Nephrology
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MAJESTY Trial: Obinutuzumab vs Tacrolimus in Primary Membranous Nephropathy
Primary membranous nephropathy is an immune-mediated glomerular disease and a major cause of nephrotic syndrome in adults. Treatment often aims to reduce proteinuria, preserve kidney function, and achieve durable remission while minimizing drug toxicity. Calcineurin inhibitors such as tacrolimus can reduce proteinuria, but relapse and long-term kidney safety remain important concerns. The MAJESTY Trial evaluated…