API-CAT Trial: Evaluating Low-Dose Apixaban for Cancer-Associated Thrombosis Introduction The API-CAT trial is a groundbreaking study designed to evaluate whether a reduced dose of apixaban (2.5 mg twice daily) is as effective as the standard full-dose regimen (5 mg twice … Read More
Clinical Trials at your Fingertips!
Revolutionizing Medical Reference with Quick, Accessible Summaries of Landmark Clinical Trials - Right at Your Fingertips.
Latest Clinical Trials
BASIL-3 Trial: Evaluating Endovascular Strategies in Severe Leg Ischaemia
Staying up to date with landmark clinical trials is essential for evidence-based patient care, especially in fields like vascular surgery and interventional cardiology. The recently published BASIL-3 trial sheds light on the best endovascular approach for patients with chronic limb-threatening … Read More
Aortic Stenosis Severity Algorithm
Aortic Stenosis Severity Algorithm (ACC/AHA 2020 Guidelines) Step 1: Assess Aortic Valve Morphology and Function Step 2: Quantify AS Severity (Echocardiographic Parameters) Severity AVA (cm²) Mean Gradient (mmHg) Peak Velocity (m/s) Dimensionless Index (DI) Mild >1.5 <20 <3.0 >0.5 Moderate … Read More
IVUS-ACS Trial: Intravascular Ultrasound vs. Angiography for PCI in Acute Coronary Syndromes
IVUS-ACS Trial Summary Introduction In the management of acute coronary syndrome (ACS), optimal guidance for percutaneous coronary intervention (PCI) remains a critical factor in improving patient outcomes. The IVUS-ACS trial, a large, multicenter, randomized study, investigates whether intravascular ultrasound (IVUS)-guided … Read More
ADAPT-Sepsis Trial: PCT vs. CRP-Guided Antibiotic Duration
Understanding the ADAPT-Sepsis Trial: PCT vs. CRP-Guided Antibiotic Duration Sepsis remains a critical challenge in intensive care units (ICUs), often requiring prolonged antibiotic use. The ADAPT-Sepsis trial, published in JAMA (2024), aimed to determine whether procalcitonin (PCT)-guided or C-reactive protein … Read More
VT vs. SVT with Abberation Infographic
VT vs SVT with Aberration: A Quick Interpretation Guide Introduction Distinguishing ventricular tachycardia (VT) vs supraventricular tachycardia (SVT) with aberrancy is a critical skill in electrophysiology and emergency medicine. Misdiagnosis can lead to inappropriate treatment and adverse outcomes. This blog … Read More
CHANCE-3 Trial: Colchicine in Acute Stroke
Colchicine for Stroke Prevention (CHANCE-3 Trial) 📍 Study Type: Randomized, placebo-controlled trial🏥 Setting: 244 hospitals in China👥 Participants: 8,343 patients (age ≥40) with minor/moderate ischemic stroke or TIA & hs-CRP ≥2 mg/L Intervention vs. Control 💊 Colchicine Group (n=4,176)• 0.5 … Read More
SURMOUNT 3 Trial: Tirzepatide in Obesity
Visual Abstract Summary: SURMOUNT-3 Phase 3 Trial Objective: To evaluate the efficacy and safety of tirzepatide, a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, in achieving additional weight loss in adults with overweight or obesity who … Read More
HEAL-HOA Trial: volunteering among lonely older adults
Objective: To assess the effects of structured social volunteering over 12 months on loneliness among older adults during the COVID-19 pandemic. Study Design: Findings: 📉 Volunteering significantly reduced loneliness at 6 months (T2) compared to control: ⚠️ Most benefits were … Read More