Tag: coronary artery disease

COMMANDER HF Trial (2018): Rivaroxaban in Patients with Heart Failure, Sinus Rhythm, and Coronary Disease

COMMANDER HF Trial Summary: Zannand F et al. randomized 5,022 patients with coronary artery disease and heart failure to undergo treatment with either rivaroxaban or a placebo. The primary objective of the study was to assess if rivaroxaban could reduce thrombin production and improve outcomes in patients with CAD and HF. The results showed that rivaroxaban..

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COURAGE: PCI vs Medical Therapy in Stable CAD

2007, PCI + medical therapy vs medical therapy only in stable coronary artery disease, NEJM Courage Trial Summary COURAGE was a randomized, open label, multicenter (50 centers in US & Canada), co-industry sponsored, clinical trial which tested the hypothesis that PCI with optimal medical therapy (OMT) is superior to OMT alone in reducing primary outcome..

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ATLAS ACS-2: Rivaroxaban after ACS

The ATLAS ACS-2 trial tested the use of rivaroxaban in addition to standard dual antiplatelet therapy in patients with acute coronary syndrome. The results showed a reduction in the composite of CV mortality, recurrent MI, and stroke, but increased the risk of nonfatal bleeding. 2012, ATLAS ACS-2 Trial Visual Abstract: Rivaroxaban after ACS, NEJM

COMPASS Trial: Rivaroxaban plus aspirin in stable cardiovascular disease

Does adding rivaroxaban to aspirin therapy in patients with stable cardiovascular disease affect outcomes? This was the question answered by the large-sized multi-center COMPASS trial that evaluated the combination of rivaroxaban and aspirin and compared it with aspirin alone. The results showed moderate improvement in outcomes at the expense of increased bleeding risk. Source: NEJM

Radial-Artery or Saphenous-Vein Grafts in CABG

Current ACC/AHA guidelines recommend (IIb) radial artery grafting for >70% LAD stenosis. Most surgeons, however, still prefer saphenous vein grafts in addition to LIMA for LAD stenosis. The following combines the population of 6 RCTs to perform a individual based analysis and showed that radial artery grafting has significant benefits over saphenous vein grafts in..

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