Understanding the TRAIN Trial: Transfusion Strategies in Patients with Acute Brain Injury In 2024, a groundbreaking study called the TRAIN Trial explored the impact of different transfusion strategies in patients suffering from acute brain injuries. This large, pragmatic, phase 3 … Read More
ICU
TGC-Fast Trial: Tight Glucose Control in ICU
The TGC-Fast Trial, featured in the New England Journal of Medicine in 2023, was a multicenter, randomized, controlled trial that aimed to assess the benefits of tight glucose control without early parenteral nutrition in the intensive care unit (ICU). The … Read More
DEVICE Trial: Video versus Direct Laryngoscopy for Tracheal Intubation
DEVICE Trial Summary The article discusses the findings of the DEVICE trial, which aimed to determine whether video laryngoscopy increased the likelihood of successful tracheal intubation on the first attempt compared to direct laryngoscopy in critically ill adults. The trial … Read More
SAFE Trial Summary: Albumin or Saline in ICU
2004 SAFE TRIAL A comparison of albumin and saline for fluid resuscitation in the intensive care unit multicenter, double-blind, randomized controlled trial M Objective: To compare the effect of fluid resuscitation with albumin as compared with saline on mortality in … Read More
ADRENAL Trial Summary: Steroids in Septic Shock
ADJUNCTIVE GLUCOCORTICOID THERAPY IN PATIENTS WITH SEPTIC SHOCK – THE ADRENAL TRIAL Multicenter, double-blind, parallel-group, randomized, controlled trial 3,658 patients with septic shock requiring vasopressors and mechanical ventilation were randomized to VS Hydrocortisone Placebo (n=1,832) (n=1,826) Mean follow-up: 90 Days … Read More
ACURASYS Trial Summary: NM blockers in ARDS
2010 ACURASYS TRIAL Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome Multicenter, double-blinded, placebo-controlled trial Objective: To assess if administration of cisatracurium improve survival when compared to placebo in ICU patients undergoing mechanical ventilation for early severe ARDS 340 patients … Read More
3SITES Trial Summary: Central Venous Catheterization Insertion Site
2015 3SITES TRIAL Intravascular complications of central venous catheterization by insertion site Multicenter, randomized controlled trial Objective: To evaluate the risk of catheter related bloodstream infection or symptomatic catheter related deep-vein thrombosis in an adult patient who had been admitted … Read More
BOX Trial Summary: Oxygen Targets in Comatose Survivors of Cardiac Arrest
2022 BOX TRIAL: OXYGEN TARGETS IN OHCA Oxygen targets in comatose survivors of cardiac arrest Investigator-initiated, open-label, superiority,2×2 factorial design, randomized clinical trial Objective: To evaluate the appropriate oxygen target for mechanical ventilation in comatose survivors of out-of-hospital cardiac arrest … Read More
SPARK Trial Summary: Furosemide in critically ill patients with early AKI
2017 SPARK TRIAL The effect of low-dose furosemide in critically illl patients with early acute kidney injury (AKI) Pilot, multicenter, randomized, double-blinded, placebo-controlled trial Objective: To evaluate the impact of furosemide in early AKI on worsening AKI, kidney recovery and … Read More
PARTNER Trial Summary: Family-Support Intervention in ICU
2018 PARTNER TRIAL A Randomized trial of a Family-support intervention in intensive care units Multicenter, stepped-wedge, cluster-randomized trial Objective: To compare a multicomponent family-support intervention delivered by the interprofessional ICU team with usual care 1420 Inclusion criteria: Patients >18 years … Read More