocardial injury surgery, Lancet

SPYRAL HTN-ON MED Trial: Renal Denervation in Uncontrolled Hypertension

The SPYRAL HTN-ON MED trial was a large multicenter global scale trial that compared the

ATLAS ACS-2: Rivaroxaban after ACS

The ATLAS ACS-2 trial tested the use of rivaroxaban in addition to standard dual antiplate

TRISS Trial: Restrictive vs Liberal Transfusion in Septic Shock

The TRISS trial studied the role of transfusion thresholds in septic shock. 998 patients w

ALBIOS Trial: Albumin in Severe Sepsis & Septic Shock

2014, Does albumin infusion helps in Septic shock?, NEJM

PARAMEDIC2 Trial: Epinephrine in Out-of-Hospital Cardiac Arrest

The PARAMEDIC2 trial that was recently published in NEJM studied the use of epinephrine in

COMPASS Trial: Rivaroxaban plus aspirin in stable cardiovascular disease

Does adding rivaroxaban to aspirin therapy in patients with stable cardiovascular disease

PAMPer Trial: Prehospital Plasma in Trauma Patients

PAMPer trial is a multicenter randomized trial that evaluated the use of thawed plasma in

ACT Trial: Acetylcysteine in patients undergoing Angiography

ACT trial was the initial large sized randomized controlled trial that was initiated to te

EXTRA Trial: Omalizumab in Severe Allergic Asthma Visual Abstract

Omalizumab is an anti-IgE monoclonal antibody that was coined to prevent asthma exacerbati

Bezafibrate in Primary Biliary Cholangitis

A Placebo-controlled Trial of Bezafibrate in Primary Biliary Cholangitis Trial Summarized

Basic Modes of Mechanical Ventilation Infographic

Mechanical ventilation is a complex topic to understand. With this infographic, I have tri

ANGIE02 Trial: Closed-Loop Insulin Delivery for Type II Diabetes Mellitus Trial Visual Absract

Closed-Loop Insulin Delivery for Glycemic Control in Noncritical Care Summarized by: Tabin

Algorithm for Management of Adult Patients with DKA

Diabetic ketoacidosis requires emergent intervention and treatment. The treatment of DKA r

TOPCAT trial: Spironolactone in HFpEF

Spironolactone is a well known survival improvement agent for heart failure with reduced e

Abdominal Aortic Aneurysm Screening USPSTF 2014 Guidelines

The current USPSTF guidelines for screening of abdominal aortic aneurysm were published in

WARFASA Trial: Aspirin for preventing VTE Recurrence

Summarized by / Author: Usama bin Nasir, MD Contribution To Literature: WARFASA trial

DAWN Trial: Mechanical Thrombectomy 6 to 24 Hours after Stroke

The DAWN trial was a major success when it comes to mechanical thromebectomy eligibility t

AMPLIFY Trial: Oral apixaban for VTE

Use of novel oral anticoagulation agents for VTE was established after a series of non-inf

PROTECT AF Trial: Closure of the LAA versus warfarin therapy in patients with Atrial Fibrillation

We currently lack significant data or clear cut guidelines for closing left atrial appenda

USPSTF/ACC/AHA guidelines for Statin Use for the Primary Prevention of Cardiovascular Disease in Adults

The USPSTF and ACC/AHA guidelines for statin use in adults aged 40-75 years are consistent

Association of Metformin Use With Risk of Lactic Acidosis Across the Range of Kidney Function

Visual Abstract: Metformin use based on kidney function. Over ~1 million patients are not

Risks of concomitant aspirin therapy with oral anticoagulation in patients with atrial fibrillation

Summarized by: Usama bin Nasir, MD Contribution To Literature: Atrial fibrillation (A

Radial-Artery or Saphenous-Vein Grafts in CABG

Current ACC/AHA guidelines recommend (IIb) radial artery grafting for >70% LAD stenosis

Tenofovir versus Placebo to Prevent Perinatal Transmission of Hepatitis B

Summarized by / Author: Rooma Nankani MD (1), Rohini Manaktala MD (1) Summary Reviewer:

Helicobacter Pylori Treatment for the Prevention of Metachronous Gastric Cancer

Summarized by / Author: Rohini Manaktala MD (1), Rooma Nankani MD (1) Summary Reviewe

ProACT Trial: Procalcitonin-Guided Antibiotics for Lower Respiratory Tract Infection

Procalcitonin has proven to be a great marker for guiding antibiotics treatment in patient

STOPAH Trial: Prednisolone or Pentoxifylline for Alcoholic Hepatitis

The use of steroids vs Pentoxifylline in severe alcoholic hepatitis has long been debated.

STRIVE Trial: Erenumab for Episodic Migraine

The STRIVE trial introduced Erenumab, a once monthly self injectable drug for prevention o

CABANA Trial: Catheter Ablation vs Anti-arrhythmic Drug Therapy for Atrial Fibrillation

Source: ACC

ANNEXA Trial: Andexanet Alfa for the Reversal of Factor Xa Inhibitor Activity

Source: NEJM

EAGLES Trial: Cardiovascular Safety of Varenicline, Bupropion, and Nicotine Patch in Smokers

Source: JAMA Internal Medicine

TTM Trial: Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest

Source: NEJM

Tenecteplase versus Alteplase for Ischemic Stroke

Source: NEJM

IMPACT Trial: Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD

Source: NEJM

Relationship between Clinic and Ambulatory Blood-Pressure Measurements and Mortality

Source: NEJM

Undetectable High-Sensitivity Cardiac Troponin T Level in the Emergency Department and Risk of Myocardial Infarction

Source: JACC

SMART Trial: Balanced Crystalloids versus Saline in Critically Ill Adults

Source: NEJM

AKIKI Trial: Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit

Source: NEJM

STAR Trial: Effects of Tamoxifen vs Raloxifene on the Risk of Developing Invasive Breast Cancer and Other Disease Outcomes

Source: JAMA

PRESERVE Trial: Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine

Study Question: Does the use of sodium bicarbonate or acetylcysteine affect outcomes after

Association Between Cirrhosis and Stroke in a Nationally Representative Cohort

Contribution by Leon Averbukh, Internal Medicine UConn Health Source: JAMA Neurology

STAMPEDE Trial: Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes

Source: NEJM

PEITHO Trial: Fibrinolysis for patients with intermediate-risk pulmonary embolism

Source: NEJM

PRECISION Trial: Cardiovascular safety of celecoxib, naproxen, or ibuprofen for arthritis

This visual abstract represents the important findings of the PRECISION trial. The trial c

MASS trial: Screening men for abdominal aortic aneurysm: 10 year mortality and cost effectiveness

Source: BMJ

MODIFY I / II Trials: Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection

Source: NEJM

ICON-RELOADED Study: N-Terminal Pro–B-Type Natriuretic Peptide in the Emergency Department

Source: JACC

PROPPR Trial: Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs 1:1:2 Ratio and Mortality in Patients With Severe Trauma

Source: JAMA Contribution by Sagar Dave PGY2, Emergency Medicine UConn Health

PREPIC 2 Trial: Effect of a Retrievable IVC Filter Plus Anticoagulation vs Anticoagulation Alone on Risk of Recurrent Pulmonary Embolism

Source: JAMA

PROMISE Trial: Outcomes of Anatomical versus Functional Testing for Coronary Artery Disease

Source: NEJM

ADJUST-PE study: Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism

Source: JAMA

CANVAS Trial: Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes

Source: NEJM

A Cluster-Randomized Trial of Blood-Pressure Reduction in Black Barbershops

Source: NEJM

APROCCHSS Trial: Hydrocortisone plus Fludrocortisone for Adults with Septic Shock

The APROCCHSS trial clinically analyze the combination of steroid therapy in patients with

Hokusai VTE Cancer Trial: Edoxaban for Cancer-Associated VTE

Let’s talk methodology… In this randomized, open-label, non-inferiority trial, the aut

Intermittent vs Continuous Proton Pump Inhibitor Therapy for High-Risk Bleeding Ulcers

Source: JAMA Internal Medicine

VEST Trial: Vest Prevention of Early Death Trial

Source: ACC 2018

STEP Trial: Adjunct prednisone therapy for patients with community-acquired pneumonia

Source: The LANCET

IRIS trial: Imatinib Compared with Interferon and Low-Dose Cytarabine for Newly Diagnosed Chronic-Phase CML

Source: NEJM

FAMOUS Trial: Famotidine for the prevention of peptic ulcers and esophagitis in patients taking low-dose aspirin

A non-stop pharmaceutical battle… FAMOUS trial is a Phase III, randomized, double blind,

ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes with Alirocumab after an ACS

2018, Alirocumab after Acute Coronary Syndrome, ACC ODYSSEY Outcomes Trial Summary ODYSSEY

Association Between Overnight Extubations and Outcomes in the Intensive Care Unit

Source: JAMA Internal Medicine

SPACE Trial: Effect of Opioid vs Nonopioid Medications on Pain-Related Function

Source: JAMA

DOSE Trial: Diuretic Strategies in Patients with Acute Decompensated Heart Failure

Source: NEJM

JUPITER Trial: Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

Source: NEJM

ALLHAT Trial: Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs Diuretic

Source: JAMA  

PARADIGM-HF Trial: Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure

2014, Sacubitril-valsartan vs Enalapril in HF, NEJM. PARADIGM-HF Trial Summary The PARADIG

Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock

  Source: CHEST

RENAAL Trial: Losartan in Patients with Type 2 Diabetes and Nephropathy

Source: NEJM RENAAL Trial Key Points1. Losartan was found to have significant reno-protec

SPRINT Trial: Intensive versus Standard Blood Pressure Control

The SPRINT trial study was an important leap towards tighter blood pressure control in pat

NICE-SUGAR Trial: Intensive Glucose Control in Critically Ill Patients

NICE-SUGAR Trial: 2009, Intensive versus Conventional Glucose Control in Critically Ill Pa