2000, Effect of ACE inhibitors, ramipril on cardiovascular morbidity and mortality, NEJM HOPE Trial Summary HOPE – “Effects of an Angiotensin-Converting-Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients’ was a randomized, double-blinded, multi-national (267 centers), placebo-controlled, clinical trial (recruited patients between 1993 and 1995), which investigated the role of ACE inhibitor (ramipril 10mg oral..

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