Colchicine for Stroke Prevention (CHANCE-3 Trial) 📍 Study Type: Randomized, placebo-controlled trial🏥 Setting: 244 hospitals in China👥 Participants: 8,343 patients (age ≥40) with minor/moderate ischemic stroke or TIA & hs-CRP ≥2 mg/L Intervention vs. Control 💊 Colchicine Group (n=4,176)• 0.5 … Read More
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POST-TNK Trial: Intra-Arterial Tenecteplase in Acute Stroke
Visual Summary of POST-TNK Trial Objective:To evaluate the efficacy and safety of intra-arterial tenecteplase in patients with large vessel occlusion stroke achieving near-complete to complete reperfusion after EVT. Design & Participants: Interventions:Patients were randomized into two groups: Primary Outcome:Freedom from … Read More
ATTENTION Trial: Endovascular Treatment for Acute Basilar-Artery Occlusion
Published in the New England Journal of Medicine (2022), the ATTENTION Trial is a landmark study exploring the efficacy and safety of endovascular treatment (EVT) for patients with acute basilar artery occlusion (BAO). Here’s an in-depth look at the findings … Read More
ATTEST-2 Trial: Tenecteplase vs. Alteplase for Stroke
ATTEST-2 Trial — Comparing Tenecteplase and Alteplase for Acute Stroke Management Introduction In recent years, the quest for optimal treatments for acute ischemic stroke has intensified, with the goal of improving outcomes and accessibility of care. The ATTEST-2 trial, published … Read More
ARCADIA Trial: Apixaban After Cryptogenic Stroke
The ARCADIA trial, published in JAMA in 2024, compared the efficacy of apixaban versus aspirin in preventing recurrent strokes in patients with cryptogenic stroke and atrial cardiopathy. Key Findings: Conclusion: In patients with cryptogenic stroke and evidence of atrial cardiopathy … Read More
INTERACT4 Trial: Ambulance care for Stroke
INTERACT4 Trial Intensive Ambulance-Delivered Blood-Pressure Reduction in Hyperacute Stroke A multicentre, randomized, open-label trial Objective:To determine the effect of prehospital treatment of elevated systolic blood pressure (SBP) in patients with recent onset of symptoms concerning for acute stroke. 2404 Patients … Read More
ARTESIA Trial: Apixaban for Subclinical AFib
ARTESIA Trial Summary The ARTESIA trial, which stands for “Apixaban for Stroke Prevention in Subclinical Atrial Fibrillation,” was a landmark study aimed at comparing the efficacy and safety of apixaban versus aspirin in patients with subclinical atrial fibrillation (AF). The … Read More
ELAN Trial: Early vs. Later Initiation of DOAC in Acute Ischemic Stroke and Atrial Fibrillation
ELAN Trial Summary Introduction:The ELAN trial aimed to investigate the optimal timing of initiating direct oral anticoagulants (DOACs) in individuals with atrial fibrillation (AF) who had experienced an acute ischemic stroke. The study compared early anticoagulation (initiated within 48 hours … Read More
WAKE-UP Trial: MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset
WAKE-UP Trial Summary The WAKE-UP trial aimed to investigate the potential benefits of intravenous alteplase, a thrombolytic agent, in treating acute stroke patients with an unknown time of onset. Current guidelines recommend intravenous thrombolysis only if the time since symptom … Read More
BASICS Trial: Endovascular Therapy for Basilar Stroke
2021 BASICS TRIAL Endovascular therapy for stroke due to basilar-artery occlusion multicenter, open-label, randomized controlled trial M Objective: To determine effectiveness of endovascular therapy in patients with stroke caused by basilar-artery occlusion. 300 patients. Inclusion criteria: Patients aged ≥ 18 … Read More