ADAPT AF-DES Trial (2025) Therapy for Atrial Fibrillation in Patients with Drug-Eluting StentsMulticenter, randomized, open-label, noninferiority trial Objective:In patients with atrial fibrillation (AF) who previously underwent drug-eluting stent (DES) implantation, does NOAC monotherapy provide similar protection against ischemic and bleeding … Read More
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VESALIUS-CV Trial: Evolocumab in Patients without MI or Stroke
VESALIUS-CV Trial (2025) Evolocumab in Patients without a Previous Myocardial Infarction or StrokeInternational, double-blind, randomized, placebo-controlled trial Objective:Among patients with atherosclerosis or diabetes but no prior MI or stroke, does long-term PCSK9 inhibition with evolocumab reduce the risk of first … Read More
CORE-TIMI: Olezarsen to prevent Pancreatitis
Olezarsen for Managing Severe Hypertriglyceridemia and Pancreatitis RiskTwo double-blind, randomized, placebo-controlled phase 3 trials Objective:To evaluate whether olezarsen, an antisense oligonucleotide targeting apolipoprotein C-III mRNA, reduces triglyceride levels and pancreatitis risk in patients with severe hypertriglyceridemia (TG ≥ 500 mg/dL). … Read More
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