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ALIVE Trial: Amiodarone as Compared with Lidocaine for Shock-Resistant Ventricular Fibrillation

ALIVE trial

2002, ALIVE Trial Visual Summary: Amiodarone as Compared with Lidocaine for Shock-Resistant Ventricular Fibrillation. NEJM

ARREST Trial: Amiodarone for Resuscitation after Out-of-Hospital Cardiac Arrest Due to Ventricular Fibrillation

ARREST Trial: 1999, Amiodarone for Resuscitation after Out-of-Hospital Cardiac Arrest Due to Ventricular Fibrillation. NEJM

CRISTAL Trial (2013): Fluid Resuscitation with Colloids vs. Crystalloids in Hypovolemic Shock

Source: JAMA

PARAMEDIC2 Trial: Epinephrine in Out-of-Hospital Cardiac Arrest

The PARAMEDIC2 trial that was recently published in NEJM studied the use of epinephrine in the out-of-hospital cardiac arrest and compared the final outcome of survival with placebo. Patients who had a cardiac arrest out of hospital were treated with the standard resuscitation protocol. The patient population which was given epinephrine compared to placed were noted to have slightly better survival rates. Take a look at the visual abstract that is now published in ACC.

PAMPer Trial: Prehospital Plasma in Trauma Patients

pamper trial visual abstract on plasma use in trauma

PAMPer trial is a multicenter randomized trial that evaluated the use of thawed plasma in addition to standard resuscitation measures in patients at risk of subsequent hemorrhagic shock. The results showed a significant 30-day mortality benefit in patients who received plasma transfusion in addition to standard resuscitation while en route to a trauma center.

Source: NEJM

Basic Modes of Mechanical Ventilation Infographic

Mechanical ventilation is a complex topic to understand. With this infographic, I have tried to explain 4 most commonly used ventilator modes in intensive care units. The two broad categories are the volume limited and pressure limited ventilation while each of them have further sub-branches. In future posts, I’m going to create a basic flowchart of all ventilator modes with their benefits and disadvantages. Till then, use this infographic to understand the basic of mechanical ventilation and how pressure, flow and volumes are linked to each other.

Algorithm for Management of Adult Patients with DKA

Diabetic ketoacidosis requires emergent intervention and treatment. The treatment of DKA requires careful monitoring of both acidosis as well as blood glucose levels. In order to streamline the treatment process, I have designed the following algorithm keeping in mind the complexity of the disease. This management algorithm is based on the American Diabetes association updated guidelines of 2009. Feel free to print this and share it without colleagues and students.

ProACT Trial: Procalcitonin-Guided Antibiotics for Lower Respiratory Tract Infection

Procalcitonin has proven to be a great marker for guiding antibiotics treatment in patients with concern for lower respiratory tract infections. However, it’s not yet established how much does clinicians adhere to using the antibiotic therapy based on procalcitonin results. The ProACT trial recently got published in NEJM. It showed that despite it’s usefulness, clinicians still base their antibiotic use on clinical suspicion. Take a look at our visual abstract for the findings.

Undetectable High-Sensitivity Cardiac Troponin T Level in the Emergency Department and Risk of Myocardial Infarction

Source: JACC

PEITHO Trial: Fibrinolysis for patients with intermediate-risk pulmonary embolism

peitho trial studied the use of fibrinolytics in intermediate risk pulmonary embolism

Source: NEJM

ICON-RELOADED Study: N-Terminal Pro–B-Type Natriuretic Peptide in the Emergency Department

Source: JACC

PROPPR Trial: Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs 1:1:2 Ratio and Mortality in Patients With Severe Trauma

Source: JAMA

Contribution by Sagar Dave
PGY2, Emergency Medicine
UConn Health

ADJUST-PE study: Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism

Source: JAMA

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