SEPSISPAM Trial (2014): High versus low blood-pressure target in patients with septic shock
SEPSISPAM Trial Summary: Asfar P et al. randomized 776 patients ≥18 years with septic shock with sepsis defined by ≥2 SIRS criteria, likely or proven infection, and ≥1 organ with new dysfunction to either higher MAP goal (80-85 mmHg) or lower MAP goal (65-70 mmHg). The objective was to assess if goal MAP of 80-85 mmHg reduce all-cause mortality at 28 days when compared to a goal MAP of 65-70 mmHg in patients with septic shock. The results showed no difference in all-cause mortality or other outcomes with respect to both groups. The authors of the SEPSISPAM trial concluded that for patients with septic shock, a goal MAP of 80-85 mmHg does not reduce all-cause mortality at 28 days when compared to a goal of 65-70 mmHg.