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Gastroenterology

STOPAH Trial: Prednisolone or Pentoxifylline for Alcoholic Hepatitis

stopah trial on steroids in alcoholic hepatitis

The use of steroids vs Pentoxifylline in severe alcoholic hepatitis has long been debated. The STOPAH trial published in NEJM in 2015 was a strong 2×2 factorial design, randomized trial that established that neither pentoxifylline nor prednisolone provided significant survival benefit in patients with severe alcoholic hepatitis. Take a look at my visual abstract for the trial. You can use it free for educational purposes.