Tag: atrial fibrillation

BRIDGE Trial (2015): Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation

BRIDGE Trial Summary: Douketis JD et al. randomized 1,884 patients on warfarin (INR 2-3 for ≥3m) with AF or A-flutter and CHADS2 Score ≥1 to LMWH: dalteparin (100 IU/kg BID) or placebo. The objective was to assess if bridging anticoagulation reduce rates of arterial thromboembolism compared to no bridging in patients with atrial fibrillation undergoing..

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AF-CHF Trial (2008): Rhythm Control versus Rate Control for Atrial Fibrillation and Heart Failure

  AF-CHF Trial Summary: Roy D et al. randomized 1,376 patients with nonvalvular atrial fibrillation and HFrEF (LVEF ≤35% and NYHA II-IV symptoms) were randomized to rhythm control (pharmacologic or electrical approach) or rate control (target <80 bpm at rest). The objective was to assess if rhythm-control reduce CV mortality in patients with AF and..

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RACE II: Strict vs Lenient Control of Heart Rate in Atrial Fibrillation

  2010, Heart Rate Control in patients with Atrial Fibrillation in Preventing CV events, NEJM RACE II Visual Summary RACE II was a randomized, prospective, open label, multicenter (33 centers in Netherlands), parallel-group,non-industry sponsored, controlled noninferiority trial investigatingthe role of lenient ratecontrol (HR<110 bpm) versus strict rate control (HR<80 bpm) in preventing cardiovascular events in..

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