Pulmonary Medicine
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MARCH Trial: Carbocisteine and Hypertonic Saline in Acute Respiratory Failure
Patients receiving invasive mechanical ventilation frequently develop thick or difficult-to-clear respiratory secretions. Mucolytic agents such as carbocisteine and nebulized hypertonic saline are commonly considered to improve secretion clearance, but high-quality evidence supporting their routine use in critically ill ventilated patients has been limited. The MARCH trial, published in the New England Journal of Medicine in…
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ADVANCE OUTCOMES Trial: Ralinepag Reduces Clinical Worsening in Pulmonary Arterial Hypertension
A new phase 3 trial published in The Lancet suggests that ralinepag, an oral once-daily selective prostacyclin IP receptor agonist, can substantially reduce the risk of clinical worsening in patients with pulmonary arterial hypertension (PAH) already receiving contemporary background therapy. The ADVANCE OUTCOMES trial evaluated whether adding ralinepag to existing PAH treatment could improve long-term…