Visual Summaries of Landmark Clinical Trials
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Cardiology
Acute Coronary Syndrome
ATLAS ACS-2: Rivaroxaban after ACS
CAPRICORN Trial: Effect of carvedilol on outcome after MI in patients with LV dysfunction
CAST I: Use of Antiarrhythmics post-MI for Cardiac Arrhythmia Suppression
CHAMPION PHOENIX: Cangrelor in PCI
COMFORTABLE-AMI (2014) – Biolimus-eluting stents with biodegradable polymer versus bare-metal stents in acute MI
COMMIT Trial: Metoprolol in Acute Myocardial Infarction
CULPRIT-SHOCK: Culprit lesion vs multivessel PCI in ACS with cardiogenic shock
CURE: Effects of Clopidogrel plus Aspirin in Patients with NSTEMI
EPHESUS: Eplerenone in patients with LV dysfunction after MI
IMPROVE IT (2015): Ezetimibe + statin in acute coronary syndrome (ACS)
ESSENCE: Enoxaparin vs Unfractionated Heparin for UA/NSTEMI
FRISC II Trial (2006): Invasive vs non-invasive treatment in unstable CAD
IABP-SHOCK II Trial (2012): Intraaortic Balloon Support for Myocardial Infarction with Cardiogenic Shock
IMPROVE IT (2015): Ezetimibe + statin in acute coronary syndrome (ACS)
ISAR-REACT 5 Trial (2019) – Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes
MADIT-II (2002): Prophylactic ICD in Patients with Myocardial Infarction and Reduced Ejection Fraction
MIRACL Trial (2001): Atorvastatin use for early recurrent ischemic events in ACS
OASIS-5 Trial (2006) -Comparison of Fondaparinux and Enoxaparin in Acute Coronary Syndromes
OAT Trial (2006) – Coronary Intervention for Persistent Occlusion after Myocardial Infarction
ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes with Alirocumab after an ACS
PROVE IT Trial (2004): Intensive vs Moderate Lipid Lowering with Statins after ACS
RAPID-TnT Trial (2009) – 1-Hour Troponin T Protocol in Suspected Acute Coronary Syndromes
SADHART Trial: Sertraline Use in Depression after ACS
SCOT-HEART Trial: Coronary CT Angiography and Risk of Myocardial Infarction
SMART-DATE Trial (2018): 6 vs 12 months of DAPT after PCI with DES in ACS
TIMACS Trial (2009): Early versus Delayed Invasive Intervention in ACS
TREAT Trial (2019)
TROPICAL-ACS Trial (2017)
ULTIMATE Trial: IVUS vs Angiography-Guided Implantation of DES
VALIANT Trial (2003): Valsartan, Captopril, or Both in Myocardial Infarction
VEST Trial: Vest Prevention of Early Death Trial
Amyloidosis
ATTR-ACT Trial (2018): Tafamidis treatment for patients with transthyretin amyloid cardiomyopathy.
Atrial Fibrillation
AATAC Trial (2016): Ablation vs. amiodarone for treatment of persistent atrial fibrillation in patients with congestive heart failure and an implanted device
ALCOHOL-AF Trial: Impact of Alcohol Abstinence in Moderate Drinkers With Atrial Fibrillation
AF-CHF Trial (2008): Rhythm Control versus Rate Control for Atrial Fibrillation and Heart Failure
AFFIRM Trial: Rate control vs Rhythm control in Atrial Fibrillation
ARISTOTLE: Apixaban vs. warfarin in atrial fibrillation
AUGUSTUS Trial (2019): Antithrombotic therapy or PCI in Atrial Fibrillation
BRIDGE Trial (2015): Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation
CABANA Trial: Catheter Ablation vs Anti-arrhythmic Drug Therapy for Atrial Fibrillation
CASTLE-AF: Catheter Ablation for Atrial Fibrillation with Heart Failure
CRYSTAL-AF: Cryptogenic Stroke and Underlying Atrial Fibrillation
EMBRACE Trial (2014): Atrial fibrillation in patients with cryptogenic stroke
PROTECT AF Trial: Closure of the LAA versus warfarin therapy in patients with Atrial Fibrillation
FIRE AND ICE Trial (2016): Cryoballoon or RF ablation for paroxysmal atrial fibrillation
RE-DUAL PCI Trial (2017): Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation
ROCKET-AF: Rivaroxaban vs. warfarin in atrial fibrillation
RACE II: Strict vs Lenient Control of Heart Rate in Atrial Fibrillation
CABG
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FIRE AND ICE Trial (2016): Cryoballoon or RF ablation for paroxysmal atrial fibrillation
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