Cardiovascular Disease

CATCH Trial Summary: Tinzaparin for VTE in Cancer

2015 CATCH TRIAL Tinzaparin vs warfarin for treatment of acute venous thromboembolism in patients with active cancer phase 3, multinational, open-label, randomized controlled trial Objective: To assess the efficacy and safety of tinzaparin vs warfarin for treatment of acute, symptomatic … Read More

COACH Trial Summary: Access to Care in Heart Failure

2022 COACH TRIAL Trial of an intervention to improve acute heart failure outcomes cross-sectional, cluster-randomized trial M Objective: To determine the effectiveness of systematic use of a hospital-based point-of-care tool to support clinical decision-making, followed by rapid follow-up in an … Read More

DCP Trial Summary: HCTZ vs Chlorthalidone

2022 DCP TRIAL Chlorthalidone compared with hydrochlorothiazide for the preven- tion of cardiovascular events in patients with hypertension: The Diuretic Comparison Project (DCP) Open-label, pragmatic, randomized controlled trial Objective: To compare the differences between hydrochlorothiazide (HCTZ) compared with chlorthalidone in … Read More

UNIVERSAL Trial Summary: US-Guided Femoral Access

2022 UNIVERSAL TRIAL Routine ultrasonography guidance for femoral vascular access for cardiac procedures multicenter, randomized controlled trial Objective: To determine whether routinely using ultrasonography guidance for femoral arterial access for coronary angiography/intervention reduces bleeding or vascular complications 621 Patients Inclusion … Read More

TIME Trial Summary: Morning vs. Evening dose of Antihypertensives

2022 TIME TRIAL Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK prospective, open-label, blinded-endpoint, randomized controlled trial IM Objective: To compare the major cardiovascular outcomes of evening dosing of antihypertensive medication … Read More

Surgical Ablation of AFib with MV Surgery

2015 SURGICAL ABLATION OF ATRIAL FIBRILLATION TRIAL Surgical ablation of atrial fibrillation during mitral-valve surgery parallel, randomized controlled trial M Objective: To evaluate treatment with mitral valve surgery plus ablation compared with mitral valve surgery alone among patients with mitral … Read More

SUPPORT Trial Summary: Olmesartan in CHF

2015 SUPPORT TRIAL M Clinical impacts of additive use of olmesartan in hypertensive patients with chronic heart failure (CHF) prospective, open-label, randomized controlled trial Objective: to examine whether an additive treatment with an ARB, olmesartan, reduces the mortality and morbidity … Read More

SIMPLE Trial Summary: ICD Implantation without VFib Induction

2015 SIMPLE TRIAL Cardioverter defibrillator implantation without induction of ventricular fibrillation multicentre, single-blind, non-inferiority, randomized controlled trial M Objective: To compare the efficacy & safety of ICD implantation without defibrillation testing versus the standard of ICD implantation with defibrillation testing … Read More

SERVE HF Trial Summary: Adaptive sero-ventilation for CSA in HF

2015 SERVE-HF TRIAL M Adaptive servo-ventilation for central sleep apnea in systolic heart failure parallel, randomized controlled trial Objective: To assess the effectiveness of adaptive servo-ventilation Damong subjects with heart failure with reduced ejection fraction and central sleep apnea 1315 … Read More

SECURE PCI Trial Summary: Loading Atorvastatin in ACS

2018 SECURE-PCI TRIAL Effect of loading dose of atorvastatin prior to planned percutaneous coronary intervention on major adverse cardiovascular events in acute coronary syndrome double-blind, multicenter, randomized controlled trial Objective: To determine if periprocedural loading doses of atorvastatin decrease 30-day … Read More