Calc Function

    • Calcs that help predict probability of a diseaseDiagnosis
    • Subcategory of 'Diagnosis' designed to be very sensitiveRule Out
    • Disease is diagnosed: prognosticate to guide treatmentPrognosis
    • Numerical inputs and outputsFormula
    • Med treatment and moreTreatment
    • Suggested protocolsAlgorithm





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    Patent Pending

    PACIFIC Trial (2017): Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC


    PACIFIC Trial visual abstract

    PACIFIC Trial Summary (NEJM 2018): Scott J et al. randomized 713 patients with stage III unresectable nonsmall cell lung cancer (NSCLC) who did not have disease progression after concurrent chemoradiotherapy were randomized to either Durvalumab 10mg/kg body weight twice weekly for 12 months (n=473) or matching placebo (n=236). The primary objective was to assess if Durvalumab prolongs survival and increases the time to death or prevent distant metastasis in patients with stage 3 unresectable nonsmall cell lung cancer. The primary outcome of 24-month overall survival rate was significantly higher in the Durvalumab group, 66.3% compared to 55.6% in the placebo group. The authors concluded that Durvalumab therapy resulted in significantly longer overall survival than placebo. No new safety signals were identified.

    Source: 2018, Durvalumab in non small cell lung cancer, NEJM