In 2013, Dr. Villanueva et al. randomly assigned over 921 patients with upper gastrointestinal bleed who presented with either hematemesis or melena to either low transfusion goal of >7 threshold or greater transfusion goal of >9 threshold. Their goal was to assess all-cause mortality in these patients. Patients who received restrictive transfusion showed an almost double..
2006, CHOIR trial: anemia correction in patients with CKD, NEJM