ADJUNCTIVE GLUCOCORTICOID THERAPY IN PATIENTS WITH SEPTIC SHOCK – THE ADRENAL TRIAL Multicenter, double-blind, parallel-group, randomized, controlled trial 3,658 patients with septic shock requiring vasopressors and mechanical ventilation were randomized to VS Hydrocortisone Placebo (n=1,832) (n=1,826) Mean follow-up: 90 Days PRIMARY OUTCOMES 27.9% Death from Any Cause at 90 Days 28.8% 3 P=0.50 © SECONDARY OUTCOMES Median time to shock reversal, days P<0.001 4 In patients with septic shock on mechanical ventilation and receiving vasopressors, a week of hydrocortisone 200 mg/day did not reduce 90 day mortality but may be associated with shorter time to reversal of shock, time to extubation and length of ICU stay N Engl J Med 2018; 378:797-808 | Venkatesh B et al.