2009, Intensity of Continuous Renal-Replacement Therapy in Critically Ill Patients (RENAL), NEJM The RENAL trial was one of the largest trials that addressed an important question of doing continuous renal replacement therapy (CRRT) in critically ill patients with renal impairment. Based on this trial, high intensity CRRT at flow rate of 40 ml/kg/hr was found..
Category: Critical Care - page 2
2012, Intraaortic Balloon Support for Myocardial Infarction with Cardiogenic Shock, NEJM
ATHOS-3 Trial Summary: A total of 321 patients with vasodilatory shock on high dose catecholamines were randomized to angiotensin II or placebo. Within 3 hours, ~70% of in the angiotensin II group showed significant improvement in their mean arterial pressure as compared with 23.4% patients in placebo group (p<0.0001). Despite improvement in pressures, there was no signficant change in 28-days mortality among the two groups. The authors..
2018, Glucocorticoids in Septic Shock, NEJM
2012, Activated protein C (DrotAA) in Sepsis, NEJM
2017, Lung Recruitment and Titrated PEEP vs Low PEEP in ARDS, JAMA