Cardiovascular Trials

TopicTrial Year/TitleSubject
AcetylcysteineACT2011, Acetylcysteine in Coronary AngiographyCardiorenal
Direct Xa InhibitorsATLAS ACS-22012, Rivaroxaban in Acute Coronary SyndromeAcute Coronary Syndrome
AntiarrhythmicsCAST I1991, Antiarrhythmics post-MIAcute Coronary Syndrome
Anti-platelet therapyCHAMPION PHOENIX2013, Cangrelor vs Clopidogrel in PCIAcute Coronary Syndrome
Beta blockersCOMMIT2005, Metoprolol after acute MIAcute Coronary Syndrome
Anti-platelet therapyCURE2001, Effects of Clopidogrel plus Aspirin in Patients with NSTEMIAcute Coronary Syndrome
Aldosterone AntagonistsEPHESUS2003, Eplerenone in patients with LV dysfunction after MIAcute Coronary Syndrome
HeparinoidsESSENCE1997, Enoxaparin vs Unfractionated Heparin for UA/NSTEMIAcute Coronary Syndrome
Cardiogenic ShockCULPRIT-SHOCK2018, Culprit lesion vs multivessel PCI in ACS with cardiogenic shockAcute Coronary Syndrome
CCTASCOT-HEART2018, CTA vs standard care in preventing MICardiac Imaging
AntidepressantsSADHART2002, Sertraline for depression after ACSAcute Coronary Syndrome
StatinsIMPROVE-IT2015, Ezetimibe + statin in acute coronary syndrome (ACS)Acute Coronary Syndrome
IVUSULTIMATE2018, IVUS vs angiography guided implantation of DESCardiac Imaging
PCIFRISC II2006, Invasive compared with non-invasive treatment in unstable coronary artery diseaseAcute Coronary Syndrome
Cardiogenic ShockIABP-SHOCK II2012, Intraaortic Balloon Pump for Myocardial Infarction with Cardiogenic ShockAcute Coronary Syndrome
DevicesMADIT-II2002, Prophylactic Implantation of a Defibrillator in Patients with Myocardial Infarction and Reduced Ejection FractionAcute Coronary Syndrome
Anti-platelet therapyPLATO2009, Ticagrelor versus clopidogrel in patients with acute coronary syndromesAcute Coronary Syndrome
Anti-platelet therapyTRITON-TIMI 382007, Prasugrel versus Clopidogrel in Patients with Acute Coronary SyndromesAcute Coronary Syndrome
PCITIMACS2009, Early versus Delayed Invasive  Intervention in Acute Coronary SyndromesAcute Coronary Syndrome
StatinsMIRACL2001, Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromesAcute Coronary Syndrome
PCISMART-DATE2018, 6-month versus 12-month or longer DAPT after PCI in ACSAcute Coronary Syndrome
PCIOAT2006, Coronary Intervention for Persistent Occlusion after Myocardial InfarctionAcute Coronary Syndrome
HeparinoidsOASIS-52006, Comparison of fondaparinux and enoxaparin in acute coronary syndromesAcute Coronary Syndrome
StatinsPROVE IT2004, Intensive versus Moderate Lipid Lowering with Statins after Acute Coronary SyndromesAcute Coronary Syndrome
ACE/ARBsVALIANT2003, Valsartan vs. captopril in patients with acute MI and HFAcute Coronary Syndrome
Direct Xa InhibitorsTRAPS2018, Rivaroxaban vs. warfarin in high-risk patients with antiphospholipid syndromeAntiphospholipid syndrome
TAVRPARTNER A2011, Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk PatientsValvular Heart Disease
TAVRSURTAVI2017, Surgical AVR or TAVR in intermediate-risk patientsValvular Heart Disease
TAVRPARTNER 22016, Transcatheter or Surgical Aortic Valve Replacement in Intermediate-Risk PatientsValvular Heart Disease
Direct Thrombin InhibitorsRE-ALIGN2013, Dabigatran versus warfarin in patients with mechanical heart valvesValvular Heart Disease
ErythropoetinCHOIR2006, Erythropoetin for anemia in non-dialysis CKDAnemia
TransfusionTRICC1999, Transfusion requirements in critical careAnemia
Atrial FibrillationAFFIRM2002, Rate control vs Rhythm control in Atrial FibrillationArrhythmia
Atrial FibrillationORBIT-AF Registry2013, Aspirin and OAC in Atrial FibrillationArrhythmia
Atrial FibrillationROCKET AF2011, Rivaroxaban vs. warfarin in atrial fibrillationArrhythmia
Atrial FibrillationARISTOTLE2011, Apixaban vs. warfarin in atrial fibrillationArrhythmia
Atrial FibrillationRACE II2010, Strict vs Lenient Control of Heart Rate in Atrial FibrillationArrhythmia
Atrial FibrillationPROTECT-AF2009, Percutaneous Closure of LAA in atrial fibrillationArrhythmia
Atrial FibrillationCABANA2018, Catheter Ablation for Atrial FibrillationArrhythmia
Atrial FibrillationCASTLE-AF2018, Catheter Ablation for Atrial Fibrillation with Heart FailureArrhythmia
Atrial FibrillationEMBRACE2014, Atrial fibrillation in patients with cryptogenic strokeArrhythmia
Atrial FibrillationCRYSTAL AF2014, Cryptogenic Stroke and Underlying Atrial FibrillationArrhythmia
Atrial FibrillationAATAC2016, Ablation vs. amiodarone for persistent atrial fibrillation in patients with CHFArrhythmia
Atrial FibrillationAF-CHF2008, Rhythm Control versus Rate Control for Atrial Fibrillation and Heart FailureArrhythmia
Atrial FibrillationENGAGE AF-TIMI 482013, Edoxaban versus warfarin in patients with atrial fibrillationArrhythmia
Atrial FibrillationBRIDGE2015, Perioperative Bridging Anticoagulation in Patients with Atrial FibrillationArrhythmia
HypothermiaHACA2002, Hypothermia in Cardiac ArrestCardiac Arrest
EpinephrinePARAMEDIC22018, Epinephrine in Out-of-Hospital Cardiac ArrestCardiac Arrest
HypothermiaTTM2014, 33 vs. 36°C body temperature after cardiac arrestCardiac Arrest
StatinsLIPID1998, Pravastatin in patients with coronary heart diseaseCoronary Artery Disease
ACE/ARBsHOPE2000, ACE inhibitors, ramipril in high cardiovascular risk patientsCoronary Artery Disease
Anti-platelet therapyCHARISMA2006, Aspirin + clopidogrel vs. aspirin for CVD preventionCoronary Artery Disease
PCICOURAGE2007, PCI for stable CADCoronary Artery Disease
StatinsJUPITER2008, Rosuvastatin for prevention of CV eventsDyslipidemia
Pre-opPOISE2008, Metoprolol succinate in patients undergoing surgeryCardiovascular Surgery
CABGSYNTAX2009, PCI vs CABG in severe CADCardiovascular Surgery
Anti-platelet therapyDAPT2014, 12 or 30 months of dual antiplatelet therapy after drug-eluting stents PCICoronary Artery Disease
Direct Xa InhibitorsCOMPASS2017, Rivaroxaban with or without ASA in stable CADCoronary Artery Disease
Direct Thrombin InhibitorsMANAGE2018, Dabigatran in myocardial injury after non-cardiac surgeryCoronary Artery Disease
PreventionVITAL (Vitamin D)2018, Vitamin D3 for prevention of CVD and cancerCoronary Artery Disease
PreventionVITAL (N3)2018, N3 fatty acid supplements for prevention of CVD and cancerCoronary Artery Disease
Icosapent EthylREDUCE-IT2018, Cardiovascular risk reduction with Icosapent ethyl for hypertriglyceridemiaDyslipidemia
CABGFREEDOM2012, Percutaneous Coronary Intervention (PCI) vs CABG in Patients with Diabetes and multivessel CADCardiovascular Surgery
PreventionASPREE2018, Aspirin for Primary Prevention in Healthy AdultsCoronary Artery Disease
PreventionARRIVE2018, Aspirin for Primary Prevention in Adults at Moderate Cardiovascular RiskCoronary Artery Disease
Atrial FibrillationPIONEER AF-PCI2016, Prevention of bleeding in patients with Atrial fibrillation undergoing PCIArrhythmia
CABGEXCEL2016, Everolimus-eluting stents or bypass surgery for left main coronary artery diseaseCardiovascular Surgery
PCIORBITA2017, Percutaneous coronary intervention in stable anginaCoronary Artery Disease
Antiinflammatory TherapyCIRT2018, Low-dose methotrexate for the prevention of atherosclerotic eventsCoronary Artery Disease
CV SafetyEAGLES2018, Cardiovascular Safety of Smoking Cessation MedicationsCoronary Artery Disease
PCSK9 InhibitorsFOURIER2017, Evolocumab and Clinical Outcomes in Patients with Cardiovascular DiseaseCoronary Artery Disease
Antiinflammatory TherapyCANTOS2017, Antiinflammatory Therapy with Canakinumab for Atherosclerotic DiseaseCoronary Artery Disease
PCINORSTENT2016, Drug-Eluting (DES) or Bare-Metal Stents (BMS) for Coronary Artery DiseaseCoronary Artery Disease
PCIDIVA2018, Drug-eluting stents versus bare-metal stents in saphenous vein graftsCoronary Artery Disease
FFRFAME2009, Fractional Flow Reserve versus Angiography for Guiding Percutaneous Coronary InterventionCoronary Artery Disease
FFRFAME 22012, Fractional flow reserve-guided PCI versus medical therapy in stable coronary diseaseCoronary Artery Disease
Anti-platelet therapyWOEST2013, Clopidogrel with or without aspirin in patients taking OAC and undergoing PCICoronary Artery Disease
Triple TherapyRE-DUAL PCI2017, Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial FibrillationCoronary Artery Disease
Triple TherapyISAR-TRIPLE2015, Duration of Triple Therapy in Patients Requiring OAC After DESCoronary Artery Disease
StatinsTNT2005, Intensive lipid lowering with atorvastatin in patients with Stable CADCoronary Artery Disease
CABGART – CABG2019, Bilateral versus Single Internal-Thoracic-Artery Grafts at 10 YearsCardiovascular Surgery
Carotid Artery StenosisCREST2010, Stenting versus CEA in Carotid-Artery StenosisPeripheral Vascular Disease
SGLT-2 InhibitorsEMPA-REG OUTCOMES2015, Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 DiabetesDiabetes
SGLT-2 InhibitorsCANVAS2017, Canagliflozin in Type II DMDiabetes
PreventionASCEND ASA2018, Aspirin for primary prevention of CVD in DMDiabetes
PreventionASCEND N32018, N3 fatty acid supplements for primary prevention in DMDiabetes
InsulinRABBIT22007, Basal-bolus insulin in inpatients with DMDiabetes
MetforminMetformin in CKD Cohort2018, Metformin in CKDDiabetes
InsulinClosed Loop Insulin Trial2018, Closed-loop Insulin Delivery in Non-ICU patientsDiabetes
StatinsACCORD2008, Effects of Intensive Glucose Lowering in Type 2 DiabetesDiabetes
GLP-1 AgonistsLEADER2016, Liraglutide and Cardiovascular Outcomes in Type 2 DiabetesDiabetes
SGLT-2 InhibitorsDECLARE-TIMI 582019, Dapagliflozin and Cardiovascular Outcomes in Type 2 DiabetesDiabetes
TransfusionTransfusion in UGIB2013, Transfusion Strategies for Acute Upper Gastrointestinal BleedingAnemia
ManagementSPYRAL HTN-ON MED2018, Renal Denervation in Uncontrolled HypertensionHypertension
ManagementALLHAT2002, Antihypertensive drugs to prevent Heart AttackHypertension
ManagementBarber Cluster Trial2018, Barbershop Interventions in Controlling Blood PressureHypertension
ScreeningAmbulatory BP and Mortality2018, Ambulatory BP measurements and mortalityHypertension
ManagementSPRINT2015, Intensive Versus Standard Blood Pressure ControlHypertension
ManagementSPRINT MIND2019, Effect of Intensive vs Standard Blood Pressure Control on Probable DementiaHypertension
Aldosterone AntagonistsTOPCAT2014, Spironolactone in HFpEFHeart Failure
Mitral Valve RepairCOAPT2018, Mitral valve repair in Patients with Heart failureValvular Heart Disease
Beta blockersCOMET2003, Comparison of Carvedilol and Metoprolol in Chronic Heart FailureHeart Failure
DigoxinDIG1997, Digoxin in Heart failure with reduced ejection fractionHeart Failure
DigoxinAncillary DIG2006, Digoxin in Heart failure with preserved ejection fractionHeart Failure
LevosimendanSURVIVE2007, Levosimendan in acute decompensated heart failureHeart Failure
DiureticsDOSE2011, Furosemide in Acute Decompensated Heart FailureHeart Failure
Angiotensin-neprilysin inhibitorsPIONEER-HF2018, Angiotensin-neprilysin inhibition in acute decompensated heart failureHeart Failure
Angiotensin-neprilysin inhibitorsPARADIGM-HF2014, Angiotensin-neprilysin inhibition versus enalapril in heart failureHeart Failure
DevicesBLOCK HF2013, Biventricular versus Right Ventricular Pacing in Heart Failure Patients with Atrioventricular BlockHeart Failure
Mitral Valve RepairMITRA-FR2018, Percutaneous Repair or Medical Treatment for Secondary Mitral RegurgitationValvular Heart Disease
Aldosterone AntagonistsRALES1999, The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart FailureHeart Failure
StatinsCORONA2007, Rosuvastatin in Older Patients with Systolic Heart FailureHeart Failure
DevicesDEFINITE2004, Prophylactic Defibrillator Implantation in Patients with Nonischemic Dilated CardiomyopathyHeart Failure
DevicesMOMENTUM 32018, Magnetically Levitated Cardiac Pump in Heart FailureHeart Failure
ACE/ARBsTRED-HF2019, Withdrawal of treatment for HF in patients with recovered DCMHeart Failure
Direct Xa InhibitorsCOMMANDER HF2018, Rivaroxaban in Patients with Heart Failure, Sinus Rhythm, and Coronary DiseaseHeart Failure
ACE/ARBsCONSENSUS1987, Effects of Enalapril on Mortality in Severe Congestive Heart FailureHeart Failure
ACE/ARBsSOLVD1991, Enalapril for Survival in Patients with Congestive Heart FailureHeart Failure
EndocarditisPOET2018, IV vs PO Antibiotics in Infective EndocarditisInfections
ACE/ARBsIDNT2001, Irbesartan in diabetic nephropathyDiabetes
ACE/ARBsRENAAL2001, Losartan in diabetic nephropathyDiabetes
Anti-platelet therapyEUCLID2017, Ticagrelor versus Clopidogrel in Symptomatic Peripheral Artery DiseasePeripheral Vascular Disease
StatinsSPARCL2006, High-dose atorvastatin after stroke or transient ischemic attack (TIA)Stroke
Anti-platelet therapySOCRATES2016, Ticagrelor versus aspirin in acute stroke or TIAStroke
ThrombolysisEXTEND-IA TNK2018, Tenecteplase vs Alteplase in Ischemic StrokeStroke
ThrombolysisWAKE-UP2018, MRI guided thrombolysis with alteplase in stroke with unknown time of onsetStroke
ThrombectomyDEFUSE-32018, Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion ImagingStroke
PFO ClosureRESPECT2013, Closure of Patent Foramen Ovale versus Medical Therapy after Cryptogenic StrokeStroke
PFO ClosureGore REDUCE2017, Patent Foramen Ovale Closure or Antiplatelet Therapy for Cryptogenic StrokeStroke
PFO ClosureCLOSURE I2012, Closure or Medical Therapy for Cryptogenic Stroke with Patent Foramen OvaleStroke
ThrombectomyDAWN2018, Mechanical Thrombectomy 6 to 24 Hours after StrokeStroke
Anti-platelet therapyPOINT2018, Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIAStroke
Atrial FibrillationBRIDGE2015, Perioperative Bridging Anticoagulation in Patients with Atrial FibrillationArrhythmia
Anti-platelet therapyCHANCE2013, Clopidogrel with aspirin in acute minor stroke or transient ischemic attackStroke
ManagementATHOS-32017, Angiotensin II for the Treatment of Vasodilatory ShockShock
ManagementCRISTAL2013, Effects of fluid resuscitation with colloids vs. crystalloids on mortality in hypovolemic shockShock
ResuscitationPAMPer2018, Prehospital Plasma in Trauma PatientsTrauma
ResuscitationPROPPR2015, Transfusion of Plasma, Platelets, and Red Blood Cells in Severe TraumaTrauma
Anti-platelet therapyWARFASA2012, Aspirin for Recurrent VTEVenous Thromboembolism
Direct Xa InhibitorsEINSTEIN PE2012, Rivaroxaban for Acute PEVenous Thromboembolism
Direct Xa InhibitorsAMPLIFY2013, Apixaban for VTEVenous Thromboembolism
Direct Xa InhibitorsANNEXA2015, Andexanet for reversal of Factor Xa InhibitorsVenous Thromboembolism
Pulmonary EmbolismADJUST PE2014, Age Adjusted D Dimer for PEVenous Thromboembolism
Pulmonary EmbolismMOPETT2013, Low-dose tPA for submassive PEVenous Thromboembolism
ScreeningSOME2015, Cancer screening in unprovoked VTEVenous Thromboembolism
Direct Xa InhibitorsAVERT2018, Apixaban to Prevent Venous Thromboembolism (VTE) in Patients with CancerVenous Thromboembolism
HeparinoidsCLOT2003, LMWH vs a coumarin for the prevention of recurrent VTE in patients with cancerVenous Thromboembolism
Direct Xa InhibitorsSELECT-D2018, Rivaroxaban vs LMWH (Dalteparin) in Patients With Cancer With VTEVenous Thromboembolism
Direct Xa InhibitorsHokusai VTE Cancer2018, Edoxaban for the Treatment of Cancer-Associated Venous ThromboembolismVenous Thromboembolism
HeparinoidsMEDENOX1999, Enoxaparin for Prevention of VTE in Acutely Ill Medical PatientsVenous Thromboembolism
Direct Xa InhibitorsMARINER2018, Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical IllnessVenous Thromboembolism
Ventricular TachycardiaVANISH2016, Ventricular Tachycardia Ablation versus Escalation of Antiarrhythmic DrugsArrhythmia
UltrafiltrationCARRESS HF2012, Ultrafiltration in Decompensated Heart Failure with Cardiorenal SyndromeCardiorenal
Beta blockersMERIT-HF1999, Effect of metoprolol CR/XL in chronic heart failureHeart Failure
Anti-platelet therapyCAPRIE1996, Clopidogrel versus aspirin in patients at risk of ischemic eventsCoronary Artery Disease
TAVRPARTNER 32019, Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk PatientsValvular Heart Disease
TAVREvolut Low Risk2019, TAVR with self-expanding valve in low risk patientsValvular Heart Disease
Mitral Valve RepairCOAPT-QoL2019, Health Status After TMVR in Patients With Heart Failure and Secondary Mitral RegurgitationValvular Heart Disease
DevicesWRAP-IT2019, Antibacterial Envelope to Prevent Cardiac Implantable Device InfectionInfections
Atrial FibrillationAUGUSTUS2019, Antithrombotic Therapy or PCI in Atrial FibrillationArrhythmia
ObesityCAMELLIA-TIMI 612019, Cardiovascular Safety of Lorcaserin in Overweight or Obese PatientsCardiometabolic disease
PreventionPREVENT2019, Adjunctive Intermittent Pneumatic Compression for Venous ThromboprophylaxisVenous Thromboembolism
InterventionCOACT2019, Coronary Angiography after Cardiac Arrest without ST-Segment ElevationCardiac Arrest
CABGMYRIAD2019, Volatile Anesthetics versus Total Intravenous Anesthesia for Cardiac SurgeryCardiovascular Surgery
Atrial FibrillationRACE 7 ACWAS2019, Early or Delayed Cardioversion in Recent-Onset Atrial FibrillationArrhythmia
NutritionTARGET2018, Energy-Dense versus Routine Enteral Nutrition in the Critically IllCardiometabolic disease
ManagementCREOLE2019, Comparison of Dual Therapies for Lowering Blood Pressure in Black AfricansHypertension
Bempedoic acidCLEAR Harmony2019, Safety and Efficacy of Bempedoic Acid to Reduce LDL CholesterolDyslipidemia
HypothermiaHypothermia in Cardiac Arrest2002, Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced HypothermiaCardiac Arrest
InsulinNICE-SUGAR2009, Intensive versus Conventional Glucose Control in Critically Ill PatientsDiabetes
SGLT-2 InhibitorsCREDENCE2019, Canagliflozin and Renal Outcomes in Type 2 Diabetes and NephropathyDiabetes
Anti-platelet therapySMART-CHOICE2019, P2Y12 Inhibitor Monotherapy vs. Dual Antiplatelet Therapy in Patients Undergoing PCICoronary Artery Disease
Atrial FibrillationALCOHOL-AF2019, Impact of Alcohol Abstinence in Moderate Drinkers With Atrial FibrillationArrhythmia
PCSK9 InhibitorsODYSSEY OUTCOMES2018, Alirocumab and Cardiovascular Outcomes after Acute Coronary SyndromeAcute Coronary Syndrome
PCIRESET2012, 3-Month Dual Antiplatelet Therapy Following Zotarolimus-Eluting Stent ImplantationCoronary Artery Disease
AnacetrapibHPS3/TIMI55-REVEAL2017, Effects of Anacetrapib in Patients with Atherosclerotic Vascular DiseaseDyslipidemia
PCISTOPDAPT-22019, One-Month vs. Standard 12-Month DAPT After Drug-Eluting Stent Implantation Coronary Artery Disease
PCISAFARI-STEMI2019, Safety and Efficacy of Femoral Access vs Radial Access in Patients with STEMIAcute Coronary Syndrome
ManagementADVANCE2008, Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 DiabetesDiabetes
Direct Xa InhibitorsCASSINI2019, Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with CancerVenous Thromboembolism
Anti-platelet therapyEPCAT I2013, Aspirin Versus LMWH for Extended VTE Prophylaxis After Total Hip ArthroplastyVenous Thromboembolism
Direct Xa InhibitorsEPCAT II2018, Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee ArthroplastyVenous Thromboembolism
HeparinoidsEPCAT I2013, Aspirin Versus LMWH for Extended VTE Prophylaxis After Total Hip ArthroplastyVenous Thromboembolism
Direct Xa InhibitorsEPCAT II2018, Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee ArthroplastyVenous Thromboembolism
StatinsAURORA2009, Rosuvastatin and Cardiovascular Events in Patients Undergoing HemodialysisDyslipidemia
CV SafetyEVOLVE2012, Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing DialysisCoronary Artery Disease
ACE/ARBsOCTAVE2004, Omapatrilat and enalapril in patients with hypertensionHypertension
ACE/ARBsEUROPA2003, Efficacy of perindopril in reduction of CV events among patients with stable CADCoronary Artery Disease
ErythropoetinTREAT2009, Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney DiseaseAnemia
HemorrhageCRASH-22010, Effects of tranexamic acid in trauma patients with significant haemorrhageTrauma
ErythropoetinRED-HF2013, Treatment of Anemia with Darbepoetin Alfa in Systolic Heart FailureAnemia
ErythropoetinRED-HF2013, Treatment of Anemia with Darbepoetin Alfa in Systolic Heart FailureHeart Failure
CraniectomyRESCUEicp2016, Decompressive Craniectomy for Traumatic Intracranial HypertensionHypertension
ACE/ARBsSONAR2019, Atrasentan and renal events in patients with type 2 diabetes and chronic kidney diseaseDiabetes
Gastric Bypass SurgerySTAMPEDE2012, Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with DiabetesDiabetes
ThrombolysisEXTEND2019, Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of StrokeStroke
Direct Xa InhibitorsMAGELLAN2013, Rivaroxaban for Thromboprophylaxis in Acutely Ill Medical PatientsVenous Thromboembolism
Direct Thrombin InhibitorsRE-SPECT ESUS2019, Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined SourceStroke
Direct Xa InhibitorsNAVIGATE ESUS2018, Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined SourceStroke
ManagementVADT2009, Glucose Control and Vascular Complications in Veterans with Type 2 DiabetesDiabetes
CV SafetyASCENT-COPD2019, Effect of Aclidinium Bromide on Major CV Events and Exacerbations in Patients With COPDCoronary Artery Disease
Anti-platelet therapyTROPICAL-ACS2017, Guided de-escalation of antiplatelet treatment in patients with ACS undergoing PCIAcute Coronary Syndrome
MetforminMET-REMODEL2019, Effect of metformin on left ventricular hypertrophy in patients with CAD without diabetesCoronary Artery Disease
DevicesREMATCH2001, Long-Term Use of a Left Ventricular Assist Device for End-Stage Heart FailureHeart Failure
Ventricular FibrillationALIVE2002, Amiodarone as Compared with Lidocaine for Shock-Resistant Ventricular FibrillationArrhythmia
AntiarrhythmicsARREST1999, Amiodarone for Resuscitation after Out-of-Hospital Cardiac Arrest Due to Ventricular FibrillationCardiac Arrest
Ventricular FibrillationARREST1999, Amiodarone for Resuscitation after Out-of-Hospital Cardiac Arrest Due to Ventricular FibrillationArrhythmia
Beta blockersCAPRICORN2001, Effect of carvedilol on outcome after MI in patients with LV dysfunctionAcute Coronary Syndrome
IronFAIR-HF2009, Ferric Carboxymaltose in Patients with Heart Failure and Iron DeficiencyHeart Failure
DevicesVEST2018, Wearable cardioverter-defibrillator after myocardial infarctionAcute Coronary Syndrome
Beta blockersCECCY2018, Carvedilol for Prevention of Chemotherapy-Related CardiotoxicityCardio-oncology
Abdominal Aortic AneurysmOVER2019, Open versus Endovascular Repair of Abdominal Aortic AneurysmCardiovascular Surgery
Abdominal Aortic AneurysmEVAR-12010, Endovascular versus Open Repair of Abdominal Aortic AneurysmCardiovascular Surgery
CTODECISION-CTO2019, Percutaneous Coronary Intervention for the Treatment of Chronic Total OcclusionCoronary Artery Disease
PCIDECISION-CTO2019, Percutaneous Coronary Intervention for the Treatment of Chronic Total OcclusionCoronary Artery Disease
DevicesRM-ALONE2019, Protocol for Pacemaker and Defibrillator Surveillance Based on Remote Monitoring OnlyArrhythmia
ThrombolysisATTRACT2017, Pharmacomechanical Catheter-Directed Thrombolysis for Deep-Vein ThrombosisVenous Thromboembolism
Lifestyle InterventionsDPP2002, Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or MetforminDiabetes
GLP-1 AgonistsPIONEER 62019, Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 DiabetesDiabetes
CABGTiCAB2019, Ticagrelor vs. aspirin in patients after coronary artery bypass graftingCardiovascular Surgery
Anti-platelet therapyTREAT2019, Ticagrelor Versus Clopidogrel in Patients With STEMI Treated With FibrinolysisAcute Coronary Syndrome
Pre-opCARP2004, Coronary-Artery Revascularization before Elective Major Vascular SurgeryCardiovascular Surgery
NiacinHPS2-THRIVE2014, Effects of Extended-Release Niacin with Laropiprant in High-Risk PatientsDyslipidemia
VasodilatorsRELAX2013, Effect of Sildenafil on Exercise Capacity and Clinical Status in HFpEFHeart Failure
DevicesRAFT2010, Cardiac-Resynchronization Therapy for Mild-to-Moderate Heart FailureHeart Failure
Atrial FibrillationFIRE AND ICE2016, Cryoballoon or Radiofrequency Ablation for Paroxysmal Atrial FibrillationArrhythmia
StatinsASSORT2017, Early Versus Delayed Statin Therapy in Patients With Acute Ischemic StrokeStroke
IVC FiltersPREPIC1998, Vena Caval Filters in Prevention of Pulmonary Embolism in Patients with Proximal Deep-Vein ThrombosisVenous Thromboembolism
CCTACONSERVE2019, Selective Referral Using CCTA Versus Direct Referral for Individuals Referred to Invasive Coronary Angiography for Suspected CADCardiac Imaging
PCICOMFORTABLE AMI2012, Effect of Biolimus-Eluting Stents With Biodegradable Polymer vs Bare-Metal Stents on Cardiovascular Events Among Patients With STEMIAcute Coronary Syndrome
NutritionEFFORT2019, Individualised nutritional support in medical inpatients at nutritional riskCardiometabolic disease
GLP-1 AgonistsREWIND2019, Dulaglutide and cardiovascular outcomes in type 2 diabetesDiabetes
ACE/ARBsVA NEPHRON-D2013, Combined angiotensin inhibition for the treatment of diabetic nephropathyDiabetes
CABGSTICH2011, Coronary-Artery Bypass Surgery in Patients with Left Ventricular DysfunctionHeart Failure
Pre-opPOISE-22014, Aspirin in Patients Undergoing Noncardiac SurgeryCardiovascular Surgery
CCTAPROMISE2015, Outcomes of Anatomical versus Functional Testing for Coronary Artery DiseaseCardiac Imaging
Anti-platelet therapyTHEMIS-PCI2019, Ticagrelor in patients with diabetes and stable CAD with a history of previous PCICoronary Artery Disease
Anti-platelet therapyTHEMIS2019, Ticagrelor in Patients with Stable Coronary Disease and DiabetesDiabetes
PCICOMPLETE2019, Complete Revascularization with Multivessel PCI for Myocardial InfarctionAcute Coronary Syndrome
Angiotensin-neprilysin inhibitorsPARAGON-HF2019, Angiotensin–Neprilysin Inhibition in Heart Failure with Preserved Ejection FractionHeart Failure
Anti-platelet therapyISAR-REACT 52019, Ticagrelor or Prasugrel in Patients with Acute Coronary SyndromesAcute Coronary Syndrome
Aldosterone AntagonistsEMPHASIS-HF2011, Eplerenone in Patients with Systolic Heart Failure and Mild SymptomsHeart Failure
TroponinsRAPID-TnT2019, Rapid Assessment of Possible ACS in the Emergency Department With High-Sensitivity Troponin TAcute Coronary Syndrome
SGLT-2 InhibitorsDAPA-HF2019, Dapagliflozin in Patients With Heart Failure and Reduced Ejection FractionHeart Failure
CABGNOBLE2016, Percutaneous coronary angioplasty versus coronary artery bypass grafting in treatment of unprotected left main stenosisCardiovascular Surgery
FFRMR-INFORM2019, Magnetic Resonance Perfusion or Fractional Flow Reserve in Coronary DiseaseCoronary Artery Disease
Pulmonary EmbolismPREPIC 22015, Effect of a Retrievable IVC Filter + Anticoagulation vs Anticoagulation Alone on Risk of Recurrent Pulmonary EmbolismVenous Thromboembolism
Pulmonary EmbolismPEITHO2014, Fibrinolysis for Patients with Intermediate-Risk Pulmonary EmbolismVenous Thromboembolism
NitratesA-HeFT2004, Combination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart FailureHeart Failure
PCITWILIGHT2019, Ticagrelor with or without Aspirin in High-Risk Patients after PCICoronary Artery Disease
Lifestyle InterventionsLook AHEAD2013, Cardiovascular Effects of Intensive Lifestyle Intervention in Type 2 DiabetesDiabetes
AmyloidosisATTR-ACT2018, Tafamidis Treatment for Patients with Transthyretin Amyloid CardiomyopathyInfiltrative Cardiomyopathies
HypothermiaHYPERION2019, Targeted Temperature Management for Cardiac Arrest with Nonshockable RhythmCardiac Arrest
Anti-platelet therapyCOGENT2010, Clopidogrel with or without Omeprazole in Coronary Artery Disease Coronary Artery Disease
Beta blockersCOPERNICUS2002, Effect of Carvedilol on the Morbidity of Patients With Severe Chronic Heart FailureHeart Failure
ManagementACCORD BP2010, Effects of Intensive Blood-Pressure Control in Type 2 Diabetes MellitusHypertension
EndocarditisEASE2012, Early Surgery versus Conventional Treatment for Infective EndocarditisInfections
DPP-4 InhibitorsSAVOR-TIMI2013, Saxagliptin and Cardiovascular Outcomes in Patients with Type 2 Diabetes MellitusDiabetes
DPP-4 InhibitorsTECOS2015, Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 DiabetesDiabetes
NiacinAIM HIGH2011, Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin TherapyDyslipidemia
Atrial FibrillationAVERROES2011, Apixaban in Patients with Atrial FibrillationArrhythmia
ManagementHYVET2008, Treatment of Hypertension in Patients 80 Years of Age or OlderHypertension
PCIGLOBAL LEADERS2018, Ticagrelor plus aspirin for 1 month, followed by ticagrelor monotherapy for 23 months vs standard DAPT after PCI with DESCoronary Artery Disease
Atrial FibrillationACTIVE A2009, Effect of Clopidogrel Added to Aspirin in Patients with Atrial FibrillationArrhythmia
Atrial FibrillationACTIVE W2006, Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillationArrhythmia
ThrombolysisECASS III2008, Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic StrokeStroke
Supraventricular tachycardiaREVERT2015, Postural modification to the standard Valsalva manoeuvre for emergency treatment of supraventricular tachycardiasArrhythmia
Renal Artery StenosisCORAL2014, Stenting and Medical Therapy for Atherosclerotic Renal-Artery StenosisPeripheral Vascular Disease
PCIDANAMI-3 PRIMULTI2015, Complete revascularisation versus culprit lesion only PCI in STEMI and multivessel diseaseAcute Coronary Syndrome
Antiinflammatory TherapyCOLCOT2019, Efficacy and Safety of Low-Dose Colchicine after Myocardial InfarctionAcute Coronary Syndrome
PCIISCHEMIA2019, International Study of Comparative Health Effectiveness With Medical and Invasive ApproachesCoronary Artery Disease
Surgical AVRRECOVERY2019, Early Surgery or Conservative Care for Asymptomatic Aortic StenosisValvular Heart Disease
TAVRGALILEO2019, Rivaroxaban after Transcatheter Aortic-Valve ReplacementValvular Heart Disease
Icosapent EthylREDUCE-IT USA2019, Reduction of Cardiovascular Events With Icosapent Ethyl in USA cohortDyslipidemia
PCIAIDA2017, Bioresorbable Scaffolds versus Metallic Stents in Routine PCICoronary Artery Disease
StatinsTreat Stroke to Target2019, A Comparison of Two LDL Cholesterol Targets after Ischemic StrokeStroke
DevicesDAVID2002, Dual-Chamber Pacing or Ventricular Backup Pacing in Patients With an Implantable DefibrillatorArrhythmia
PCIPRAMI2013, Randomized trial of preventative angioplasty in myocardial infarctionAcute Coronary Syndrome
DevicesDANISH2016, Defibrillator Implantation in Patients with Nonischemic Systolic Heart FailureHeart Failure
DevicesHEARTMATE II2009, Advanced Heart Failure Treated with Continuous-Flow Left Ventricular Assist DeviceHeart Failure
DevicesCARE-HF2005, The Effect of Cardiac Resynchronization on Morbidity and Mortality in Heart FailureHeart Failure
DevicesMIRACLE2002, Cardiac Resynchronization in Chronic Heart FailureHeart Failure
ThiazolidinedionesRECORD2009, Rosiglitazone for CV outcomes in oral agent combination therapy for type 2 diabetesDiabetes
Direct Thrombin InhibitorsMATRIX2015, Bivalirudin or Unfractionated Heparin in Acute Coronary SyndromesAcute Coronary Syndrome
PCIMATRIX2015, Radial versus femoral access in patients with acute coronary syndromesAcute Coronary Syndrome
StatinsWOSCOPS1995, Prevention of Coronary Heart Disease with Pravastatin in Men with HypercholesterolemiaDyslipidemia
Anti-platelet therapyPEGASUS-TIMI 542015, Long-Term Use of Ticagrelor in Patients with Prior Myocardial InfarctionAcute Coronary Syndrome
StatinsCLEAR Wisdom2019, Efficacy and Safety of Bempedoic Acid Added to Statins in Patients With Hypercholesterolemia and High CV RiskDyslipidemia
PCICvLPRIT2015. Complete versus lesion-only revascularization in patients undergoing primary PCI for STEMI and multivessel diseaseAcute Coronary Syndrome
Direct Thrombin InhibitorsRE-COVER2009, Dabigatran versus Warfarin in the Treatment of Acute Venous ThromboembolismVenous Thromboembolism
Atrial FibrillationAlcohol Abstinence 2020, Alcohol Abstinence in Drinkers with Atrial FibrillationArrhythmia
Cerebral Venous ThrombosisRE-SPECT CVT2019, Dabigatran Etexilate vs Dose-Adjusted Warfarin in Patients With Cerebral Venous ThrombosisVenous Thromboembolism
PCITRANSIENT2019, Timing of revascularization in patients with transient STEMIAcute Coronary Syndrome
ACE/ARBsACCOMPLISH2008, Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension in High-Risk PatientsHypertension
InclisiranORION-92019, Inclisiran for Heterozygous Familial HypercholesterolemiaDyslipidemia
ACE/ARBsCONSENSUS II1992, Effects of the Early Administration of Enalapril on Mortality in Patients with Acute MIAcute Coronary Syndrome
NesiritideASCEND-HF2011, Effect of Nesiritide in Patients with Acute Decompensated Heart FailureHeart Failure
OSASAVE2016, CPAP for Prevention of Cardiovascular Events in Obstructive Sleep ApneaCardio-Pulmonary Disease
COPDBLOCK COPD2019, Metoprolol for the Prevention of Acute Exacerbations of COPDCardio-Pulmonary Disease
PCICADILLAC2002, Angioplasty with Stenting, with or without Abciximab, in Acute Myocardial InfarctionAcute Coronary Syndrome
CABGEXCEL (5 Years)2019, Five-Year Outcomes after PCI or CABG for Left Main Coronary DiseaseCardiovascular Surgery
Atrial FibrillationAFIRE2019, Antithrombotic Therapy for Atrial Fibrillation with Stable Coronary DiseaseArrhythmia
Direct Xa InhibitorsAFIRE2019, Antithrombotic Therapy for Atrial Fibrillation with Stable Coronary DiseaseCoronary Artery Disease
VasodilatorsRELAX-AHF-22019, Effects of Serelaxin in Patients with Acute Heart FailureHeart Failure
AcetylcysteinePRESERVE2018, Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine Cardiorenal
GLP-1 AgonistsEXSCEL2017, Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 DiabetesDiabetes
PFO ClosureCLOSE2017, Patent Foramen Ovale Closure or Anticoagulation vs. Antiplatelets after StrokeStroke
Cardiogenic ShockSHOCK1999, Early Revascularization in Acute Myocardial Infarction Complicated by Cardiogenic ShockAcute Coronary Syndrome
Angiotensin-neprilysin inhibitorsEVALUATE-HF2019, Sacubitril-Valsartan vs Enalapril on Aortic Stiffness in Patients with HFrEFHeart Failure
FFRDEFINE-FLAIR2017, Use of the Instantaneous Wave-free Ratio or Fractional Flow Reserve in PCICoronary Artery Disease
iFRDEFINE-FLAIR2017, Use of the Instantaneous Wave-free Ratio or Fractional Flow Reserve in PCICoronary Artery Disease
FFRFAMOUS-NSTEMI2014, Fractional flow reserve vs. angiography in guiding management to optimize outcomes in NSTEMIAcute Coronary Syndrome
FFRCOMPARE-ACUTE2017, Fractional Flow Reserve Guided-Multivessel Angioplasty in Myocardial InfarctionAcute Coronary Syndrome
iFRiFR-SWEDEHEART2017, Instantaneous Wave-free Ratio versus Fractional Flow Reserve to Guide PCICoronary Artery Disease
FFRiFR-SWEDEHEART2017, Instantaneous Wave-free Ratio versus Fractional Flow Reserve to Guide PCICoronary Artery Disease
TransfusionTRICS III2018, Six-Month Outcomes after Restrictive or Liberal Transfusion for Cardiac SurgeryCardiovascular Surgery
Atrial FibrillationRAFF22020, Electrical vs. Pharmacological Cardioversion for ED Patients With Acute AFArrhythmia