Visual Summaries of Randomized Controlled Trials
The HEALTH trial was a prospective surgical randomized trial that aimed to assess the efficacy of total hip arthroplasty as compared with hemiarthroplasty in patients who had a displaced femoral neck fracture. Total hip arthroplasty…
The RECORD trial was a prospective, randomized, open-label trial that assessed if addition of rosiglitazone to either metformin or sulfonylurea increase the rate of adverse CV outcomes as compared to the combination of metformin and…
The objective of FIRE AND ICE trial is to compare balloon cryoablation with traditional radiofrequency ablation (RFA) in terms of long-term atrial fibrillation-free survival in patients with symptomatic paroxysmal atrial fibrillation (PAF). Patients with symptomatic…
Cryptogenic stroke has long been associated with PFO and underlying undetected atrial fibrillation. The EMBRACE trial was an important step forward. It hypothesized that many of the patients with cryptogenic stroke had underlying AF that…
Following the CV safety concerns with rosiglitazone especially new incidence of heart failure, the FDA mandated that all new diabetes drugs conduct studies demonstrating CV safety. SAVOR-TIMI trial sought to study the cardiovascular (CV) safety…
The TECOS trial is a multicenter, randomized, double-blind study that sought to study the cardiovascular (CV) safety of sitagliptin in patients with type 2 diabetes mellitus (DM2). It enrolled 14,671 patients with DM2 and established…
The EASE trial was a prospective randomized clinical trial that aimed to assess if early surgery reduces mortality and embolic events as compared to conventional treatment among patients with left-sided native-valve endocarditis (NVE) at high…
The AF-CHF trial is a multicenter, prospective, randomized, controlled trial that assessed if rhythm-control reduces CV mortality in patients with AF and HFrEF as compared to rate control. 1,376 patients with nonvalvular atrial fibrillation and…