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Clinical trials summarized as Visual Abstracts

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Category: Cardiovascular Disease

Posted onSeptember 27, 2020October 22, 2020Cardiovascular Disease

VERTIS CV Trial: Ertugliflozin Effect on CV Outcomes in Type 2 Diabetes

by admin

VERTIS CV Trial: The SGLT-2 inhibitors are the next generation drugs for type 2 diabetes as well as patients with heart failure. We have seen…

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Posted onSeptember 11, 2020November 9, 2020Cardiovascular Disease

EMPEROR Reduced Trial: Empagliflozin in HFrEF

by admin

The SGLT-2 inhibitors were initially developed for diabetes but eventually noted to have significant effects on outcomes in patients with heart failure in addition to…

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Posted onSeptember 4, 2020October 22, 2020Cardiovascular Disease

REALITY Trial: Transfusion in Patients With Myocardial Infarction and Anemia

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Multiple small trials in the past have shown benefits of liberal transfusion strategy in patients having active MI. However, a large size trial was lacking.…

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Posted onSeptember 2, 2020November 13, 2020Cardiovascular Disease

EAST AFNET 4 Trial: Early Rhythm control in Atrial Fibrillation

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In patients with nonvalvular afib, rate control was considered to be no different than rhythm control based on the AFFIRM trial results that was published…

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Posted onSeptember 1, 2020October 23, 2020Cardiovascular Disease

EXPLORER-HCM Trial: Mavacamten for Symptomatic Obstructive Hypertrophic Cardiomyopathy

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EXPLORER HCM Trial Summary: Mavacamten is a novel cardiac-specific myosin ATPase inhibitor. It specifically reduces excessive cross-bridging with actin, which is associated with pathological hypercontractility…

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Posted onMay 3, 2020July 24, 2020Cardiovascular Disease

PADIT Trial: Prevention of Arrhythmia Device Infection Trial

by admin1 Comment on PADIT Trial: Prevention of Arrhythmia Device Infection Trial

PADIT Trial Summary The PADIT Trial (Prevention of Arrhythmia Device Infection Trial) was a cluster randomized crossover trial that was designed to assess the efficacy…

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Posted onMay 2, 2020July 24, 2020Cardiovascular Disease

WRAP-IT Trial: Antibacterial Envelope to Prevent Device Infections

by admin1 Comment on WRAP-IT Trial: Antibacterial Envelope to Prevent Device Infections

WRAP-IT trial summary WRAP-IT trial is a multicenter, randomized, controlled, prospective, single-blind trial that was published in the New England Journal of medicine in 2019.…

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Posted onMay 2, 2020July 24, 2020Cardiovascular Disease

WOSCOPS Trial: Prevention of CAD with Pravastatin

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WOSCOPS Trial Summary WOSCOPS trial was a double-blind, parallel-group, randomized, placebo-controlled trial that was designed to assess the benefit of pravastatin in reducing CV events…

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Posted onMay 2, 2020July 24, 2020Cardiovascular Disease

WOEST Trial: clopidogrel ± aspirin in patients taking PO anticoagulants and undergoing PCI

by admin

WOEST Trial Summary: The WOEST trial was a multicenter, open-label, randomized, controlled clinical trial to assess if clopidogrel alone could reduce bleeding risk compared to…

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Posted onMay 2, 2020July 24, 2020Cardiovascular Disease

WARFASA Trial: Aspirin for preventing the recurrence of VTE

by admin

WARFASA Trial Summary The WARFASA trial was a multicenter, double-blinded, randomized, placebo-controlled trial to assess whether aspirin could reduce the recurrence of venous thromboembolism (VTE)…

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