Year: 2019 Title: CAROLINA TRIAL Subtitle: Effect of Linagliptin vs Glimepiride on Major Adverse Cardiovascular Outcomes in Patients With Type 2 Diabetes Type of Trial: An International, Randomised, Parallel Group, Double Blind Trial Objective: To assess cardiovascular outcomes of linagliptin … Read More
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AiDAPT Trial: Automated Insulin Delivery in Pregnancy Complicated by T1DM
Year: 2023 Title: AiDAPT TRIAL Subtitle: Automated Insulin Delivery in Women with Pregnancy Complicated by Type 1 Diabetes Type of Trial: Interventional, randomized controlled trial Objective: To find definitive proof of a benefit to women by using automated closed-loop for … Read More
FULL REVASC Trial: FFR-Guided Complete PCI in MI
Year: 2024 Title: FULL REVASC Subtitle: FFR-Guided Complete or Culprit-Only PCI in Patients with Myocardial Infarction Type of Trial: A registry-based, randomized, parallel, blinded trial Objective: To evaluate the benefit of fractional flow reserve (FFR)–guided complete revascularization compared with usual … Read More
SMART Trial: TAVR in Small Aortic Annulus
Year: 2024 Title: SMART TRIAL Subtitle: Self-Expanding or Balloon-Expandable TAVR in Patients with a Small Aortic Annulus Type of Trial: A prospective, randomized controlled, post-market trial Objective: To generate clinical evidence on valve safety and performance of self-expanding (SE) versus … Read More
Beta Blockers After MI and Preserved EF
Year: 2024 Title: REDUCE-AMI Subtitle: Beta-Blockers after Myocardial Infarction and Preserved Ejection Fraction Type of Trial: A randomized, parallel-group, open-label trial Objective: To determine whether long-term treatment with oral beta-blockade in patients with myocardial infarction and preserved left ventricular systolic … Read More
EMPACT-MI: Empagliflozin after MI
Year: 2024 Title: EMPACT-MI Subtitle: Empagliflozin after Acute Myocardial Infarction Type of Trial: A double-blind, randomized, placebo-controlled trial Objective: To assess if the use of empagliflozin in the treatment of acute myocardial infarction (AMI) affects future mortality or heart failure … Read More
STEP-HFpEF DM: Semaglutide in HFpEF and DM
The study suggests that Semaglutide is effective in reducing symptoms and weight in patients with obesity-related heart failure with preserved ejection fraction and type 2 diabetes when compared to a placebo
ACORN Trial: Cefepime vs. Piperacillin-Tazobactam
The ACORN Trial: Cefepime vs. Piperacillin-Tazobactam’s Impact on Renal Outcomes In 2023, the ACORN Trial set out to investigate the renal and neurological outcomes of hospitalized adults with acute infections treated with two common antibiotics, providing valuable insights for healthcare … Read More
RESCUE-ASDH: Craniotomy vs. Decompressive Craniectomy
The RESCUE-ASDH Trial: Craniotomy vs. Decompressive Craniectomy The RESCUE-ASDH Trial, conducted in 2023, was a multicenter, randomized, controlled trial that played a crucial role in understanding the management of acute subdural hematoma (ASDH), a severe brain injury. Objective of the … Read More
PACER Trial: Platelet Transfusion before CVC Placement
The PACER Trial: Revisiting Platelet Transfusions for CVC Placement The 2023 PACER Trial investigated a critical aspect of clinical care involving patients with thrombocytopenia undergoing central venous catheter (CVC) placement. This parallel, single-blinded, randomized controlled trial aimed to establish whether … Read More