Effectiveness and safety of 0•5% colchicine cream vs. photodynamic therapy with methyl aminolaevulinate in the treatment of actinic keratosis and skin field cancerization of the forearms: a randomized controlled trial
The objective of the study was to evaluate the effectiveness and safety of 0•5% colchicine (COL) cream vs. methyl
36 patients were included in the study. The sample size was calculated to detect a reduction difference of more than 10% between groups and SDs of equivalent differences. Inclusion criteria: outpatients attending a public dermatology clinic at UNESP Medical School (Botucatu‐SP, Brazil), over the age of 18 years, from both sexes, with a clinical diagnosis of AK on the forearms (3–10 lesions) and had not received treatment for AK (except for sunscreen) for at least 6 months.
In the COL group, whole forearms were treated with 0•5% COL cream twice daily for 10 days. In the MAL-PDT group,
The primary outcome was a reduction in AK count on the forearms 60 days after treatment. AK count was reduced in 45% of patients treated with COL and 40% of those treated with MAL‐PDT. P<0.01 for both groups, for a reduction in AK count. P = 0•56 between groups. AK count was compared according to time and to groups (over time) by a linear mixed effects model with robust covariance matrix and probability adjustment for each distribution. Post hoc analysis was performed using the sequential Sidak procedure.
The study concluded that a 10-day course of COL 0•5% cream and a single session of MAL‐PDT are safe and effective for treating skin field cancerization of the forearms. Side effects were minimal and similar between the groups.
Summarized by: Jonas A. Adalsteinsson, UConn Department of Dermatology