2015, Short-Course Antimicrobial Therapy for Intraabdominal Infection, NEJM
STOP-IT Trial Key Points:
- A shorter course (3-5 days) of antibiotics was found to be non-inferior when compared to
traditionalcourse of 4 to 7 or 7 to 14 days. Importantpoint was to adequately control the source which means draining the abscess in case there is one or any other nidus of infection.
Guidelines Related to STOP-IT trial
The 2009 IDSA guidelines suggested 4-7 days course of antibiotics once the source is adequately controlled. The STOP-IT trial tested more restrictive therapy of 3 to 5 days of antibiotics and found no difference in outcomes. The study addressed an important issue