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HYPRESS Trial (2016): Effect of Hydrocortisone on Development of Shock Among Patients With Severe Sepsis

HYPRESS trial visual abstract

HYPRESS Trial Summary: Keh D, et al. randomized 380 patients with sepsis defined by ≥2 SIRS criteria, proven infection, and ≥1 organ with new dysfunction to either IV hydrocortisone or placebo. The objective was to assess if early hydrocortisone therapy reduces progression to septic shock compared to placebo in patients with severe sepsis. The results showed no difference in the development of septic shock in both groups P=0.70. The authors of HYPRESS trial concluded that among adults with severe sepsis not in septic shock, use of hydrocortisone compared with placebo did not reduce the risk of septic shock within 14 days.

Source: JAMA

APROCCHSS Trial: Hydrocortisone plus Fludrocortisone for Adults with Septic Shock

aprocchss trial visual abstract on hydrocortisone plus fludrocortisone in septic shock

The APROCCHSS trial clinically analyze the combination of steroid therapy in patients with septic shock and shows significant mortality benefit.

Source: NEJM

STEP Trial: Adjunct prednisone therapy for patients with community-acquired pneumonia

Source: The LANCET

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