Tocilizumab is an antiinflammatory monoclonal antibody that was initially developed for rheumatoid arthritis. Based on its antiinflammatory mecahnism of action, it was hypothesized to have…
VERTIS CV Trial: The SGLT-2 inhibitors are the next generation drugs for type 2 diabetes as well as patients with heart failure. We have seen…
The SGLT-2 inhibitors were initially developed for diabetes but eventually noted to have significant effects on outcomes in patients with heart failure in addition to…
Multiple small trials in the past have shown benefits of liberal transfusion strategy in patients having active MI. However, a large size trial was lacking.…
In patients with nonvalvular afib, rate control was considered to be no different than rhythm control based on the AFFIRM trial results that was published…
EXPLORER HCM Trial Summary: Mavacamten is a novel cardiac-specific myosin ATPase inhibitor. It specifically reduces excessive cross-bridging with actin, which is associated with pathological hypercontractility…
The ICTOC trial was a small scale, single center unblinded trial that showed the benefits of compression stockings in order to prevent recurrence of cellulitis…
BREATHE-1 Trial (Bosentan in PAH) Summary Published in 2002, the BREATHE-1 trial investigated the effect of bosentan on exercise capacity in a larger number of…
PADIT Trial Summary The PADIT Trial (Prevention of Arrhythmia Device Infection Trial) was a cluster randomized crossover trial that was designed to assess the efficacy…
WRAP-IT trial summary WRAP-IT trial is a multicenter, randomized, controlled, prospective, single-blind trial that was published in the New England Journal of medicine in 2019.…