FRISC II Trial Visual Summary

1999, Invasive compared with non-invasive treatment in unstable coronary-artery disease, The Lancet

The FRISC II trial established the role of early intervention in patients with UA/NSTEMI. The study compared maximal medical therapy or non invasive approach with intervention and showed significant decrease in the incidence of MI.

The combine MI and/or mortality was found to be significantly lower after 5 years in patients who underwent invasive approach compared with non invasive approach 19.9% vs. 24.5% (RR 0.81; 95% CI 0.69–0.95; P=0.009). The early vs late intervention question was later answered by the TIMACS trial.