Infectious Disease

STOP-IT Trial (2015): Short Course of Antibiotics for Intraabdominal Infections

stop it trial visual summary graphic abstract

2015, Short-Course Antimicrobial Therapy for Intraabdominal Infection, NEJM

STOP-IT Trial Key Points:

  1. A shorter course (3-5 days) of antibiotics was found to be non-inferior when compared to traditional course of 4 to 7 or 7 to 14 days.
  2. Important point was to adequately control the source which means draining the abscess in case there is one or any other nidus of infection.

Guidelines Related to STOP-IT trial

The 2009 IDSA guidelines suggested 4-7 days course of antibiotics once the source is adequately controlled. The STOP-IT trial tested more restrictive therapy of 3 to 5 days of antibiotics and found no difference in outcomes. The study addressed an important issue of antibiotic stewardship and cost containment especially in patients who came to hospital with intraabdominal infections.