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A Placebo-controlled Trial of Bezafibrate in Primary Biliary Cholangitis Trial Summarized by: Hajra Munawar, MBBS Hasan Shafiq, MD Contribution to literature This trial revealed that the use of the Bezafibrate (PPAR-a agonist )add-on therapy with ursodeoxycholic acid (UDCA) in patients with primary biliary cholangitis, normalizes the serum levels of alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase,..
The use of steroids vs Pentoxifylline in severe alcoholic hepatitis has long been debated. The STOPAH trial published in NEJM in 2015 was a strong 2×2 factorial design, randomized trial that established that neither pentoxifylline nor prednisolone provided significant survival benefit in patients with severe alcoholic hepatitis. Take a look at my visual abstract for..
Contribution by Leon Averbukh, Internal Medicine UConn Health Source: JAMA Neurology