TAME Trial Summary The TAME trial investigated the impact of mild hypercapnia versus normocapnia on neurologic outcomes in adults with coma who were resuscitated after out-of-hospital cardiac arrest. Current guidelines recommend normocapnia, but mild hypercapnia has been suggested to enhance … Read More
resuscitation
WATERFALL Trial Summary: Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis
WATERFALL Trial Summary The WATERFALL trial aimed to evaluate the effectiveness and safety of early aggressive hydration in the management of acute pancreatitis. While early aggressive hydration is a commonly recommended approach, limited evidence exists to support this practice. Conducted … Read More
ANDROMEDA SHOCK Trial: Resuscitation in Septic Shock
ANDROMEDA-SHOCK: Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels in Septic Shock Multicenter, randomized trial conducted at 28 intensive care units in 5 countries 424 patients with septic shock were randomized to to a step-by-step … Read More
WATERFALL Trial Summary: Fluids in Pancreatitis
2022 WATERFALL TRIAL Aggressive or moderate fluid resuscitation in acute pancreatitis multicenter, open-label, parallel-group, superiority, randomized controlled trial Objective: To evaluate the safety & efficacy of aggressive fluid resuscitation as compared with moderate fluid resuscitation for the management of acute … Read More
AMACING Trial Summary: IV Hydration for CIN
2017 AMACING TRIAL Prophylactic hydration to protect renal function from intravascular iodinated contrast material in patients at high risk of contrast-induced nephropathy. M Single-center, randomised, parallel-group, open-label, phase 3, non-inferiority trial 660 patients Objective: To evaluate the impact of prophylactic … Read More
3SITES Trial Summary: Central Venous Catheterization Insertion Site
2015 3SITES TRIAL Intravascular complications of central venous catheterization by insertion site Multicenter, randomized controlled trial Objective: To evaluate the risk of catheter related bloodstream infection or symptomatic catheter related deep-vein thrombosis in an adult patient who had been admitted … Read More
SMART-MED Trial Summary: Balanced Crystalloids versus Saline in Critically Ill
2018 SMART-MED & SMART-SURG TRIAL Balanced crystalloids versus saline in critically ill adults Pragmatic, unblinded, cluster-randomized, multiple-crossover trial Objective: To determine whether administration of balanced crystalloids reduce a 30 day composite outcome of death, new renal replacement therapy or persistent … Read More
PLUS Trial Summary: Balanced Multielectrolyte Solution in Critically Ill
2022 PLUS TRIAL Balanced multi electrolyte solution versus saline in critically ill adults Investigator initiated, double-blind, parallel-group, randomised controlled trial d a Objective: To assess whether the use of balanced multielectrolyte solution (BMES) in preference to 0.9% sodium chloride solution … Read More
CLASSIC Trial Summary: Restriction of IVF in Septic Shock
2022 CLASSIC TRIAL Restriction of Intravenous Fluid in ICU Patients with Septic Shock Multicenter, international, randomized controlled trial ca Objective: To investigate whether the restriction of Intravenous Fluid in ICU Patients with Septic Shock improves 90-day survival? unipro 1554 Patients … Read More
SHENFU Trial Summary: Shenfu Injection After in hospital Cardiac Arrest
2017 SHENFU TRIAL Efficacy and safety of combination therapy of Shenfu injection and post-resuscitation bundle in patients with return of spontaneous circulation(ROSC) after in-hospital cardiac arrest Prospective,randomized controlled clinical study Objective:To evaluate the efficacy,safety & improvement in mortality of combined … Read More