Nephrology
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Hypoaldosteronism: Clinical Cheat Sheet
What is hypoaldosteronism? Hypoaldosteronism is a condition in which aldosterone production or aldosterone effect is reduced. Aldosterone normally acts at the distal nephron to promote sodium reabsorption and potassium and hydrogen ion secretion. When aldosterone is deficient or ineffective, patients can develop hyperkalemia and a mild normal-anion-gap metabolic acidosis, often described as type 4 renal…
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Hyponatremia: Clinical Algorithm for Diagnosis and Treatment
Hyponatremia is usually defined as a serum sodium concentration below 135 mEq/L and is one of the most common electrolyte abnormalities encountered in clinical practice. The key concept is that hyponatremia usually reflects excess water relative to sodium, not simply a “sodium deficiency.” The danger is not just the number itself, but the speed of…
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MAJESTY Trial: Obinutuzumab vs Tacrolimus in Primary Membranous Nephropathy
Primary membranous nephropathy is an immune-mediated glomerular disease and a major cause of nephrotic syndrome in adults. Treatment often aims to reduce proteinuria, preserve kidney function, and achieve durable remission while minimizing drug toxicity. Calcineurin inhibitors such as tacrolimus can reduce proteinuria, but relapse and long-term kidney safety remain important concerns. The MAJESTY Trial evaluated…