Cardiovascular General Medicine

SPRINT MIND Trial (2019): Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia

SPRINT MIND Trial visual abstract

SPRINT-MIND Trial Summary: Authors of this trial randomized 9,361 adults aged 50 years or older with hypertension but without diabetes or history of stroke to either intensive control (SBP < 120 mmHg) or standard control (SBP < 140 mmHg). The objective was to assess if intensive blood pressure control reduces the occurrence of dementia as compared moderate control. The results showed no difference in terms of adjudicated probable dementia (P=0.10). However, it did show a significant decrease in mild cognitive impairment in patients whose BP was intensively controlled. (P=0.007) The authors of SPRINT-MIND trial concluded that in ambulatory adults with hypertension, intensive BP control (SBP < 120 mmHg) did not reduce the risk of probable dementia but significantly reduced mild cognitive impairment.

Source: JAMA