Tag: ARB

VALIANT Trial (2003): Valsartan, Captopril, or Both in Myocardial Infarction

VALIANT Trial Summary: Pfeffer et al. randomized 14,703 patients with acute MI within prior 10 days complicated by HF and/or LVEF ≤35% to either valsartan or captopril or combination of both. The objective was to assess the efficacy of ARBs compared with ACE-I in patients in the post-MI period complicated by HF and/or LV systolic dysfunction…

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RENAAL Trial: Losartan in Patients with Type 2 Diabetes and Nephropathy

Source: NEJM RENAAL Trial Key Points1. Losartan was found to have significant reno-protective role in patients with type II diabetes and nephropathy.2. Losartan did not affect mortality in this patient population.3. Proteinuria significant improved in patients taking losartan compared to placebo.4. The IDNT trial tested irbesartan and reported similar renoprotective role in diabetic nephropathy. Guideline Recommendations based on RENAAL Trial: The..

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