Visualmed: Landmark Clinical Trials in Medicine

2021

ADAPTABLE
2021, High vs. Low Dose Aspirin in Cardiovascular Disease

AKIKI 2
2021, Comparison of two delayed strategies for renal replacement therapy (RRT) initiation for severe acute kidney injury (AKI)

AMPLITUDE-O
2021, Cardiovascular and renal outcomes with efpeglenatide in type 2 DM

ANT-005 TKA
2021, Efficacy & Safety of Abelacimab vs. enoxaparin in patients undergoing total knee arthroplasty.

ATTACC
2021, Therapeutic anticoagulation with Heparin in noncritically Ill patients with Covid-19

ATTIRE
2021, Albumin Infusions in Hospitalized Patients with Cirrhosis

Action Seniors
2021, Home-based exercise program as a fall prevention strategy among high-risk older adults after a fall

BCN-PEP-CoV2
2021, A Cluster-Randomized Trial of Hydroxychloroquine for Prevention of Covid-19

BEST-MSU
2021, Outcomes from mobile stroke units (MSU's) 4.5 hours after onset of acute stroke symptoms

BLAZE-1
2021, Bamlanivimab as Monotherapy or in Combination With Etesevimab in Covid-19

COVACTA
2021, Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia

DATIPO
2021, Antibiotic Therapy for 6 or 12 Weeks for Prosthetic Joint Infection

DHOPE-DCD
2021, Hypothermic Machine Perfusion in Liver Transplantation

DOREMI
2021, Milrinone as compared with Dobutamine in the treatment of Cardiogenic shock

EARLY-AF
2021, Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation

EMPEROR-Preserved
2021, Empagliflozin in heart failure with a preserved ejection fraction

EPIC
2021, Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19

FLOWER-MI
2021, Multivessel PCI Guided by FFR or Angiography for MI

HOT-ICU
2021, Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure

ILLUMINATE-A
2021, Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1

LAAOS III
2021, Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke

LIFE (Sacubitril/Valsartan)
2021, Sacubitril/valsartan in Advanced Heart Failure

MENDS2
2021, Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis

NAVIGATOR
2021, Tezepelumab in Severe, Uncontrolled Asthma

PIROUTTE
2021, Pirfenidone in heart failure with preserved ejection fraction (HFpEF)

Psilodep-RCT
2021, Psilocybin versus Escitalopram for Depression

RICH
2020, Effect of regional citrate vs systemic heparin anticoagulation during continuous kidney replacement therapy in AKI

Rifaximin after TIPS
2021, Use of Rifaximin in the Prevention of Overt Hepatic Encephalopathy After TIPS

SCORED
2021, Sotagliflozin in Patients with Diabetes and Chronic Kidney Disease

SOLOIST-WHF
2021, Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure

SPS3 Clopidogrel-ASA
2021, Clopidogrel +aspirin in patients with recent lacunar stroke

SSaSS
2021, Effect of salt substitution on cardiovascular events and death

STEP
2021, Trial of INTENSIVE blood-pressure control in older patients with hypertension

STEP1
2021, Once-Weekly Semaglutide in Adults with Overweight or Obesity

STOP-COVID
2021,Tofacitinib in Patients Hospitalized with Covid-19 Pneumonia

SURPASS-2
2021, Tirzepatide versus Semaglutide once weekly in patients with type 2 Diabetes

TBTC Study 31
2021, Four-Month Rifapentine Regimens with or without Moxifloxacin for Tuberculosis

TOMAHAWK
2021, Immediate vs. delayed Angiography after out-of-hospital cardiac arrest without ST-segment elevation

TTM2
2021, Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest

2020

ACTIV-3
2020, Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19

ACTS
2020, Effect of ascorbic acid, corticosteroids, and thiamine on organ injury in septic shock

ACTT-1
2020, Remdesivir for the Treatment of Covid-19

ACTT-2
2020, Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19

ALLIANCE
2020, Axillary vs no axillary dissection on 10-year overall survival in invasive breast cancer and sentinel node metastasis

Alcohol Abstinence�
2020, Alcohol Abstinence in Drinkers with Atrial Fibrillation

BACC bay
2020, Efficacy of Tocilizumab in Patients Hospitalized with Covid-19

BLISS-LN
2020, Belimumab in Lupus Nephritis

CITY
2020, Effect of continuous glucose monitoring on glycemic control in adolescents and young adults with type 1 diabetes

CODA
2020, Antibiotics vs. Appendectomy for Appendicitis

COMPARE CRUSH
2020, Effect of Pre-Hospital Crushed Prasugrel Tablets in Patients with STEMI Planned for PCI

COVE
2020, Efficacy and Safety of the mRNA-1273 (Moderna) SARS-CoV-2 Vaccine

COVID-19 PEP
2020, Hydroxychloroquine as Postexposure Prophylaxis for Covid-19

CRCPilotNorway
2020, Colorectal Cancer Screening With Repeated Fecal Immunochemical Test Versus Sigmoidoscopy

CROWN
2020, Lorlatinib or Crizotinib in Advanced ALK-Positive Lung Cancer

Caravaggio
2020, Apixaban for the Treatment of Venous Thromboembolism Associated with Cancer

CoDEX
2020, Effect of dexamethasone on days alive and ventilator-free in moderate or severe ARDS and COVID-19

DAPA-CKD
2020, Dapagliflozin in Patients with Chronic Kidney Disease

DIETFITS
2020, Low-fat vs low-carbohydrate diet on weight loss & the association with genotype pattern or insulin secretion

EAST-AFNET 4
2020, Early Rhythm-Control Therapy in Patients with Atrial Fibrillation

ELDERCARE-AF
2020, Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation

EMPACTA
2020, Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia

EMPEROR-Reduced
2020, Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure

EVAPORATE
2020, Effect of icosapent ethyl on progression of coronary atherosclerosis

EXPLORER-HCM
2020, Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy

GALACTIC-HF
2020, Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure

GRECCO-19
2020, Colchicine vs Standard Care in hospitalized COVID-19 patients

HALT-IT
2020, Effects of Tranexamic acid (TXA) on death and thromboembolic events in patients with acute GI bleeds

ICTOC
2020, Compression Therapy to Prevent Recurrent Cellulitis of the Leg

LACTIN-V
2020, Lactin-V to Prevent Recurrence of Bacterial Vaginosis

LOTUS China
2020, Lopinavir�Ritonavir in Adults Hospitalized with Severe Covid-19

NIX-TB
2020, Treatment of Highly Drug-Resistant Pulmonary Tuberculosis

OPTIMISE
2020, Antihypertensive medication reduction for short-term blood pressure control in patients ? 80 years

PARTNER B
2020, Transcatheter Aortic-Valve Implantation (TAVR/TAVI) for Aortic Stenosis in Patients Who Cannot Undergo Surgery

PERL
2020, Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes

PFIZER COVID-19
2020, Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

PIRATE
2020, C-Reactive Protein�Guided Antibiotic Treatment Duration in Gram Negative Bacteremia

POPular TAVI
2020, Anticoagulation with or without Clopidogrel after Transcatheter Aortic-Valve Implantation

POPular TAVI EU
2020, Aspirin with or without Clopidogrel after Transcatheter Aortic-Valve Implantation

PRAETORIAN
2020, Subcutaneous or Transvenous Defibrillator Therapy

PRAGUE-17
2020, LAA Closure vs DOAC in High-Risk Patients With AF

PRONOMOS
2020, Rivaroxaban or Enoxaparin in Nonmajor Orthopedic Surgery

PT vs Steroids in OA
2020, Physical Therapy versus Glucocorticoid Injection for Osteoarthritis of the Knee

PlasmAr
2020, Convalescent Plasma in Covid-19 Severe Pneumonia

RAFF2
2020, Electrical vs. Pharmacological Cardioversion for ED Patients With Acute AF

RATE-AF
2020, Effect of Digoxin vs Bisoprolol for Heart Rate Control in Atrial Fibrillation

REACH2
2020, Ruxolitinib for Glucocorticoid-Refractory Acute Graft-versus-Host Disease

REALITY
2020, Transfusion Strategies in Patients With Myocardial Infarction and Anemia

RECOVERY
2020, Dexamethasone in Hospitalized Patients with Covid-19

REGN-COV2
2020, REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19

RICH
2020, Effect of regional citrate vs systemic heparin anticoagulation during continuous kidney replacement therapy in AKI

RIVER
2020, Rivaroxaban in Patients with Atrial Fibrillation and a Bioprosthetic Mitral Valve

STARRT-AKI
2020, Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury

STOP COVID
2020, Fluvoxamine vs Placebo and clinical deterioration in outpatients with symptomatic COVID-19

STRENGTH
2020, Effect of omega-3 fatty acids vs corn oil on major adverse cardiovascular events in patients with high CV risk

THALES
2020, Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA

Tidal volumes for major surgery
2020, Effect of intraoperative Low vs conventional tidal volume on postoperative pulmonary complications in major surgery

ULTIMATE- 3 Years
2020, Intravascular Ultrasound Versus Angiography-Guided Drug-Eluting Stent Implantation: Three-year outcomes

VDKA
2020, Effect of vitamin D3 supplementation on severe asthma exacerbations in children with asthma and low vitamin D levels

VERTIS CV
2020, Cardiovascular Outcomes with Ertugliflozin in Type 2 Diabetes

VICTORIA
2020, Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction

VITAL-DEP
2020, Effects of long term Vit D3 supplementation on late life depression risk & mood symptoms

VOYAGER PAD
2020, Rivaroxaban in Peripheral Artery Disease After Revascularization

65
2020, Effect of Reduced Exposure to Vasopressors on Mortality in Critically ill Patients

2019

AFIRE
2019, Antithrombotic Therapy for Atrial Fibrillation with Stable Coronary Disease

AIMS
2019, Irbesartan in Marfan syndrome

ALCOHOL-AF
2019, Impact of Alcohol Abstinence in Moderate Drinkers With Atrial Fibrillation

ANDROMEDA-SHOCK
2019, Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on Mortality in Septic Shock

APECS
2019, Verubecestat for Prodromal Alzheimer�s Disease

ART - CABG
2019, Bilateral versus Single Internal-Thoracic-Artery Grafts at 10 Years

ASCENT-COPD
2019, Effect of Aclidinium Bromide on Major CV Events and Exacerbations in Patients With COPD

AUGUSTUS
2019, Antithrombotic Therapy or PCI in Atrial Fibrillation

Action Seniors
2021, Home-based exercise program as a fall prevention strategy among high-risk older adults after a fall

BLOCK COPD
2019, Metoprolol for the Prevention of Acute Exacerbations of COPD

CAMELLIA-TIMI 61
2019, Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients

CARMELINA
2019, Effect of linagliptin vs placebo in patients of type 2 diabetes with high cardiovascular and renal risk

CASSINI
2019, Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer

CENSER
2019. Early Use of Norepinephrine in Septic Shock Resuscitation

CITRIS-ALI
2019, Effect of Vitamin C Infusion in Patients With Sepsis and ARDS

CLASS-01
2019, Effect of laparoscopic vs open distal gastrectomy on 3-year disease-free survival in locally advanced gastric cancer

CLEAR Harmony
2019, Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol

CLEAR Wisdom
2019, Efficacy and Safety of Bempedoic Acid Added to Statins in Patients With Hypercholesterolemia and High CV Risk

COACT
2019, Coronary Angiography after Cardiac Arrest without ST-Segment Elevation

COAPT-QoL
2019, Health Status After TMVR in Patients With Heart Failure and Secondary Mitral Regurgitation

COLCOT
2019, Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction

COMPLETE
2019, Complete Revascularization with Multivessel PCI for Myocardial Infarction

CONSERVE
2019, Selective Referral Using CCTA Versus Direct Referral for Individuals Referred to Invasive Coronary Angiography for Suspected CAD

CREDENCE
2019, Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

CREOLE
2019, Comparison of Dual Therapies for Lowering Blood Pressure in Black Africans

DAHHS2
2019, Treatment of acute hepatitis C with 8 weeks of grazoprevir plus elbasvir

DAPA-HF
2019, Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction

DECISION-CTO
2019, Percutaneous Coronary Intervention for the Treatment of Chronic Total Occlusion

DECLARE-TIMI 58
2019, Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes

DEXACET
2019, Effect of Acetaminophen on postoperative delirium among older patients following cardiac surgery

EFFORT
2019, Individualised nutritional support in medical inpatients at nutritional risk

EPIC
2019, Once-Daily Plazomicin for Complicated Urinary Tract Infections

EVALUATE-HF
2019, Sacubitril-Valsartan vs Enalapril on Aortic Stiffness in Patients with HFrEF

EXCEL (5 Years)
2019, Five-Year Outcomes after PCI or CABG for Left Main Coronary Disease

EXTEND
2019, Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke

Evolut Low Risk
2019, TAVR with self-expanding valve in low risk patients

FINCH 2
2019, Effect of Filgotinib vs Placebo in patients with moderate to severe Rheumatoid Arthritis refractory to DMARDs

FMT in UC
2019, Effect of fecal microbiota transplantation on 8-week remission in patients with ulcerative colitis

FREGAT
2019, Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer

GALILEO
2019, Rivaroxaban after Transcatheter Aortic-Valve Replacement

HEALTH
2019, Total Hip Arthroplasty or Hemiarthroplasty for Hip Fracture

HERCULES
2019, Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura

HIGH-WEAN
2019, Postextubation High-Flow Nasal Oxygen + Noninvasive Ventilation vs High-Flow Nasal Oxygen Alone

HYPERION
2019, Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm

INBUILD
2019, Nintedanib in Progressive Fibrosing Interstitial Lung Diseases

INHALE
2019, Inhaled amikacin in mechanically ventilated patients with Gram-negative pneumonia

ISAR-REACT 5
2019, Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes

ISCHEMIA
2019, International Study of Comparative Health Effectiveness With Medical and Invasive Approaches

LEAP
2019, Early vs Delayed Levodopa in Parkinson�s Disease

LION
2019, Lymphadenectomy in Patients with Advanced Ovarian Neoplasms

MET-REMODEL
2019, Effect of metformin on left ventricular hypertrophy in patients with CAD without diabetes

MR-INFORM
2019, Magnetic Resonance Perfusion or Fractional Flow Reserve in Coronary Disease

MYRIAD
2019, Volatile Anesthetics versus Total Intravenous Anesthesia for Cardiac Surgery

Novel START
2019, Controlled Trial of Budesonide�Formoterol as Needed for Mild Asthma

OPTIC
2019, Omadacycline for Community-Acquired Bacterial Pneumonia

ORION-9
2019, Inclisiran for Heterozygous Familial Hypercholesterolemia

OVER
2019, Open versus Endovascular Repair of Abdominal Aortic Aneurysm

OVIVA
2019, Oral versus Intravenous Antibiotics for Bone and Joint Infection

PANSAID
2019, Paracetamol and Ibuprofen on Morphine Consumption in the Total Hip Arthroplasty

PARAGON-HF
2019, Angiotensin�Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction

PARTNER 3
2019, Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients

PAUSE
2019, Perioperative Management of Patients With Atrial Fibrillation Receiving a Direct Oral Anticoagulant

PIONEER 3
2019, Effect of Semaglutide vs sitagliptin on HbA1c in type 2 diabetes uncontrolled with metformin alone or with sulfonylurea

PIONEER 6
2019, Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes

PIVOTAL
2019, Intravenous Iron in Patients Undergoing Maintenance Hemodialysis

PREVENT
2019, Adjunctive Intermittent Pneumatic Compression for Venous Thromboprophylaxis

PreVent
2019, Bag-Mask Ventilation during Tracheal Intubation of Critically Ill Adults

Project CLEAR
2019, Decolonization to Reduce Postdischarge Infection Risk among MRSA Carriers

RACE 7 ACWAS
2019, Early or Delayed Cardioversion in Recent-Onset Atrial Fibrillation

RAPID-TnT
2019, Rapid Assessment of Possible ACS in the Emergency Department With High-Sensitivity Troponin T

RE-SPECT CVT
2019, Dabigatran Etexilate vs Dose-Adjusted Warfarin in Patients With Cerebral Venous Thrombosis

RE-SPECT ESUS
2019, Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source

RECOVERY
2019, Early Surgery or Conservative Care for Asymptomatic Aortic Stenosis

REDUCE-IT USA
2019, Reduction of Cardiovascular Events With Icosapent Ethyl in USA cohort

RELAX-AHF-2
2019, Effects of Serelaxin in Patients with Acute Heart Failure

REWIND
2019, Dulaglutide and cardiovascular outcomes in type 2 diabetes

RM-ALONE
2019, Protocol for Pacemaker and Defibrillator Surveillance Based on Remote Monitoring Only

ROSE
2019, Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome

ResPECT
2019, N95 respirators vs medical masks for preventing influenza among health care personnel

SAFARI-STEMI
2019, Safety and Efficacy of Femoral Access vs Radial Access in Patients with STEMI

SMART-CHOICE
2019, P2Y12 Inhibitor Monotherapy vs. Dual Antiplatelet Therapy in Patients Undergoing PCI

SONAR
2019, Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease

SPICE III
2019, Early Sedation with Dexmedetomidine in Critically Ill Patients

SPRINT MIND
2019, Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia

STOPDAPT-2
2019, One-Month vs. Standard 12-Month DAPT After Drug-Eluting Stent Implantation

TABLET
2019, Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception

THEMIS
2019, Ticagrelor in Patients with Stable Coronary Disease and Diabetes

THEMIS-PCI
2019, Ticagrelor in patients with diabetes and stable CAD with a history of previous PCI

TRANSIENT
2019, Timing of revascularization in patients with transient STEMI

TREAT
2019, Ticagrelor Versus Clopidogrel in Patients With STEMI Treated With Fibrinolysis

TRED-HF
2019, Withdrawal of treatment for HF in patients with recovered DCM

TWILIGHT
2019, Ticagrelor with or without Aspirin in High-Risk Patients after PCI

TiCAB
2019, Ticagrelor vs. aspirin in patients after coronary artery bypass grafting

Treat Stroke to Target
2019, A Comparison of Two LDL Cholesterol Targets after Ischemic Stroke

VIOLET
2019, Early High-Dose Vitamin D3 for Critically Ill, Vitamin D Deficient Patients

Vit D for bones
2019, Effect of high-dose vitamin D supplementation on volumetric bone density and bone strength

WRAP-IT
2019, Antibacterial Envelope to Prevent Cardiac Implantable Device Infection

2018

ADRENAL
2018, Glucocorticoids in Septic Shock

AIDA-WP2
2018, 5-Day nitrofurantoin vs single-dose fosfomycin for uncomplicated UTI in women

APROCCHSS
2018, Hydrocortisone + Fludrocortisone in Septic Shock

ARRIVE
2018, Aspirin for Primary Prevention in Adults at Moderate Cardiovascular Risk

ASCEND ASA
2018, Aspirin for primary prevention of CVD in DM

ASCEND N3
2018, N3 fatty acid supplements for primary prevention in DM

ASPREE
2018, Aspirin for Primary Prevention in Healthy Adults

ATTR-ACT
2018, Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy

AVERT
2018,�Apixaban to Prevent Venous Thromboembolism (VTE) in Patients with Cancer

Ambulatory BP and Mortality
2018, Ambulatory BP measurements and mortality

BICAR-ICU
2018, Sodium Bicarbonate in Severe Metabolic Acidaemia

Barber Cluster Trial
2018, Barbershop Interventions in Controlling Blood Pressure

Bezafibrate Trial
2018, Bezafibrate in Primary Biliary Cholangitis

CABANA
2018, Catheter Ablation for Atrial Fibrillation

CAMELLIA-TIMI 61
2019, Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients

CAPSTONE-1
2018, Baloxavir Marboxil for Uncomplicated Influenza

CASTLE-AF
2018, Catheter Ablation for Atrial Fibrillation with Heart Failure

CECCY
2018, Carvedilol for Prevention of Chemotherapy-Related Cardiotoxicity

CHECK-UP
2018, Checklist for Endotracheal Intubation of Critically Ill Adults

CIRT
2018, Low-dose methotrexate for the prevention of atherosclerotic events

COAPT
2018, Mitral valve repair in Patients with Heart failure

COMMANDER HF
2018, Rivaroxaban in Patients with Heart Failure, Sinus Rhythm, and Coronary Disease

CULPRIT-SHOCK
2018, Culprit lesion vs multivessel PCI in ACS with cardiogenic shock

Closed Loop Insulin Trial
2018, Closed-loop Insulin Delivery in Non-ICU patients

Colchicine cream in AK Trial
2018, 0�5% colchicine cream vs. photodynamic therapy in actinic keratosis

DAWN
2018, Mechanical Thrombectomy 6 to 24 Hours after Stroke

DEFUSE-3
2018, Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging

DIVA
2018, Drug-eluting stents versus bare-metal stents in saphenous vein grafts

EAGLES
2018, Cardiovascular Safety of Smoking Cessation Medications

EPCAT II
2018, Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty

EXTEND-IA TNK
2018, Tenecteplase vs Alteplase in Ischemic Stroke

GLOBAL LEADERS
2018, Ticagrelor plus aspirin for 1 month, followed by ticagrelor monotherapy for 23 months vs standard DAPT after PCI with DES

Hokusai VTE Cancer
2018, Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism

IDEAL-ICU
2018, Timing of renal-replacement therapy in patients with acute kidney injury and sepsis

KEYNOTE-407
2018, Pembrolizumab plus Chemotherapy for Squamous Non�Small-Cell Lung Cancer

LIBERTY ASTHMA QUEST
2018, Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma

MANAGE
2018, Dabigatran in myocardial injury after non-cardiac surgery

MARINER
2018, Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness

MERINO
2018, Piperacillin-Tazobactam vs Meropenem in Ceftriaxone resistant Infections

MIND-USA
2018, Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness

MITRA-FR
2018, Percutaneous Repair or Medical Treatment for Secondary Mitral Regurgitation

MOMENTUM 3
2018, Magnetically Levitated Cardiac Pump in Heart Failure

Metachronous Gastric Trial
2018, H-Pylori treatment in Metachronous Gastric Cancer

Metformin in CKD Cohort
2018, Metformin in CKD

NAVIGATE ESUS
2018, Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source

NELSON
2018, CT scan for screening lung cancer

ODYSSEY OUTCOMES
2018, Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome

PACIFIC
2018, Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC

PADIT
2018, Prevention of Arrhythmia Device Infection Trial

PAMPer
2018, Prehospital Plasma in Trauma Patients

PARAMEDIC2
2018, Epinephrine in Out-of-Hospital Cardiac Arrest

PIONEER-HF
2018, Angiotensin-neprilysin inhibition in acute decompensated heart failure

POET
2018, IV vs PO Antibiotics in Infective Endocarditis

POINT
2018, Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA

PRECISION
2018, MRI-Targeted or Standard Biopsy for Prostate-Cancer Diagnosis

PREDIMED
2018, Primary Prevention of Cardiovascular Disease with a Mediterranean Diet with Extra-Virgin Olive Oil or Nuts

PRESERVE
2018, Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine

PROACT
2018, Procalcitonin in Lower Respiratory Tract Infections

PReVENT
2018, Low vs Intermediate Tidal Volume Strategy in ICU Patients Without ARDS

REDUCE-IT
2018, Cardiovascular risk reduction with Icosapent ethyl for hypertriglyceridemia

REFRESH
2018, Restricted fluid resuscitation in suspected sepsis associated hypotension

SALT-ED
2018, Balanced crystalloids versus saline in non-critically ill adults

SCOT-HEART
2018, CTA vs standard care in preventing MI

SELECT-D
2018, Rivaroxaban vs LMWH (Dalteparin) in Patients With Cancer With VTE

SM-BOSS
2018, Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass on Weight Loss in Patients With Morbid Obesity

SMART-DATE
2018, 6-month versus 12-month or longer DAPT after PCI in ACS

SPACE
2018, Opioid vs Nonopioid Medications in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain

SPYRAL HTN-ON MED
2018, Renal Denervation in Uncontrolled Hypertension

SUP-ICU
2018, Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU

SYGMA-1
2018, Inhaled Combined Budesonide�Formoterol as Needed in Mild Asthma

TANGO I
2018, Effect of Meropenem-Vaborbactam vs Piperacillin-Tazobactam on complicated Urinary Tract Infection (UTI)

TARGET
2018, Energy-Dense versus Routine Enteral Nutrition in the Critically Ill

TRAPS
2018, Rivaroxaban vs. warfarin in high-risk patients with antiphospholipid syndrome

TRICS III
2018, Six-Month Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery

ULTIMATE
2018, IVUS vs angiography guided implantation of DES

VEST
2018, Wearable cardioverter-defibrillator after myocardial infarction

VITAL (N3)
2018, N3 fatty acid supplements for prevention of CVD and cancer

VITAL (Vitamin D)
2018, Vitamin D3 for prevention of CVD and cancer

WAKE-UP
2018, MRI guided thrombolysis with alteplase in stroke with unknown time of onset

2017

AIDA
2017, Bioresorbable Scaffolds versus Metallic Stents in Routine PCI

ALEX
2017, Alectinib versus Crizotinib in Untreated ALK-Positive Non�Small-Cell Lung Cancer

ALLHAT-LLT Elderly
2017, Effect of Statin Treatment vs Usual Care on Primary Cardiovascular Prevention Among Older Adults

AMAZES
2017, Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma

ART
2017, Lung Recruitment and Titrated PEEP vs Low PEEP in ARDS

ASSORT
2017, Early Versus Delayed Statin Therapy in Patients With Acute Ischemic Stroke

ATHOS-3
2017,�Angiotensin II for the Treatment of Vasodilatory Shock

ATTRACT
2017, Pharmacomechanical Catheter-Directed Thrombolysis for Deep-Vein Thrombosis

Aspirin for Preeclampsia
2017, Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia

CANTOS
2017, Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

CANVAS
2017, Canagliflozin in Type II DM

CLOSE
2017, Patent Foramen Ovale Closure or Anticoagulation vs. Antiplatelets after Stroke

COMPARE-ACUTE
2017, Fractional Flow Reserve Guided-Multivessel Angioplasty in Myocardial Infarction

COMPASS
2017, Rivaroxaban with or without ASA in stable CAD

DEFINE-FLAIR
2017, Use of the Instantaneous Wave-free Ratio or Fractional Flow Reserve in PCI

DETO2X
2017, Oxygen Therapy in Suspected Acute Myocardial Infarction

DMID
2017, Antibiotics for Smaller Skin Abscesses

EGPA Mepolizumab
2017, Mepolizumab for Eosinophilic Granulomatosis with Polyangiitis

EUCLID
2017, Ticagrelor versus Clopidogrel in Symptomatic Peripheral Artery Disease

EXSCEL
2017, Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes

FOURIER
2017, Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease

Gore REDUCE
2017, Patent Foramen Ovale Closure or Antiplatelet Therapy for Cryptogenic Stroke

HPS3/TIMI55-REVEAL
2017, Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease

IRONOUT-HF
2017, Oral iron therapy in HFrEF and anemia

ORBITA
2017, Percutaneous coronary intervention in stable angina

PATHWAY
2017, Tezepelumab in Adults with Uncontrolled Asthma

RE-DUAL PCI
2017, Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation

SPIRE 1
2017, Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients

SPIRE 2
2017, Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients

STRIVE
2017, Erenumab in Episodic Migraine

SURTAVI
2017, Surgical AVR or TAVR in intermediate-risk patients

SUSTAIN 4
2017, once-weekly semaglutide versus once-daily insulin glargine in type 2 diabetes

TROPICAL-ACS
2017, Guided de-escalation of antiplatelet treatment in patients with ACS undergoing PCI

Teprotumumab for Thyroid-Associated Ophthalmopathy
2017, Teprotumumab for Thyroid-Associated Ophthalmopathy

U-TURN
2017, Effect of an intensive lifestyle intervention on glycemic control in patients with type 2 diabetes

iFR-SWEDEHEART
2017, Instantaneous Wave-free Ratio versus Fractional Flow Reserve to Guide PCI

2016

35/39
2016, Labor Induction in Women 35 Years of Age or Older

AATAC
2016, Ablation vs. amiodarone for persistent atrial fibrillation in patients with CHF

AIRTRIP
2016, Effect of Anakinra on Recurrent Pericarditis Among Patients With Colchicine Resistance and Corticosteroid Dependence

AKIKI
2016, Renal Replacement Therapy in ICU

CLASSIC
2016, Restricting volumes of resuscitation fluid in adults with septic shock after initial management

DANISH
2016, Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure

EXCEL
2016, Everolimus-eluting stents or bypass surgery for left main coronary artery disease

FIRE AND ICE
2016, Cryoballoon or Radiofrequency Ablation for Paroxysmal Atrial Fibrillation

FLAME
2016, LABA + LAMA vs LABA + ICS for COPD

HYPRESS
2016, Effect of Hydrocortisone on Development of Shock Among Patients With Severe Sepsis

INO-VATE ALL
2016, Inotuzumab Ozogamicin versus Standard Therapy for Acute Lymphoblastic Leukemia

KEYNOTE-024
2016, Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer

LEADER
2016, Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes

LOTT
2016, Long-Term Oxygen for COPD with Moderate Desaturation

Lifestyle Modification in Infertility
2016, Lifestyle Program in Obese Infertile Women

MGTX
2016, Thymectomy in Myasthenia Gravis

MINDFULLNESS
2016, Effect of mindfulness-based stress reduction(MBSR) vs CBT or usual care on back pain in adults with chronic low back pain

NOBLE
2016, Percutaneous coronary angioplasty versus coronary artery bypass grafting in treatment of unprotected left main stenosis

NORSTENT
2016, Drug-Eluting (DES) or Bare-Metal Stents (BMS) for Coronary Artery Disease

PARTNER 2
2016, Transcatheter or Surgical Aortic Valve Replacement in Intermediate-Risk Patients

PIONEER AF-PCI
2016, Prevention of bleeding in patients with Atrial fibrillation undergoing PCI

PLEASE
2016, Longer-Term Therapy for Symptoms Attributed to Lyme Disease

POP-UP
2016, Pantoprazole or Placebo for Stress Ulcer Prophylaxis

RESCUEicp
2016, Decompressive Craniectomy for Traumatic Intracranial Hypertension

SAVE
2016, CPAP for Prevention of Cardiovascular Events in Obstructive Sleep Apnea

SOCRATES
2016, Ticagrelor versus aspirin in acute stroke or TIA

SSSS
2016, Fusion Surgery for Lumbar Spinal Stenosis

TITAN
2016, Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura

VANISH
2016, Ventricular Tachycardia Ablation versus Escalation of Antiarrhythmic Drugs

2015

3SITES
2015, Intravascular Complications of Central Venous Catheterization by Insertion Site

ANNEXA
2015, Andexanet for reversal of Factor Xa Inhibitors

ANRS IPERGAY
2015, On-demand preexposure prophylaxis in men at high risk for HIV-1 infection

BRIDGE
2015, Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation

COMBI-V
2015, Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib

CvLPRIT
2015. Complete versus lesion-only revascularization in patients undergoing primary PCI for STEMI and multivessel disease

DANAMI-3 PRIMULTI
2015, Complete revascularisation versus culprit lesion only PCI in STEMI and multivessel disease

EMPA-REG OUTCOMES
2015, Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

HEAT
2015, Acetaminophen for Fever in Critically Ill Patients with Suspected Infection

IMPROVE-IT
2015, Ezetimibe + statin in acute coronary syndrome (ACS)

INSIGHT START
2015, INSIGHT START: Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection

ISAR-TRIPLE
2015, Duration of Triple Therapy in Patients Requiring OAC After DES

MATRIX
2015, Bivalirudin or Unfractionated Heparin in Acute Coronary Syndromes
2015, Radial versus femoral access in patients with acute coronary syndromes

MEDIC
2015, Trial of Total Knee Replacement

MR CLEAN
2015, Intraarterial Treatment for Acute Ischemic Stroke

NEAT-HFpEF
2015, Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction (HFpEF)

PATHWAY-2
2015, Spironolactone for drug-resistant hypertension

PEGASUS-TIMI 54
2015, Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarction

PREPIC 2
2015, Effect of a Retrievable IVC Filter + Anticoagulation vs Anticoagulation Alone on Risk of Recurrent Pulmonary Embolism

PROMISE
2015, Outcomes of Anatomical versus Functional Testing for Coronary Artery Disease

PROPPR
2015, Transfusion of Plasma, Platelets, and Red Blood Cells in Severe Trauma

REVERT
2015, Postural modification to the standard Valsalva manoeuvre for emergency treatment of supraventricular tachycardias

SOME
2015, Cancer screening in unprovoked VTE

SPRINT
2015, Intensive Versus Standard Blood Pressure Control

STOP-IT
2015, Short-Course Antimicrobial Therapy for Intraabdominal Infection

STOP-IgAN
2015, Intensive Supportive Care plus Immunosuppression in IgA Nephropathy

STOPAH
2015, Prednisolone in Alcoholic Hepatitis

TECOS
2015, Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes

2014

ADJUST PE
2014, Age Adjusted D Dimer for PE

ALBIOS
2014, Albumin in Severe Sepsis and Septic Shock

CORAL
2014, Stenting and Medical Therapy for Atherosclerotic Renal-Artery Stenosis

CRYSTAL AF
2014, Cryptogenic Stroke and Underlying Atrial Fibrillation

DAPT
2014, 12 or 30 months of dual antiplatelet therapy after drug-eluting stents PCI

EMBRACE
2014, Atrial fibrillation in patients with cryptogenic stroke

FAMOUS-NSTEMI
2014, Fractional flow reserve vs. angiography in guiding management to optimize outcomes in NSTEMI

HPS2-THRIVE
2014, Effects of Extended-Release Niacin with Laropiprant in High-Risk Patients

INPULSIS
2014, Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

LESS
2014, Epidural Glucocorticoid Injections for Spinal Stenosis

PARADIGM-HF
2014, Angiotensin-neprilysin inhibition versus enalapril in heart failure

PEITHO
2014, Fibrinolysis for Patients with Intermediate-Risk Pulmonary Embolism

POISE-2
2014, Aspirin in Patients Undergoing Noncardiac Surgery

ProCESS
2014, A Randomized Trial of Protocol-Based Care for Early Septic Shock

SEPSISPAM
2014, High versus low blood-pressure target in patients with septic shock

SYMPLICITY HTN-3
2014, Renal Denervation for Resistant Hypertension

TOPCAT
2014, Spironolactone in HFpEF

TRISS
2014, Restrictive vs Liberal Transfusion in Septic Shock

TTM
2014, 33 vs. 36�C body temperature after cardiac arrest

VALENCE
2014, Sofosbuvir and ribavirin in HCV

2013

AMPLIFY
2013, Apixaban for VTE

ATLAS
2013, 10 years vs. 5 years of tamoxifen in breast cancer

BLOCK HF
2013, Biventricular versus Right Ventricular Pacing in Heart Failure Patients with Atrioventricular Block

CHAMPION PHOENIX
2013, Cangrelor vs Clopidogrel in PCI

CHANCE
2013, Clopidogrel with aspirin in acute minor stroke or transient ischemic attack

CRISTAL
2013, Effects of fluid resuscitation with colloids vs. crystalloids on mortality in hypovolemic shock

CYTO-PV
2013, Cardiovascular Events and Intensity of Treatment in Polycythemia Vera

ENGAGE AF-TIMI 48
2013, Edoxaban versus warfarin in patients with atrial fibrillation

EPCAT I
2013, Aspirin Versus LMWH for Extended VTE Prophylaxis After Total Hip Arthroplasty

FIDELITY
2013, Arthroscopic Partial Meniscectomy versus Sham Surgery for a Degenerative Meniscal Tear

ICAP
2013, Colchicine for Acute Pericarditis

Look AHEAD
2013, Cardiovascular Effects of Intensive Lifestyle Intervention in Type 2 Diabetes

MAGELLAN
2013, Rivaroxaban for Thromboprophylaxis in Acutely Ill Medical Patients

METEOR
2013, Surgery vs Physical Therapy for a Meniscal Tear and Osteoarthritis

MIDA
2013, Early Surgical Intervention vs Watchful Waiting for MR Due to Flail Mitral Valve Leaflets

MOPETT
2013, Low-dose tPA for submassive PE

MR RESCUE
2013, A Trial of Imaging Selection and Endovascular Treatment for Ischemic Stroke

ORBIT-AF Registry
2013, Aspirin and OAC in Atrial Fibrillation

PLACIDE
2013, Lactobacilli and bifidobacteria in preventing antibiotic-associated and C.diff diarrhea

PRAMI
2013, Randomized trial of preventative angioplasty in myocardial infarction

PROSEVA
2013, Prone Positioning in Severe Acute Respiratory Distress Syndrome (ARDS)

RE-ALIGN
2013, Dabigatran versus warfarin in patients with mechanical heart valves

RED-HF
2013, Treatment of Anemia with Darbepoetin Alfa in Systolic Heart Failure

REDOXS
2013, Glutamine and Antioxidants in Critically Ill Patients

REDUCE
2013, Short term steroids in COPD exacerbation

RELAX
2013, Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in HFpEF

RESPECT
2013, Closure of Patent Foramen Ovale versus Medical Therapy after Cryptogenic Stroke

Rifaxamin in HE
2013, Rifaxamin in hepatic encephalopathy

SAVOR-TIMI
2013, Saxagliptin and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus

SPS3-BP
2013, Blood-pressure targets in patients with recent lacunar stroke

Transfusion in UGIB
2013, Transfusion Strategies for Acute Upper Gastrointestinal Bleeding

VA NEPHRON-D
2013, Combined angiotensin inhibition for the treatment of diabetic nephropathy

WOEST
2013, Clopidogrel with or without aspirin in patients taking OAC and undergoing PCI

2012

ATLAS ACS-2
2012, Rivaroxaban in Acute Coronary Syndrome

CARRESS HF
2012, Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome

CLOSURE I
2012, Closure or Medical Therapy for Cryptogenic Stroke with Patent Foramen Ovale

COLONPREV
2012, FIT vs. colonoscopy for colon cancer screening

COMFORT-I
2012, Ruxolitinib for Myelofibrosis

COMFORTABLE AMI
2012, Effect of Biolimus-Eluting Stents With Biodegradable Polymer vs Bare-Metal Stents on Cardiovascular Events Among Patients With STEMI

EASE
2012, Early Surgery versus Conventional Treatment for Infective Endocarditis

EINSTEIN PE
2012, Rivaroxaban for Acute PE

EMILIA
2012, Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer

EVOLVE
2012, Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing Dialysis

FAME 2
2012, Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease

FREEDOM
2012, Percutaneous Coronary Intervention (PCI) vs CABG in Patients with Diabetes and multivessel CAD

IABP-SHOCK II
2012, Intraaortic Balloon Pump for Myocardial Infarction with Cardiogenic Shock

ORIGIN
2012, n�3 Fatty Acids and Cardiovascular Outcomes in Patients with Dysglycemia

PROTECT II
2012, Impella 2.5 Versus Intra-Aortic Balloon Pump (IABP) in Patients Undergoing High-Risk PCI

PROWESS-SHOCK
2012, Activated protein C (DrotAA) in Sepsis

RAMPART
2012, Intramuscular versus Intravenous Therapy for Prehospital Status Epilepticus

RENAAL
2001, Losartan in diabetic nephropathy

RESET
2012, 3-Month Dual Antiplatelet Therapy Following Zotarolimus-Eluting Stent Implantation

SPS3 Clopidogrel-ASA
2021, Clopidogrel +aspirin in patients with recent lacunar stroke

STAMPEDE
2012, Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes

WARFASA
2012, Aspirin for Recurrent VTE

2011

ACT
2011, Acetylcysteine in Coronary Angiography

AIM HIGH
2011, Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy

ARISTOTLE
2011, Apixaban vs. warfarin in atrial fibrillation

ASCEND-HF
2011, Effect of Nesiritide in Patients with Acute Decompensated Heart Failure

AVERROES
2011, Apixaban in Patients with Atrial Fibrillation

Antimicrobials in Otitis Media
2011, Antimicrobial Treatment for Acute Otitis Media

DOSE
2011, Furosemide in Acute Decompensated Heart Failure

EMPHASIS-HF
2011, Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms

EXTRA
2011, Omalizumab in Severe Allergic Asthma

Fidaxomicin in C. diff Infection
2011, Fidaxomicin versus vancomycin for Clostridium difficile infection

HPTN 052
2011, Prevention of HIV-1 Infection with Early Antiretroviral Therapy

NLST
2011, Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening

PARTNER A
2011, Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients

PREVENT TB
2011, Three Months of Rifapentine and Isoniazid for Latent Tuberculosis Infection

RIVAL
2011, Radial versus femoral access for coronary angiography and intervention in patients with ACS

ROCKET AF
2011, Rivaroxaban vs. warfarin in atrial fibrillation

SHARP
2011, Lowering LDL cholesterol with simvastatin plus ezetimibe in patients with CKD

STICH
2011, Coronary-Artery Bypass Surgery in Patients with Left Ventricular Dysfunction

2010

ACCORD BP
2010, Effects of Intensive Blood-Pressure Control in Type 2 Diabetes Mellitus

ACURASYS�
2010, Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome

BALANCE
2010, Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder

CLARITY
2010, Oral Cladribine for Relapsing Multiple Sclerosis

COGENT
2010, Clopidogrel with or without Omeprazole in Coronary Artery Disease

CRASH-2
2010, Effects of tranexamic acid in trauma patients with significant haemorrhage

CREST
2010, Stenting versus CEA in Carotid-Artery Stenosis

EVAR-1
2010, Endovascular versus Open Repair of Abdominal Aortic Aneurysm

HART-D
2010, Effect of aerobic and resistance training on hemoglobin A1c Levels in patients with type 2 diabetes

IDEAL
2010, Early versus Late Dialysis in Patients with ESRD

KANON
2010, Treatment for Acute Anterior Cruciate Ligament Tears

PANTER
2010, A Step-up Approach or Open Necrosectomy for Necrotizing Pancreatitis

PRORATA
2010, Procalcitonin guided antibiotic therapy in critically ill patients

RACE II
2010, Strict vs Lenient Control of Heart Rate in Atrial Fibrillation

RAFT
2010, Cardiac-Resynchronization Therapy for Mild-to-Moderate Heart Failure

RAVE
2010, Rituximab versus cyclophosphamide for ANCA-associated vasculitis

SHIFT
2010, Ivabradine and outcomes in chronic heart failure

SOAP II
2010, Comparison of Dopamine and Norepinephrine in the Treatment of Shock

iPrEx
2010, Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men

2009

ACTIVE A
2009, Effect of Clopidogrel Added to Aspirin in Patients with Atrial Fibrillation

ASTRAL
2009, Revascularization versus Medical Therapy for Renal-Artery Stenosis

AURORA
2009, Rosuvastatin and Cardiovascular Events in Patients Undergoing Hemodialysis

B-CONVINCED
2009, Beta-blocker continuation vs. Interruption in patients with congestive heart failure

CYCLOPS
2009, Pulse vs daily oral cyclophosphamide for induction of remission in ANCA vasculitis

ERSPC
2009, Screening and Prostate-Cancer Mortality

FAIR-HF
2009, Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency

FAME
2009, Fractional Flow Reserve versus Angiography for Guiding Percutaneous Coronary Intervention

HEARTMATE II
2009, Advanced Heart Failure Treated with Continuous-Flow Left Ventricular Assist Device

NICE-SUGAR
2009, Intensive versus Conventional Glucose Control in Critically Ill Patients

PLATO
2009, Ticagrelor versus clopidogrel in patients with acute coronary syndromes

PROTECT-AF
2009, Percutaneous Closure of LAA in atrial fibrillation

RE-COVER
2009, Dabigatran versus Warfarin in the Treatment of Acute Venous Thromboembolism

RECORD
2009, Rosiglitazone for CV outcomes in oral agent combination therapy for type 2 diabetes

RENAL
2009, Intensity of Continuous Renal-Replacement Therapy in Critically Ill Patients

SYNTAX
2009, PCI vs CABG in severe CAD

TIMACS
2009, Early versus Delayed Invasive Intervention in Acute Coronary Syndromes

TREAT
2009, Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney Disease

VADT
2009, Glucose Control and Vascular Complications in Veterans with Type 2 Diabetes

2008

3CPO
2008, Noninvasive Ventilation in Acute Cardiogenic Pulmonary Edema

ACCOMPLISH
2008, Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension in High-Risk Patients

ACCORD
2008, Effects of Intensive Glucose Lowering in Type 2 Diabetes

ADVANCE
2008, Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes

AF-CHF
2008, Rhythm Control versus Rate Control for Atrial Fibrillation and Heart Failure

ATN
2008, Intensity of renal support in critically ill patients with acute kidney injury

CORTICUS
2008, Hydrocortisone Therapy for Patients with Septic Shock

ECASS III
2008, Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke

ENHANCE
2008, Simvastatin with or without ezetimibe in familial hypercholesterolemia

HYVET
2008, Treatment of Hypertension in Patients 80 Years of Age or Older

JUPITER
2008, Rosuvastatin for prevention of CV events

POISE
2008, Metoprolol succinate in patients undergoing surgery

PRoFESS
2008, Aspirin and Extended-Release Dipyridamole versus Clopidogrel for Recurrent Stroke

UPLIFT
2008, Tiotropium in Chronic Obstructive Pulmonary Disease

VASST
2008, Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock

2007

CORONA
2007, Rosuvastatin in Older Patients with Systolic Heart Failure

COURAGE
2007, PCI for stable CAD

EVEREST Outcome
2007, Tolvaptan in Patients Hospitalized for Worsening Heart Failure

RABBIT2
2007, Basal-bolus insulin in inpatients with DM

STEP-BD
2007, Adjunctive Antidepressant Treatment for Bipolar Depression

SURVIVE
2007, Levosimendan in acute decompensated heart failure

TORCH
2007, Salmeterol and Fluticasone Propionate in Chronic Obstructive Pulmonary Disease

TRITON-TIMI 38
2007, Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndromes

2006

ACTIVE W
2006, Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation

AGE
2006, Mammographic screening from age 40 years

Ancillary DIG
2006, Digoxin in Heart failure with preserved ejection fraction

CHARISMA
2006, Aspirin + clopidogrel vs. aspirin for CVD prevention

CHOIR
2006, Erythropoetin for anemia in non-dialysis CKD

COMBINE
2006, Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence

ESPIRIT
2006, Aspirin plus dipyridamole versus aspirin alone after ischemic stroke

FRISC II
2006, Invasive compared with non-invasive treatment in unstable coronary artery disease

OASIS-5
2006, Comparison of fondaparinux and enoxaparin in acute coronary syndromes

OAT
2006, Coronary Intervention for Persistent Occlusion after Myocardial Infarction

SMART
2006, Usual pharmacotherapy for asthma versus usual pharmacotherapy plus salmeterol

SPARCL
2006, High-dose atorvastatin after stroke or transient ischemic attack (TIA)

STAR
2006, Effects of Tamoxifen vs Raloxifene on the Risk of Developing Invasive Breast Cancer

2005

BeSt
2005, DMARD with prednisone or infliximab in RA

CARE-HF
2005, The Effect of Cardiac Resynchronization on Morbidity and Mortality in Heart Failure

COMMIT
2005, Metoprolol after acute MI

EDIC
2005, Intensive diabetes treatment and CV disease in patients with Type 1 diabetes

ESCAPE
2005, Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness

HERA
2005, Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer

SCD-HeFT
2005, Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure

TNT
2005, Intensive lipid lowering with atorvastatin in patients with Stable CAD

WASID
2005, Warfarin or Aspirin for Symptomatic Intracranial Arterial Stenosis

2004

A-HeFT
2004, Combination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure

CARP
2004, Coronary-Artery Revascularization before Elective Major Vascular Surgery

DEFINITE
2004, Prophylactic Defibrillator Implantation in Patients with Nonischemic Dilated Cardiomyopathy

DINAMIT
2004, Prophylactic Use of an Implantable Cardioverter�Defibrillator after Acute Myocardial Infarction

IALT
2004, Cisplatin-based adjuvant chemotherapy in patients with completely resected NSCLC

MATCH
2004, Aspirin and clopidogrel compared with clopidogrel alone after stroke

OCTAVE
2004, Omapatrilat and enalapril in patients with hypertension

PROVE IT
2004, Intensive versus Moderate Lipid Lowering with Statins after Acute Coronary Syndromes

SYNERGY
2004, Enoxaparin vs unfractionated heparin in high-risk patients with UA/NSTEMI

2003

CHARM-Added
2003, Effects of candesartan in patients with HFrEF taking ACE inhibitors

CHARM-Preserved
2003, Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction (HFpEF)

CLOT
2003, LMWH vs a coumarin for the prevention of recurrent VTE in patients with cancer

COMET
2003, Comparison of Carvedilol and Metoprolol in Chronic Heart Failure

EPHESUS
2003, Eplerenone in patients with LV dysfunction after MI

EUROPA
2003, Efficacy of perindopril in reduction of CV events among patients with stable CAD

NETT
2003, Lung-volume-reduction surgery versus medical therapy for severe emphysema

VALIANT
2003, Valsartan vs. captopril in patients with acute MI and HF

2002

AFFIRM
2002, Rate control vs Rhythm control in Atrial Fibrillation

ALIVE
2002, Amiodarone as Compared with Lidocaine for Shock-Resistant Ventricular Fibrillation

ALLHAT
2002, Antihypertensive drugs to prevent Heart Attack

ALLHAT-LLT
2002, Major Outcomes in Moderately Hypercholesterolemic, Hypertensive Patients Randomized to Pravastatin vs Usual Care

BREATHE-1
2002, Bosentan Therapy for Pulmonary Arterial Hypertension

CADILLAC
2002, Angioplasty with Stenting, with or without Abciximab, in Acute Myocardial Infarction

COPERNICUS
2002, Effect of Carvedilol on the Morbidity of Patients With Severe Chronic Heart Failure

DAVID
2002, Dual-Chamber Pacing or Ventricular Backup Pacing in Patients With an Implantable Defibrillator

DPP
2002, Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

HACA
2002, Hypothermia in Cardiac Arrest

Hypothermia in Cardiac Arrest
2002, Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia

LIFE
2002, Losartan or atenolol for hypertension and LVH

MADIT-II
2002, Prophylactic Implantation of a Defibrillator in Patients with Myocardial Infarction and Reduced Ejection Fraction

MIRACLE
2002, Cardiac Resynchronization in Chronic Heart Failure

SADHART
2002, Sertraline for depression after ACS

2001

CAPRICORN
2001, Effect of carvedilol on outcome after MI in patients with LV dysfunction

CURE
2001, Effects of Clopidogrel plus Aspirin in Patients with NSTEMI

IDNT
2001, Irbesartan in diabetic nephropathy

MIRACL
2001, Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes

REMATCH
2001, Long-Term Use of a Left Ventricular Assist Device for End-Stage Heart Failure

RENAAL
2001, Losartan in diabetic nephropathy

Rivers Trial
2001, Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock

TACTICS TIMI 18
2001, Early Invasive and Conservative Strategies in Patients with Unstable Coronary Syndromes Treated with Tirofiban

2000

CBT, Imipramine in Panic Disorder
2000, Cognitive-Behavioral Therapy, Imipramine, or Their Combination for Panic Disorder

HOPE
2000, ACE inhibitors, ramipril in high cardiovascular risk patients

1999

ARREST
1999, Amiodarone for Resuscitation after Out-of-Hospital Cardiac Arrest Due to Ventricular Fibrillation

Albumin in SBP
1999, IV albumin in patients with cirrhosis and SBP

MEDENOX
1999, Enoxaparin for Prevention of VTE in Acutely Ill Medical Patients

MERIT-HF
1999, Effect of metoprolol CR/XL in chronic heart failure

RALES
1999, The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure

SHOCK
1999, Early Revascularization in Acute Myocardial Infarction Complicated by Cardiogenic Shock

TRICC
1999, Transfusion requirements in critical care

1998

LIPID
1998, Pravastatin in patients with coronary heart disease

NASCET
1998, Carotid Endarterectomy in Patients with Symptomatic Moderate or Severe Stenosis

NSABP P-1
1998, Tamoxifen for Prevention of Breast Cancer

PREPIC
1998, Vena Caval Filters in Prevention of Pulmonary Embolism in Patients with Proximal Deep-Vein Thrombosis

TONE
1998, Sodium Reduction and Weight Loss in the Treatment of Hypertension in Older Persons

UKPDS 33
1998, Intensive blood-glucose control with sulphonylureas or insulin in type 2 diabetes

1997

DASH
1997, Effects of Dietary Patterns on Blood Pressure

DIG
1997, Digoxin in Heart failure with reduced ejection fraction

ESSENCE
1997, Enoxaparin vs Unfractionated Heparin for UA/NSTEMI

IST
1997, Aspirin, subcutaneous heparin, both, or neither in acute ischemic stroke

1996

CAPRIE
1996, Clopidogrel versus aspirin in patients at risk of ischaemic events

1995

MSH
1995, Effect of Hydroxyurea on the Frequency of Painful Crises in Sickle Cell Anemia

WOSCOPS
1995, Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia

1993

CSG
1993, Angiotensin-Converting-Enzyme Inhibition with Captopril on Diabetic Nephropathy

DCCT
1993, Intensive Treatment of Diabetes in patients with Type I Diabetes

1992

CONSENSUS II
1992, Effects of the Early Administration of Enalapril on Mortality in Patients with Acute MI

ONTT
1992, Corticosteroids in the Treatment of Acute Optic Neuritis

1991

CAST I
1991, Antiarrhythmics post-MI

NASCET (severe stenosis)
1991, Carotid Endarterectomy in Symptomatic Patients with High-Grade Carotid Stenosis

SOLVD
1991, Enalapril for Survival in Patients with Congestive Heart Failure

1987

AZT
1987, Azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex

CONSENSUS
1987, Effects of Enalapril on Mortality in Severe Congestive Heart Failure