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VALIANT Trial (2003): Valsartan, Captopril, or Both in Myocardial Infarction

VALIANT Trial Summary visual abstract

VALIANT Trial Summary: Pfeffer et al. randomized 14,703 patients with acute MI within prior 10 days complicated by HF and/or LVEF ≤35% to either valsartan or captopril or combination of both. The objective was to assess the efficacy of ARBs compared with ACE-I in patients in the post-MI period complicated by HF and/or LV systolic dysfunction. The results of the trial showed similar mortality rates among both ACE and ARB groups along with similar rates in combination of both.  The authors of the VALIANT trial concluded that Valsartan was as effective as captopril in improving survival among patients with HF and/or LV dysfunction in the post-MI period.

Source: NEJM

MADIT-II (2002): Prophylactic ICD in Patients with Myocardial Infarction and Reduced Ejection Fraction

Source: NEJM

CULPRIT-SHOCK: Culprit lesion vs multivessel PCI in ACS with cardiogenic shock

2018, Culprit lesion vs multivessel PCI in ACS with cardiogenic shock, NEJM

EPHESUS: Eplerenone in patients with LV dysfunction after MI

2003, Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction, NEJM

CAST I: Use of Antiarrhythmics post-MI for Cardiac Arrhythmia Suppression

1991, Mortality and morbidity in patients receiving encainide, flecainide, or placebo, NEJM

CHARISMA: Aspirin/clopidogrel vs. aspirin for CV prevention

2006, Clopidogrel and aspirin versus aspirin alone for prevention of atherothrombosis, NEJM

COMMIT Trial: Metoprolol in Acute Myocardial Infarction

2005, Early intravenous then oral metoprolol after acute MI, The LANCET

SCOT-HEART Trial: Coronary CT Angiography and Risk of Myocardial Infarction

2018, CTA vs standard care in preventing MI, SCOT-HEART Visual Abstract | NEJM

Undetectable High-Sensitivity Cardiac Troponin T Level in the Emergency Department and Risk of Myocardial Infarction

Source: JACC

VEST Trial: Vest Prevention of Early Death Trial

Source: ACC 2018

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