2006, CHOIR trial: anemia correction in patients with CKD, NEJM
The SPYRAL HTN-ON MED trial was a large multicenter global scale trial that compared the effect of renal denervation + antihypertensive medications with antihypertensive medications alone. The results were significantly in favor of renal denervation in patients who had uncontrolled hypertension noticed in the clinic settings. Check out the visual abstract and following text for the..
ACT trial was the initial large sized randomized controlled trial that was initiated to test the role of acetylcysteine in protecting kidneys from contrast. More than 2000 patients were enrolled in this placebo-controlled trial. The results failed to establish any renal protective role of acetylcysteine in patients undergoing coronary or peripheral angiography. Source
Source: NEJM RENAAL Trial Key Points1. Losartan was found to have significant reno-protective role in patients with type II diabetes and nephropathy.2. Losartan did not affect mortality in this patient population.3. Proteinuria significant improved in patients taking losartan compared to placebo.4. The IDNT trial tested irbesartan and reported similar renoprotective role in diabetic nephropathy. Guideline Recommendations based on RENAAL Trial: The..