2022 TIME TRIAL Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK prospective, open-label, blinded-endpoint, randomized controlled trial IM Objective: To compare the major cardiovascular outcomes of evening dosing of antihypertensive medication … Read More
Cardiovascular Disease
Surgical Ablation of AFib with MV Surgery
2015 SURGICAL ABLATION OF ATRIAL FIBRILLATION TRIAL Surgical ablation of atrial fibrillation during mitral-valve surgery parallel, randomized controlled trial M Objective: To evaluate treatment with mitral valve surgery plus ablation compared with mitral valve surgery alone among patients with mitral … Read More
SUPPORT Trial Summary: Olmesartan in CHF
2015 SUPPORT TRIAL M Clinical impacts of additive use of olmesartan in hypertensive patients with chronic heart failure (CHF) prospective, open-label, randomized controlled trial Objective: to examine whether an additive treatment with an ARB, olmesartan, reduces the mortality and morbidity … Read More
SIMPLE Trial Summary: ICD Implantation without VFib Induction
2015 SIMPLE TRIAL Cardioverter defibrillator implantation without induction of ventricular fibrillation multicentre, single-blind, non-inferiority, randomized controlled trial M Objective: To compare the efficacy & safety of ICD implantation without defibrillation testing versus the standard of ICD implantation with defibrillation testing … Read More
SERVE HF Trial Summary: Adaptive sero-ventilation for CSA in HF
2015 SERVE-HF TRIAL M Adaptive servo-ventilation for central sleep apnea in systolic heart failure parallel, randomized controlled trial Objective: To assess the effectiveness of adaptive servo-ventilation Damong subjects with heart failure with reduced ejection fraction and central sleep apnea 1315 … Read More
SECURE PCI Trial Summary: Loading Atorvastatin in ACS
2018 SECURE-PCI TRIAL Effect of loading dose of atorvastatin prior to planned percutaneous coronary intervention on major adverse cardiovascular events in acute coronary syndrome double-blind, multicenter, randomized controlled trial Objective: To determine if periprocedural loading doses of atorvastatin decrease 30-day … Read More
SCOPE I Trial Summary: Self-expanding vs Balloon Expandable Valve in TAVR
2019 SCOPE I TRIAL Safety and efficacy of a self-expanding versus a balloon-expandable bioprosthesis for transcatheter aortic valve replacement (TAVR) in patients with symptomatic severe aortic stenosis noninferiority, randomized controlled trial M Objective: To compare the safety and efficacy of … Read More
AMACING Trial Summary: IV Hydration for CIN
2017 AMACING TRIAL Prophylactic hydration to protect renal function from intravascular iodinated contrast material in patients at high risk of contrast-induced nephropathy. M Single-center, randomised, parallel-group, open-label, phase 3, non-inferiority trial 660 patients Objective: To evaluate the impact of prophylactic … Read More
ALLHAT-LLT Trial Summary: Pravastatin in Moderate HLD
2002 ALLHAT-LLT Pravastatin vs Usual Care in Moderately Hypercholesterolemic, Hypertensive Patients Multicenter, randomized, nonblinded trial M Objective: To determine whether pravastatin compared with usual care reduces all-cause mortality in older, moderately hypercholes- terolemic, hypertensive participants with at least 1 additional … Read More
ALIVE Trial Summary: Amiodarone or Lidocaine in VFib
2002 ALIVE TRIAL Amiodarone as Compared with Lidocaine for Shock-Resistant Ventricular Fibrillation Prospective, randomized, controlled, double-dummy trial Objective: To determine whether amiodarone compared with lidocaine could improve survival rates to hospital admission in patients with shock-refractory, out-of-hospital cardiac arrest. 344 … Read More