Category: Infectious Disease

HYPRESS Trial (2016): Effect of Hydrocortisone on Development of Shock Among Patients With Severe Sepsis

HYPRESS Trial Summary: Keh D, et al. randomized 380 patients with sepsis defined by ≥2 SIRS criteria, proven infection, and ≥1 organ with new dysfunction to either IV hydrocortisone or placebo. The objective was to assess if early hydrocortisone therapy reduces progression to septic shock compared to placebo in patients with severe sepsis. The results..

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Project CLEAR Trial (2019): Decolonization to Reduce Postdischarge Infection Risk among MRSA Carriers

Project CLEAR trial summary: Huang et al. randomized 2,141 patients colonized with MRSA to hygiene education or hygiene education + decontamination. Decolonization involved chlorhexidine mouthwash, baths or showers with chlorhexidine, and nasal mupirocin for 5 days twice per month for 6 months. The primary objective was to assess the efficacy of postdischarge hygiene education, as..

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PLACIDE Trial (2013): Lactobacilli and bifidobacteria in preventing antibiotic-associated and C.diff diarrhea

PLACIDE trial summary: Allen SJ et al. conducted a multicenter, randomized, double blind, placebo-controlled trial to assess the efficacy of probiotics in preventing antiobiotics associated (AAD) or C.diff associated diarrhea (CDAD) in elderly hospitalized patients. Over 2,941 elderly patients with age >65 and exposure to antibiotics were enrolled and randomized to either a probiotic therapy or placebo therapy. The primary outcome..

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OPTIC Trial (2019): Omadacycline for Community-Acquired Bacterial Pneumonia

OPTIC Trial Summary: Stets et al. randomized 774 patients with community-acquired bacterial pneumonia (PSI risk class II, III, or IV) diagnosed clinically and with imaging to either omadacycline IV or moxifloxacin IV. The objective was to assess the role of omadacycline, a new tetracycline drug in the treatment of community-acquired bacterial pneumonia. The results showed similar early clinical..

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STOP-IT Trial (2015): Short Course of Antibiotics for Intraabdominal Infections

2015, Short-Course Antimicrobial Therapy for Intraabdominal Infection, NEJM STOP-IT Trial Key Points: A shorter course (3-5 days) of antibiotics was found to be non-inferior when compared to traditional course of 4 to 7 or 7 to 14 days. Important point was to adequately control the source which means draining the abscess in case there is one or any..

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