Acute Coronary Syndrome

ACT 2011, Acetylcysteine in Coronary Angiography
ATLAS ACS-2 2012, Rivaroxaban in Acute Coronary Syndrome
CAST I 1991, Antiarrhythmics post-MI
CHAMPION PHOENIX 2013, Cangrelor vs Clopidogrel in PCI
COMMIT 2005, Metoprolol after acute MI
CURE 2001, Effects of Clopidogrel plus Aspirin in Patients with NSTEMI
EPHESUS 2003, Eplerenone in patients with LV dysfunction after MI
ESSENCE 1997, Enoxaparin vs Unfractionated Heparin for UA/NSTEMI
CULPRIT-SHOCK 2018, Culprit lesion vs multivessel PCI in ACS with cardiogenic shock
SCOT-HEART 2018, CTA vs standard care in preventing MI
SADHART 2002, Sertraline for depression after ACS
IMPROVE-IT 2015, Ezetimibe + statin in acute coronary syndrome (ACS)
ULTIMATE 2018, 2018, IVUS vs angiography-guided implantation of DES
FRISC II 2006, Invasive compared with non-invasive treatment in unstable coronary artery disease
IABP-SHOCK II 2012, Intraaortic Balloon Pump for Myocardial Infarction with Cardiogenic Shock
MADIT-II 2002, Prophylactic Implantation of a Defibrillator in Patients with Myocardial Infarction and Reduced Ejection Fraction
PLATO 2009, Ticagrelor versus clopidogrel in patients with acute coronary syndromes
TRITON-TIMI 38 2007, Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndromes
TIMACS 2009, Early versus Delayed Invasive  Intervention in Acute Coronary Syndromes
MIRACL 2001, Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes
SMART-DATE 2018, 6-month versus 12-month or longer DAPT after PCI in ACS
OAT 2006, Coronary Intervention for Persistent Occlusion after Myocardial Infarction
OASIS-5 2006, Comparison of fondaparinux and enoxaparin in acute coronary syndromes

Aortic Stenosis

PARTNER A 2011, Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients
SURTAVI 2017, Surgical AVR or TAVR in intermediate-risk patients

Atrial Fibrillation

AFFIRM 2002, Rate control vs Rhythm control in Atrial Fibrillation
ORBIT-AF Registry 2013, Aspirin and OAC in Atrial Fibrillation
ROCKET AF 2011, Rivaroxaban vs. warfarin in atrial fibrillation
ARISTOTLE 2011, Apixaban vs. warfarin in atrial fibrillation
RACE II 2010, Strict vs Lenient Control of Heart Rate in Atrial Fibrillation
PROTECT-AF 2009, Percutaneous Closure of LAA in atrial fibrillation
CABANA 2018, Catheter Ablation for Atrial Fibrillation
CASTLE-AF 2018, Catheter Ablation for Atrial Fibrillation with Heart Failure
EMBRACE 2014, Atrial fibrillation in patients with cryptogenic stroke

Cardiac Arrest

HACA 2002, Hypothermia in Cardiac Arrest
PARAMEDIC2 2018, Epinephrine in Out-of-Hospital Cardiac Arrest
TTM 2014, 33 vs. 36°C body temperature after cardiac arrest

Coronary Artery Disease

LIPID 1998, Pravastatin in patients with coronary heart disease
HOPE 2000, ACE inhibitors, ramipril in high cardiovascular risk patients
CHARISMA 2006, Aspirin + clopidogrel vs. aspirin for CVD prevention
COURAGE 2007, PCI for stable CAD
JUPITER 2008, Rosuvastatin for prevention of CV events
POISE 2008, Metoprolol succinate in patients undergoing surgery
SYNTAX 2009, PCI vs CABG in severe CAD
DAPT 2014, 12 or 30 months of dual antiplatelet therapy after drug-eluting stents PCI
COMPASS 2017, Rivaroxaban with or without ASA in stable CAD
MANAGE 2018, Dabigatran in myocardial injury after non-cardiac surgery
VITAL (Vitamin D) 2018, Vitamin D3 for prevention of CVD and cancer
VITAL (N3) 2018, N3 fatty acid supplements for prevention of CVD and cancer
REDUCE-IT 2018, Cardiovascular risk reduction with Icosapent ethyl for hypertriglyceridemia
FREEDOM 2012, Percutaneous Coronary Intervention (PCI) vs CABG in Patients with Diabetes and multivessel CAD
ASPREE 2018, Aspirin for Primary Prevention in Healthy Adults
ARRIVE 2018, Aspirin for Primary Prevention in Adults at Moderate Cardiovascular Risk
PIONEER AF-PCI 2016, Prevention of bleeding in patients with Atrial fibrillation undergoing PCI
EXCEL 2016, Everolimus-eluting stents or bypass surgery for left main coronary artery disease
ORBITA 2017, Percutaneous coronary intervention in stable angina
CIRT 2018, Low-dose methotrexate for the prevention of atherosclerotic events
EAGLES 2018, Cardiovascular Safety of Smoking Cessation Medications
FOURIER 2017, Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease
CANTOS 2017, Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
NORSTENT 2016, Drug-Eluting (DES) or Bare-Metal Stents (BMS) for Coronary Artery Disease
DIVA 2018, Drug-eluting stents versus bare-metal stents in saphenous vein grafts

Peripheral Arterial Disease

CREST 2010, Stenting versus CEA in Carotid-Artery Stenosis


SPYRAL HTN-ON MED 2018, Renal Denervation in Uncontrolled Hypertension
ALLHAT 2002, Antihypertensive drugs to prevent Heart Attack
Barber Cluster Trial 2018, Barbershop Interventions in Controlling Blood Pressure
Ambulatory BP and Mortality 2018, Ambulatory BP measurements and mortality
SPRINT 2015, Intensive Versus Standard Blood Pressure Control

Heart Failure

TOPCAT 2014, Spironolactone in HFpEF
COAPT 2018, Mitral valve repair in Patients with Heart failure
COMET 2003, Comparison of Carvedilol and Metoprolol in Chronic Heart Failure
DIG 1997, Digoxin in Heart failure with reduced ejection fraction
Ancillary DIG 2006, Digoxin in Heart failure with preserved ejection fraction
SURVIVE 2007, Levosimendan in acute decompensated heart failure
DOSE 2011, Furosemide in Acute Decompensated Heart Failure
PIONEER-HF 2018, Angiotensin-neprilysin inhibition in acute decompensated heart failure
PARADIGM-HF 2014, Angiotensin-neprilysin inhibition versus enalapril in heart failure
BLOCK HF 2013, Biventricular versus Right Ventricular Pacing in Heart Failure Patients with Atrioventricular Block
MITRA-FR 2018, Percutaneous Repair or Medical Treatment for Secondary Mitral Regurgitation
RALES 1999, The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
CORONA 2007, Rosuvastatin in Older Patients with Systolic Heart Failure


WARFASA 2012, Aspirin for Recurrent VTE
EINSTEIN-PE 2012, Rivaroxaban for Acute PE
AMPLIFY 2013, Apixaban for VTE
ANNEXA 2015, Andexanet for reversal of Factor Xa Inhibitors
ADJUST PE 2014, Age Adjusted D Dimer for PE
MOPETT 2013, Low-dose tPA for submassive PE
SOME 2015, Cancer screening in unprovoked VTE
AVERT 2018, Apixaban to Prevent Venous Thromboembolism (VTE) in Patients with Cancer


SPARCL 2006, High-dose atorvastatin after stroke or transient ischemic attack (TIA)
SOCRATES 2016, Ticagrelor versus aspirin in acute stroke or TIA
EXTEND-IA TNK 2018, Tenecteplase vs Alteplase in Ischemic Stroke
WAKE-UP 2018, MRI guided thrombolysis with alteplase in stroke with unknown time of onset
DEFUSE-3 2018, Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging
RESPECT 2013, Closure of Patent Foramen Ovale versus Medical Therapy after Cryptogenic Stroke
Gore REDUCE 2017, Patent Foramen Ovale Closure or Antiplatelet Therapy for Cryptogenic Stroke
CLOSURE I 2012, Closure or Medical Therapy for Cryptogenic Stroke with Patent Foramen Ovale

Ventricular Tachycardia

VANISH 2016, Ventricular Tachycardia Ablation versus Escalation of Antiarrhythmic Drugs

Infectious Disease


INSIGHT START 2015, INSIGHT START: Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection


Fidaxomicin in C. diff Infection 2011, Fidaxomicin versus vancomycin for Clostridium difficile infection
PRORATA 2010, Procalcitonin guided antibiotic therapy in critically ill patients
PROACT 2018, Procalcitonin in Lower Respiratory Tract Infections
POET 2018, IV vs PO Antibiotics in Infective Endocarditis
MERINO 2018, Piperacillin-Tazobactam vs Meropenem in Ceftriaxone resistant Infections
CAPSTONE-1 2018, Baloxavir Marboxil for Uncomplicated Influenza
STOP-IT 2015, Short-Course Antimicrobial Therapy for Intraabdominal Infection

Hepatitis C

DAHHS2 2019, Treatment of acute hepatitis C with 8 weeks of grazoprevir plus elbasvir
VALENCE 2014, Sofosbuvir and ribavirin in HCV


PROWESS-SHOCK 2012, Activated protein C (DrotAA) in Sepsis
TRISS 2014, Restrictive vs Liberal Transfusion in Septic Shock
ALBIOS 2014, Albumin in Severe Sepsis and Septic Shock
SALT-ED 2018, Balanced crystalloids versus saline in non-critically ill adults
ADRENAL 2018, Glucocorticoids in Septic Shock
APROCCHSS 2018, Hydrocortisone + Fludrocortisone in Septic Shock
BICAR-ICU 2018, Sodium Bicarbonate in Severe Metabolic Acidaemia



IDNT 2001, Irbesartan in diabetic nephropathy
RENAAL 2012, Losartan in diabetic nephropathy


IDEAL 2010, Early versus Late Dialysis in Patients with ESRD
AKIKI 2016, Renal Replacement Therapy in ICU
RENAL 2009, Intensity of Continuous Renal-Replacement Therapy in Critically Ill Patients



EMPA-REG OUTCOMES 2015, Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes
CANVAS 2017, Canagliflozin in Type II DM
ASCEND ASA 2018, Aspirin for primary prevention of CVD in DM
ASCEND N3 2018, N3 fatty acid supplements for primary prevention in DM
RABBIT2 2007, Basal-bolus insulin in inpatients with DM
Metformin in CKD Cohort 2018, Metformin in CKD
Closed Loop Insulin Trial 2018, Closed-loop Insulin Delivery in Non-ICU patients
ACCORD 2008, Effects of Intensive Glucose Lowering in Type 2 Diabetes
LEADER 2016, Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes


GI bleed

SUP-ICU 2018, Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU
POP-UP 2016, Pantoprazole or Placebo for Stress Ulcer Prophylaxis


Albumin in SBP 1999, IV albumin in patients with cirrhosis and SBP
Rifaxamin in HE 2013, Rifaxamin in hepatic encephalopathy
STOPAH 2015, Prednisolone in Alcoholic Hepatitis
Bezafibrate Trial 2018, Bezafibrate in Primary Biliary Cholangitis 

Pulmonology / Critical Care


EXTRA 2011, Omalizumab in Severe Allergic Asthma


REDUCE 2013, Short term steroids in COPD exacerbation


PROSEVA 2013, Prone Positioning in Severe Acute Respiratory Distress Syndrome (ARDS)
ART 2017, Lung Recruitment and Titrated PEEP vs Low PEEP in ARDS

Mechanical Ventilation

PReVENT 2018, Low vs Intermediate Tidal Volume Strategy in ICU Patients Without ARDS


ATHOS-3 2017, Angiotensin II for the Treatment of Vasodilatory Shock
CRISTAL 2013, Effects of fluid resuscitation with colloids vs. crystalloids on mortality in hypovolemic shock


PAMPer 2018, Prehospital Plasma in Trauma Patients
PROPPR 2015, Transfusion of Plasma, Platelets, and Red Blood Cells in Severe Trauma

Hematology / Oncology


COLONPREV 2012, FIT vs. colonoscopy for colon cancer screening
NELSON 2018, CT scan for screening lung cancer
AGE 2006, Mammographic screening from age 40 years
Metachronous Gastric Trial 2018, H-Pylori treatment in Metachronous Gastric Cancer
PACIFIC 2018, Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC
FREGAT 2019, Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer


CHOIR 2006, Erythropoetin for anemia in non-dialysis CKD


METEOR 2013, Surgery vs Physical Therapy for a Meniscal Tear and Osteoarthritis
BeSt 2005, DMARD with prednisone or infliximab in RA
LESS 2014, Epidural Glucocorticoid Injections for Spinal Stenosis