2017 INPRESS TRIAL Effect of individualized vs standard blood pressure management strategies on postoperative organ dysfunction among high-risk patients undergoing major surgery. Multicenter, randomized, parallel-group clinical trial Objective: To evaluate reduction in post-op organ dysfunction with Pan individualized BP management strategy as compared to standard practice in high-risk patients undergoing surgical procedures. 5 298 Inclusion criteria: Patients >50 years of age: – Undergoing surgery under GA for >2hrs – ASA score > – Pre-op AKI Risk Index of class 3 patients Individualized treatment group (n=149) Standard treatment group (n=149) PRIMARY OUTCOME 38.1 Composite of SIRS & at least 1 organ system dysfunction by post op day 7 % RR 0.73; 95% CI, 0.56 to 0.94; P= 0.02 51.7 SECONDARY OUTCOME 32.7 Renal dysfunction % RR 0.70; 95% CI, 0.5 to 0.92; P= 0.01 49.0 5.4 Altered Consciousness % RR 0.34; 95% CI, 0.16 to 0.75; P= 0.007 15.9 Conclusion: Management targeting an individualized systolic BP reduced the risk of post-op organ dysfunction compared with standard management. E Futier et al. JAMA 2017,318(14):1346-1357