The SMART-DATE trial tested the hypothesis as to whether 6 months of dual antiplatelet therapy (DAPT) is non-inferior to 12 months of DAPT in patients who underwent percutaneous coronary intervention (PCI) with drug-eluting stents (DES) and require DAPT. Source
SMART-DATE Trial Key Points:
6 months DAPT was found to be
The SMART-DATE trial tested the shorter duration and is comparable to DAPT trial which tested 18 months duration of DAPT versus 12 months standard management.
Guidelines based on SMART-DATE trial
The last ACC/AHA guidelines were before this trial and recommends:
Complete 12 months of DAPT in patients who underwent PCI with either DES or BMS. (recommendation: 1a, LOE: A)
For patients who have complications such as bleeding, guidelines recommend that DAPT can be discontinued after 6 months.
For patients at low risk of bleeding, DAPT can be continued beyond 12 months. (recommendation: IIa)
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