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PANSAID Trial (2019): Paracetamol and Ibuprofen on Morphine Consumption in the Total Hip Arthroplasty


PANSAID Trial Summary: Hojgaard et al. randomized 556 patients who were scheduled to undergo total hip arthroplasty to pain control with a combination of paracetamol + ibuprofen or any one of them with placebo. The primary objective was to assess if post-op morphine requirement decreases with the use of adjunctive pain medications. The results showed significant decrease in morphine requirement when paracetamol and ibuprofen were used in combination full dose. Ibuprofen alone was also found to have signficant benefit in terms of decreasing the morphine requirement therefore, the authors concluded that isolated ibuprofen can be used as an adjunct pain medication to lessen the requirement of patient-controlled morphine in patients who undergo total hip arthroplasty.  

Source: JAMA

LESS: Epidural Glucocorticoid Injections for Spinal Stenosis


2014, epidural glucocorticoid + lidocaine vs lidocaine only injections for spinal stenosis, NEJM

PRECISION Trial: Cardiovascular safety of celecoxib, naproxen, or ibuprofen for arthritis

This visual abstract represents the important findings of the PRECISION trial. The trial compares the COX-2 selective NSAID celecoxib with traditionally used NSAIDs such as naproxen and ibuprofen. It establishes non inferiority in terms of cardiovascular events and superiority in terms of GI and renal safety. As of March 2017, no guidelines have been published that reflect the results of this trial.

Source: NEJM

SPACE Trial: Effect of Opioid vs Nonopioid Medications on Pain-Related Function

Source: JAMA

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