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VALIANT Trial Summary: Pfeffer et al. randomized 14,703 patients with acute MI within prior 10 days complicated by HF and/or LVEF ≤35% to either valsartan or captopril or combination of both. The objective was to assess the efficacy of ARBs compared with ACE-I in patients in the post-MI period complicated by HF and/or LV systolic dysfunction. The results of the trial showed similar mortality rates among both ACE and ARB groups along with similar rates in combination of both. The authors of the VALIANT trial concluded that Valsartan was as effective as captopril in improving survival among patients with HF and/or LV dysfunction in the post-MI period.
MADIT-II (2002): Prophylactic ICD in Patients with Myocardial Infarction and Reduced Ejection Fraction
2018, Culprit lesion vs multivessel PCI in ACS with cardiogenic shock, NEJM
2003, Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction, NEJM
1991, Mortality and morbidity in patients receiving encainide, flecainide, or placebo, NEJM
2006, Clopidogrel and aspirin versus aspirin alone for prevention of atherothrombosis, NEJM
2005, Early intravenous then oral metoprolol after acute MI, The LANCET
2018, CTA vs standard care in preventing MI, SCOT-HEART Visual Abstract | NEJM
Undetectable High-Sensitivity Cardiac Troponin T Level in the Emergency Department and Risk of Myocardial Infarction