CREST-2 Trials (2025) Medical Management vs Revascularization for Asymptomatic Carotid StenosisTwo parallel, observer-blinded randomized clinical trials (Stenting + CEA) Objective:To determine whether adding carotid revascularization (stenting or endarterectomy) to intensive medical management provides additional benefit over medical therapy alone in … Read More
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ADAPT AF-DES: Therapy for AFib Patients with DES
ADAPT AF-DES Trial (2025) Therapy for Atrial Fibrillation in Patients with Drug-Eluting StentsMulticenter, randomized, open-label, noninferiority trial Objective:In patients with atrial fibrillation (AF) who previously underwent drug-eluting stent (DES) implantation, does NOAC monotherapy provide similar protection against ischemic and bleeding … Read More
VESALIUS-CV Trial: Evolocumab in Patients without MI or Stroke
VESALIUS-CV Trial (2025) Evolocumab in Patients without a Previous Myocardial Infarction or StrokeInternational, double-blind, randomized, placebo-controlled trial Objective:Among patients with atherosclerosis or diabetes but no prior MI or stroke, does long-term PCSK9 inhibition with evolocumab reduce the risk of first … Read More
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